A5101769439- Atherosclerosis and Cardiovascular Diseases
- Nitric Oxide and Endothelin Effects
- Acute Kidney Injury Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Renin-Angiotensin System Studies
- Glycosylation and Glycoproteins Research
- Cardiac Ischemia and Reperfusion
- Hormonal Regulation and Hypertension
- Estrogen and related hormone effects
- Elbow and Forearm Trauma Treatment
- Galectins and Cancer Biology
- Chronic Kidney Disease and Diabetes
- Lysosomal Storage Disorders Research
- Protease and Inhibitor Mechanisms
- Orthopedic Surgery and Rehabilitation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immune Response and Inflammation
- Musculoskeletal Disorders and Rehabilitation
- Adipokines, Inflammation, and Metabolic Diseases
- Carbohydrate Chemistry and Synthesis
- Renal and related cancers
- NF-κB Signaling Pathways
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Nicotinic Acetylcholine Receptors Study
- Shoulder Injury and Treatment
University of Alabama at Birmingham
2013-2024
Inner Mongolia Medical University
2024
RELX Group (United States)
2020
Pediatric Nephrology of Alabama
2012-2019
University of Alabama
2007-2019
Birmingham VA Medical Center
2012-2018
Peking University
2018
Memorial Sloan Kettering Cancer Center
2015
Tulane University
2015
Indian Institute of Chemical Biology
2006
Background— We have previously shown that estrogen (17β-estradiol; E2) inhibits neointima formation and migration of leukocytes, particularly neutrophils, into rat carotid arteries after acute endoluminal injury. This study tested the hypothesis E2 expression adhesion molecules, chemokines, proinflammatory cytokines in early hours balloon injury, thus attenuating stimulus for leukocyte entry negatively modulating injury response. Methods Results— Ovariectomized (OVX) rats were randomly...
Background NFκB signaling is critical for expression of genes involved in the vascular injury response. We have shown that estrogen (17β-estradiol, E2) inhibits these an receptor (ER)-dependent manner injured rat carotid arteries and tumor necrosis factor (TNF)-α treated aortic smooth muscle cells (RASMCs). This study tested whether E2 RASMCs defined mechanisms. Methodology/Principal Findings TNF-α demonstrated rapid degradation IκBα (10–30 min), followed by dramatic increases mRNA protein...
Despite the prevalence and recognition of its detrimental impact, clinical complications sepsis remain a major challenge. Here, we investigated effects myeloid ferritin heavy chain (FtH) in regulating pathogenic sequelae sepsis. We demonstrate that deletion FtH leads to protection against lipopolysaccharide-induced endotoxemia cecal ligation puncture (CLP)-induced model as evidenced by reduced cytokine levels, multi-organ dysfunction mortality. identified such is predominantly mediated...
We have previously shown that 17beta-estradiol (E2) attenuates responses to endoluminal injury of the rat carotid artery, at least in part, by decreasing inflammatory mediator expression and neutrophil infiltration into injured vessel, with a major effect on neutrophil-specific chemokine cytokine-induced chemoattractant (CINC)-2 beta. Current studies tested hypothesis activated aortic smooth muscle cells (RASMCs) express these same mediators induce migration vitro E2 inhibits processes an...
Background We have shown that glucosamine (GlcN) or O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate (PUGNAc) treatment augments O-linked-N-acetylglucosamine (O-GlcNAc) protein modification and attenuates inflammatory mediator expression, leukocyte infiltration neointima formation in balloon injured rat carotid arteries identified the arterial smooth muscle cell (SMC) as target injury response. NFκB signaling has been to mediate expression of genes arteries....
Inflammation plays a major role in vascular disease. We have shown that leukocyte infiltration and inflammatory mediator expression contribute to remodeling after endoluminal injury. This study tested whether increasing protein O-linked-N-acetylglucosamine (O-GlcNAc) levels with glucosamine (GlcN) O-(2-acetamido-2-deoxy-d-glucopyranosylidene) amino-N-phenylcarbamate (PUGNAc) inhibits acute neointimal responses arterial Ovariectomized rats were treated single injection of GlcN (0.3 mg/g ip),...
Because of the less-than-robust response to therapy and impact on choice optimal chemotherapy prognosis, chronic kidney disease has drawn attention in treatment multiple myeloma, a malignant hematologic disorder that can produce significant amounts monoclonal immunoglobulin free light chains (FLCs). These low-molecular-weight proteins are relatively freely filtered through glomerulus reabsorbed by proximal tubule. The present study demonstrated during process metabolism FLCs, ROS activated...
This study tested the hypothesis that expression of novel adhesion molecule periostin (PN) and osteopontin (OPN) is increased in lung isolated pulmonary arterial smooth muscle cells (PASMCs) response to stress hypoxia explored signaling pathways involved. Adult male rats were exposed 10% O2 for 2 wk, growth-arrested rat PASMCs incubated under 1% 24 h. Hypoxia PN OPN mRNA lung. In PASMCs, but not expression. The hypoxia-responsive growth factors fibroblast factor-1 (FGF-1) angiotensin II (ANG...
Epidemiological studies have established the role of cigarette smoking as a risk factor in progression chronic kidney disease, including diabetic nephropathy. We previously reported that nicotine promotes mesangial cell proliferation and hypertrophy via activation nonneuronal nicotinic acetylcholine receptors worsens renal injury model acute glomerulonephritis (Jaimes E, Tian RX, Raij L. Am J Physiol Heart Circ 292: H76–H82, 2007; Jaimes EA, Joshi M, Nephrol 29: 319–326, 2009). These were...
Clinical studies have established the role of cigarette smoking as a risk factor in progression chronic kidney disease (CKD). We shown that nicotine promotes mesangial cell proliferation and hypertrophy via nonneuronal nicotinic acetylcholine receptors (nAChRs). The α7-nAChR is one most important subunits nAChRs. These were designed to test hypothesis worsens renal injury rats with 5/6 nephrectomy (5/6Nx) subunit required for these effects. studied five different groups: Sham, 5/6Nx, 5/6Nx +...
Inflammation plays a central role in the pathogenesis of many forms vascular disease, including atherosclerosis. Atherogenesis begins with endothelial damage, and damaged endothelium expresses adhesion molecules, chemokines, proinflammatory cytokines that direct atherosclerotic plaque formation spill into circulation as biomarkers disease risk. Menopausal hormone therapy, variety estrogen preparations or without progestin, has negative modulatory effects on most these soluble inflammatory...
17beta-estradiol (E2) negatively modulates neointima formation, leukocyte infiltration, and proinflammatory mediator expression after vascular injury in young (10-wk-old) ovariectomized (OVX) rats. Trials of E2 elderly postmenopausal women have not confirmed a vasoprotective effect. This study tested the hypothesis that responsiveness to is lost injured arteries aged (12-mo-old) OVX rats.E2- or vehicle-treated rats underwent balloon carotid artery were killed 2 weeks for morphometric...
Lewisite (2-chlorovinyldichloroarsine) is an organic arsenical chemical warfare agent that was developed and weaponized during World Wars I/II. Stockpiles of lewisite still exist in many parts the world pose potential environmental human health threat. Exposure to similar chemicals causes intense cutaneous inflammatory response. However, morbidity mortality exposed population not only result damage but also a systemic injury. Here, we provide data delineating pathogenesis acute kidney injury...
Angiotensin II (Ang II) plays a major role in the pathogenesis of end-organ injury hypertension via its diverse hemodynamic and nonhemodynamic effects. Erythroblastosis virus E26 oncogen homolog-1 (ETS-1) is an important transcription factor recently recognized as mediator cell proliferation, inflammation, fibrosis. In present studies, we tested hypothesis that ETS-1 common renal proinflammatory profibrotic effects Ang II. C57BL6 mice (n=6 per group) were infused with vehicle (control), (1.4...