Background. This prospective, randomized, controlled trial compared the progression of vascular and cardiac valve calcification in 360 prevalent adult hemodialysis patients with secondary hyperparathyroidism treated either cinacalcet plus low-dose vitamin D sterols or flexible doses alone. Methods. Eligible subjects were on for ≥ 3 months parathyroid hormone (PTH) > 300 pg/mL PTH 150–300 calcium–phosphorus product 50 mg2/dL2 while receiving D. All received calcium-based phosphate binders....

C.E.R.A., a continuous erythropoietin receptor activator, is in development to provide anemia correction and stable maintenance of hemoglobin (Hb) levels at extended administration intervals patients with chronic kidney disease (CKD). This study examined its efficacy safety when administered up once monthly who have CKD are on dialysis randomly convert directly from epoetin alpha or beta one three times weekly.In this three-arm, comparator-controlled, open-label, randomized, parallel-group,...

Roxadustat is an orally administered hypoxia-inducible factor prolyl hydroxylase inhibitor being developed for the treatment of anemia chronic kidney disease (CKD). This European, phase 3, randomized, open-label, active-controlled study investigated efficacy and safety roxadustat in patients with end-stage on dialysis at least 4 months. Patients were randomized to switch from erythropoiesis-stimulating agent (ESA) (epoetin alfa or darbepoetin alfa) three times/week continue their previous...

This integrated phase 3 analysis examined efficacy and cardiovascular safety for roxadustat vs erythropoiesis-stimulating agents (ESAs) in dialysis-dependent patients.

Background. The ADVANCE (A Randomized Study to Evaluate the Effects of Cinacalcet plus Low-Dose Vitamin D on Vascular Calcification in Subjects with Chronic Kidney Disease Receiving Haemodialysis) objective is assess effect cinacalcet low-dose active vitamin versus flexible dosing progression coronary artery calcification (CAC) haemodialysis patients. We report design and baseline subject characteristics.

BACKGROUND: Hypertension is a recognized marker of poor prognosis in IgA nephropathy. METHODS: The present study investigated the prevalence white-coat hypertension, diurnal rhythm blood pressure (BP), effectiveness antihypertensive drug therapy, and effect above on progression kidney disease One hundred twenty-six nephropathy patients were selected consecutively for 24-h ambulatory monitoring (ABPM). Fifty-five normotensive 71 treated hypertensives. Their drugs angiotensin-converting enzyme...

This cross-sectional study was designed to assess the relationship between vascular stiffness (VS) and bone-related proteins involved in development of arteriosclerosis patients on regular hemodialysis (HD).68 consecutive stable clinical condition who received HD FMC Dialysis Center, Pécs were included. VS parameters (carotid-femoral pulse wave velocity - PWV, aortic augmentation index AIx) determined by applanation tonometry (SphygmoCor, AtCor Medical, Sidney) routine latoratory test...

Cardiovascular (CV) diseases are the most common causes of morbidity and mortality in hemodialysis (HD) patients. We studied effect high visit-to-visit ultrafiltration (UF) variability on CV abnormalities HD

In this observational study we addressed accelerated arteriosclerosis (AS) in patients with chronic renal failure (CRF) on hemodialysis (HD) by measuring vascular stiffness (VS) parameters and attempted to relate them pro-inflammatory protective factors.96 consecutive receiving regular HD were included. 20 adult without major renal, cardiovascular or metabolic morbidities served as controls.AS (carotid-femoral pulse wave velocity - PWV, aortic augmentation index Aix) measured using...

Abstract Introduction In chronic kidney disease (CKD), like in IgA nephropathy (IgAN), cardiovascular (CV) mortality and morbidity are many times higher than the general population, left ventricular hypertrophy (LVH) is an independent risk factor for CV disease. This follow-up study investigated association between mass index (LVMI) renal or outcomes. Methods We examined 118 IgAN patients prospectively. LVMI LV geometry was using echocardiography. The primary combined endpoints were total...

In chronic kidney disease, IgA nephropathy, and left ventricular diastolic dysfunction have prognostic significance as well. However, the relationship between dysfunction, arterial stiffness, renal function has not been fully elucidated.79 nephropathy patients (aged 46 ± 11 years) 50 controls were investigated. Tissue Doppler imaging was used to measure early (Ea) late (Aa) velocities. Arterial stiffness measured by a photoplethysmographic (stiffness index (SI)) an oscillometric method...

Achieving target levels of laboratory parameters bone and mineral metabolism in chronic kidney disease (CKD) patients is important but also difficult those living with end-stage disease. This study aimed to determine if there are age-related differences disease-mineral disorder (CKD-MBD) characteristics, including treatment practice Hungarian dialysis patients. Data were collected retrospectively from a large cohort Hungary. Patients on hemodialysis peritoneal included. The enrolled...

Central line-associated bloodstream infections (CLABSIs) often result from intraluminal microbial colonization and are associated with morbidity, mortality, substantial costs. The use of antimicrobial catheter lock solutions may reduce the incidence CLABSI.Patients undergoing hemodialysis (HD) through a prevalent central venous (CVC) were randomly assigned to have their CVC locked between dialysis sessions an solution that contained trimethoprim 5 mg/mL, ethanol 25%, Ca-EDTA 3%...

IgA nephropathy (IgAN) is the most common primary glomerular disease. Endothelin-1 (ET-1) one of strongest vasoconstrictor materials in blood. The N-terminal prohormone brain natriuretic peptide (NT-proBNP) associated with renal function and poor outcomes chronic kidney disease (CKD). Serum endocan a biomarker proinflammatory cytokines, increase serum level plays critical role inflammatory, proliferative, neovascularization processes cardiovascular patients CKD too. Identifying high-risk...

ObjectivesPatients with end-stage renal failure (ESRF) treated erythropoiesis-stimulating agents (ESAs) are often ESA-hyporesponsive associated free radical production. Hydroxyl converts phenylalanine into ortho-tyrosine, while physiological isomer para-tyrosine is formed enzymatically, mainly in the kidney. Production of 'para-tyrosine' decreased ESRF and it can be replaced by ortho-tyrosine proteins. Our aim was to study role tyrosines ESA-responsiveness.MethodsFour groups volunteers were...

Here we report the serum carnitine ester profile during and after 1g iv/day L-carnitine supplementation in haemodialysis patients.Seven patients were studied over 29 weeks. After a control day, 12 weeks of replacement therapy was introduced followed by 17 washout period. The acylcarnitine concentrations determined isotope dilution ESI MS/MS technique.At baseline significantly decreased free (48%, p < 0.01) 1.5-16-fold elevation 16 out 27 acylcarnitines detected HD compared with controls. On...

Background and aims Autosomal-dominant polycystic kidney disease (ADPKD) is one of the most common causes end-stage renal (ESRD). The important cause death among ADPKD patients cardiovascular (CV). aim this study was to examine prognostic significance arterial stiffness on CV outcomes in ADPKD. Methods A total 55 with were examined. Pulse wave velocity determined index (SIDVP) calculated. Combined primary endpoints (CV renal) major events (myocardial infarction, stroke, intervention) as...

&lt;b&gt;&lt;i&gt;Introduction:&lt;/i&gt;&lt;/b&gt; Data on the role of irisin in vascular calcification patients with end-stage renal diseases regular dialysis are inconsistent, and underlying mechanisms not clearly defined. The present study was designed to explore association serum stiffness impact well-established risk factors. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; clinical enrolled 52 hemodialysis (HD) 15 continuous ambulatory peritoneal (PD) an age &amp;#x3e;18 years receiving...

&lt;i&gt;Aims:&lt;/i&gt; To define the role of asymmetric dimethylarginine (ADMA) in control blood pressure (BP) during hemodialysis (HD). &lt;i&gt;Methods:&lt;/i&gt;&lt;i&gt;L&lt;/i&gt;-Arginine, ADMA and symmetric (SDMA) levels patients with (n = 18) or without 13) hypotensive episodes HD sessions were measured before after treatment by liquid chromatography-mass spectrometry. Clinical variables, laboratory parameters underlying pathologies end-stage renal disease (ESRD) comparable groups....

&lt;i&gt;Background/Aims:&lt;/i&gt; In hemodialyzed (HD) patients, adiponectin and sE-selectin levels are elevated, while antioxidant paraoxonase 1 activity (PON1) is decreased. We determined if the hyperadiponectinemia in HD patients has a protective effect on decrease PON1 elevation kidney failure. &lt;i&gt;Methods Design:&lt;/i&gt; Predialysis serum adiponectin, as well other metabolic variables were measured 70 patients. &lt;i&gt;Results:&lt;/i&gt; Adiponectin had (1) no association with...