A5065115536- Iron Metabolism and Disorders
- Trace Elements in Health
- Hemoglobinopathies and Related Disorders
- Blood Coagulation and Thrombosis Mechanisms
- Neurological diseases and metabolism
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- RNA regulation and disease
- Angiogenesis and VEGF in Cancer
- Folate and B Vitamins Research
- RNA modifications and cancer
- Alzheimer's disease research and treatments
- Porphyrin Metabolism and Disorders
- Liver Disease Diagnosis and Treatment
- Biochemical and Molecular Research
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer-related gene regulation
- Histone Deacetylase Inhibitors Research
- Caveolin-1 and cellular processes
- Drug Transport and Resistance Mechanisms
- 14-3-3 protein interactions
- Mitochondrial Function and Pathology
- Cancer Treatment and Pharmacology
University of Brescia
2016-2025
Brescia University
2022
University of California System
2020
MRC Laboratory of Molecular Biology
2015
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2010
University of New Hampshire
2008
State University of New York
2008
University of New Hampshire at Manchester
2008
Mario Negri Institute for Pharmacological Research
2004-2006
University of Parma
2001
Abstract Hemochromatosis is a known cause of osteoporosis, and iron overload has deleterious effects on bone. Although its association with osteoporosis long been recognized, the pathogenesis exact role have undefined. Bone an active tissue constant remodeling capacity. Osteoblast (OB) development maturation are under influence core binding factor α-1 (CBF-α1), which induces expression OB-specific genes, including alkaline phosphatase, important enzyme in early osteogenesis, osteocalcin,...
Despite the prevalence and recognition of its detrimental impact, clinical complications sepsis remain a major challenge. Here, we investigated effects myeloid ferritin heavy chain (FtH) in regulating pathogenic sequelae sepsis. We demonstrate that deletion FtH leads to protection against lipopolysaccharide-induced endotoxemia cecal ligation puncture (CLP)-induced model as evidenced by reduced cytokine levels, multi-organ dysfunction mortality. identified such is predominantly mediated...
Ferritin is a widespread iron mineralizing and detoxification protein that stores as hydrous ferric oxide mineral core within shell-like structure of 4/3/2 octahedral symmetry. Iron mineralization initiated at dinuclear ferroxidase centers inside the where Fe2+ O2 meet react to form μ-1,2-peroxodiferric intermediate subsequently decays μ-oxo dimeric oligomeric iron(III) species ultimately core. Several types channels penetrate shell are possible pathways for diffusion dioxygen centers. In...
Vascular calcification plays a role in the pathogenesis of atherosclerosis, diabetes, and chronic kidney disease. Human aortic smooth muscle cells (HSMCs) undergo mineralization response to elevated levels inorganic phosphate (Pi) an active well-regulated process. This process involves increased activity alkaline phosphatase expression core binding factor alpha-1, bone-specific transcription factor, with subsequent induction osteocalcin. Mounting evidence suggests essential for heme...
Background Impaired regulation of hepcidin in response to iron is the cause genetic hemochromatosis associated with defects HFE and transferrin receptor 2. However, role these proteins expression unclear.Design Methods Hepcidin expression, SMAD extracellular signal-regulated kinase (Erk) phosphorylation furin were analyzed hepatic HepG2 cells which 2 down-regulated or expressed, activity specifically inhibited. Furin was also liver null mice.Results We showed that silencing reduced both Erk...
In animals, the iron storage and detoxification protein, ferritin, is composed of two functionally genetically distinct subunit types, H (heavy) L (light), which co-assemble in various ratios with tissue specific distributions to form shell-like protein structures 24 subunits within a mineralized core stored. The H-subunit possesses ferroxidase center (FC) that catalyzes Fe(II) oxidation, whereas L-subunit does not. To assess role oxidation formation, human recombinant heteropolymeric...
Abstract Iron has been implicated in the pathogenesis of age‐related retinal diseases, including macular degeneration (AMD). Previous work showed that intravitreal (IVT) injection iron induces acute photoreceptor death, lipid peroxidation, and autofluorescence (AF). Herein, we extend this work, finding surprising chronic features model: geographic atrophy sympathetic ophthalmia. We provide new mechanistic insights derived from focal AF photoreceptors, quantification bisretinoids,...
Prostate cancer (PCa) is a leading cause of death in the male population commonly treated with androgen deprivation therapy that often relapses as androgen-independent and aggressive castration-resistant prostate (CRPC). Ferroptosis recently described form cell requires abundant cytosolic labile iron to promote membrane lipid peroxidation which can be induced by agents inhibit glutathione peroxidase-4 activity such RSL3. Exploiting vitro vivo human murine PCa models multistage transgenic...
The antineoplastic compound aplidine, a new marine-derived depsipeptide, has shown preclinical activity in vitro on haematological and solid tumour cell lines. It is currently early phase clinical trials. exact mechanism of action this anticancer agent still needs to be clarified. We have previously reported that aplidine blocks the secretion angiogenic factor vascular endothelial growth (VEGF) by human leukaemia cells MOLT-4, suggesting possible effect angiogenesis. This study was designed...
Mitochondrial ferritin is a functional that localizes in the mitochondria. It expressed testis, heart, brain, and cells with active respiratory activity. Its overexpression cultured protected against oxidative damage reduced cytosolic iron availability. However, no overt phenotype was described mice inactivation of FtMt gene. Here, we used doxorubicin model cardiac injury novel strain FtMt-null to investigate antioxidant role FtMt. These did not show any evident phenotype, but after acute...