A5078762830- Advanced biosensing and bioanalysis techniques
- Recycling and utilization of industrial and municipal waste in materials production
- Computational Drug Discovery Methods
- DNA and Nucleic Acid Chemistry
- Phosphodiesterase function and regulation
- Click Chemistry and Applications
- Cholinesterase and Neurodegenerative Diseases
- X-ray Spectroscopy and Fluorescence Analysis
- Iron Metabolism and Disorders
- Trace Elements in Health
- SARS-CoV-2 and COVID-19 Research
- Chemical synthesis and alkaloids
- Coal and Its By-products
- Cannabis and Cannabinoid Research
- Polymer composites and self-healing
- Synthesis and biological activity
- Heavy metals in environment
- Soil Geostatistics and Mapping
- GABA and Rice Research
- Advanced X-ray Imaging Techniques
- Erythropoietin and Anemia Treatment
- Gold and Silver Nanoparticles Synthesis and Applications
- RNA Interference and Gene Delivery
- Nuclear Physics and Applications
- Aluminum toxicity and tolerance in plants and animals
University of Brescia
2016-2025
Elettra-Sincrotrone Trieste S.C.p.A.
2013-2024
University of Florence
2022
National Interuniversity Consortium of Materials Science and Technology
2012-2021
Brescia University
2013-2020
Vitenparken
2013
AREA Science Park
2013
University of Padua
2008-2011
Louvre
2006-2007
Centre de recherche et de restauration des musées de France
2006-2007
Emodin (1,3,8-trihydroxy-6-methyl-anthraquinone) is a moderately potent and poorly selective inhibitor of protein kinase CK2, one the most pleiotropic serine/threonine kinases, implicated in neoplasia other global diseases. By virtual screening MMS (Molecular Modeling Section) database, we have now identified quinalizarin (1,2,5,8-tetrahydroxyanthraquinone) as an CK2 that more than emodin. inhibition by competitive with respect to ATP, Ki value approx. 50 nM. Tested at 1 microM concentration...
Artemisia annua L. (AA) has shown for many centuries important therapeutic virtues associated with the presence of artemisinin (ART). The aim this study was to identify and quantify ART other secondary metabolites in ethanolic extracts AA evaluate biological activity an inflammatory stimulus. In work, after extraction aerial parts different concentrations ethanol, quantified by HPLC HPLC-MS. addition, anthocyanins, flavanols, flavanones, flavonols, lignans, low-molecular-weight phenolics,...
Graphene oxide/iron (III–VI) oxides nanocomposites have been produced with a fast and one-pot synthesis. K2FeO4 (Fe(VI)-based compound), obtained from dry synthesis, has used as green oxidant of graphite to produce graphene oxide, avoiding the use toxic permanganates. oxide flakes low oxidation degree decorated iron in one-step reaction. The material characterized by several techniques investigate structure (SEM, TEM analysis), composition (X-ray fluorescence, XPS, FTIR, UV–visible, Raman...
In the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) genome, open reading frames (ORFs) encode for viral accessory proteins. Among these, Orf7a structurally resembles members of immunoglobulin (Ig) superfamily and intracellular adhesion molecules (ICAMs), in particular. ICAMs are involved integrin binding through lymphocyte function-associated antigen 1 (LFA-1). Based on such considerations previous findings SARS-CoV, it has been postulated that formation LFA-1/Orf7a complex...
In this study, the agricultural digestate from anaerobic biogas production mixed with food wastes was used as a substrate to grow Trichoderma reesei RUT-C30 and atroviride Ta13 in solid-state fermentation (SSF) produce high-value bioproducts, such bioactive molecules be ingredients for biostimulants. The spp. reached their maximum growth after 6 3 SSF days, respectively. Both species were able cellulase, esterase, citric malic acids, while T. also produced gibberellins oxylipins shown by...
Municipal solid waste incineration (MSWI) is a straightforward way to manage waste, however the disposal of process byproducts, mainly bottom and fly ash, still problem, because their hazardous contents. Fly ash byproduct many other processes that involve combustion produce energy. In this paper we present discuss new method for MSWI inertization, based on use colloidal silica as stabilization agent metals. patented procedure, different provenance can be used an inert non-hazardous material,...
Abstract Casein kinase 2 (CK2) is a ubiquitous, essential, and highly pleiotropic protein kinase; its abnormally high constitutive activity suspected to underlie pathogenic potential in neoplasia other relevant diseases. Previously, using different silico screening approaches, two potent selective CK2 inhibitors were identified by our group: ellagic acid, naturally occurring tannic acid derivative ( K i =20 n M ) 3,8‐dibromo‐7‐hydroxy‐4‐methylchromen‐2‐one (DBC, =60 ). Comparing the...
Abstract Mutations in Pantothenate kinase 2 and Coenzyme A (CoA) synthase ( COASY ), genes involved CoA biosynthesis, are associated with rare neurodegenerative disorders brain iron accumulation. We showed that zebrafish pank2 gene plays an essential role vasculature development. Now we extended our study to coasy . The has high level of sequence identity the human ortholog is ubiquitously expressed from earliest stages abrogation its expression led strong reduction content, lethality a...
Cytoplasmic FMRP Interacting Protein 2 (CYFIP2) a component of the Wave Regulatory Complex (WRC), one most important players in regulating cellular actin dynamics. Interestingly, CYFIP2 transcript undergoes RNA editing, an epitranscriptomic modification catalysed by ADAR enzymes, that leads adenosine (A) to inosine (I) deamination. editing coding sequence results K/E substitution at amino acid 320. The functional meaning this regulation is still unknown. In study, we aim investigating...