A5072785722- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- Phosphodiesterase function and regulation
- Computational Drug Discovery Methods
- Free Radicals and Antioxidants
- Organoselenium and organotellurium chemistry
- Cholinesterase and Neurodegenerative Diseases
- Phytochemicals and Antioxidant Activities
- Bioactive Compounds and Antitumor Agents
- Click Chemistry and Applications
- Synthesis and biological activity
- RNA Interference and Gene Delivery
- Natural product bioactivities and synthesis
- SARS-CoV-2 and COVID-19 Research
- Chemical synthesis and alkaloids
- Cancer therapeutics and mechanisms
- Cannabis and Cannabinoid Research
- Chronic Lymphocytic Leukemia Research
- Neuroscience and Neuropharmacology Research
- Chemical Synthesis and Analysis
- Natural Antidiabetic Agents Studies
- Organic Chemistry Cycloaddition Reactions
- Synthesis and Biological Activity
- RNA and protein synthesis mechanisms
- Tryptophan and brain disorders
University of Brescia
2019-2025
Macau University of Science and Technology
2023
University of Florence
2022
University of Padua
2014-2021
Brescia University
2020
Centro de Investigación Biomédica en Red de Cáncer
2019
Pharmac
2015
Artemisia annua L. (AA) has shown for many centuries important therapeutic virtues associated with the presence of artemisinin (ART). The aim this study was to identify and quantify ART other secondary metabolites in ethanolic extracts AA evaluate biological activity an inflammatory stimulus. In work, after extraction aerial parts different concentrations ethanol, quantified by HPLC HPLC-MS. addition, anthocyanins, flavanols, flavanones, flavonols, lignans, low-molecular-weight phenolics,...
In the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) genome, open reading frames (ORFs) encode for viral accessory proteins. Among these, Orf7a structurally resembles members of immunoglobulin (Ig) superfamily and intracellular adhesion molecules (ICAMs), in particular. ICAMs are involved integrin binding through lymphocyte function-associated antigen 1 (LFA-1). Based on such considerations previous findings SARS-CoV, it has been postulated that formation LFA-1/Orf7a complex...
In this study, the agricultural digestate from anaerobic biogas production mixed with food wastes was used as a substrate to grow Trichoderma reesei RUT-C30 and atroviride Ta13 in solid-state fermentation (SSF) produce high-value bioproducts, such bioactive molecules be ingredients for biostimulants. The spp. reached their maximum growth after 6 3 SSF days, respectively. Both species were able cellulase, esterase, citric malic acids, while T. also produced gibberellins oxylipins shown by...
The oxidation of organic phenylselenides by H2 O2 is investigated in model compounds, namely, n-butyl phenyl selenide (PhSe(nBu)), bis(phenylselanyl)methane (PhSeMeSePh), diphenyl diselenide (PhSeSePh), and 1,2-bis(phenylselanyl)ethane (PhSeEtSePh). Through a combined experimental (1 H 77 Se NMR) computational approach, we characterize the direct monoselenide to selenoxide, stepwise double PhSeMeSePh that leads different diastereomeric diselenoxides, complete diphenyldiselenide...
While the neurochemistry that underpins behavioral phenotypes of depression is subject many studies, oxidative stress caused by inflammation comorbid with has not adequately been addressed. In this study, we described novel antidepressant-antioxidant agents consisting selenium-modified fluoxetine derivatives to simultaneously target serotonin reuptake (antidepressant action) and stress. Excitingly, show one these (
The uncontrolled hyperglycemia that characterizes diabetes mellitus (DM) causes several complications in the organism. DM is among major of deaths, and limited efficacy current treatments push search for novel drug candidates, also natural compounds. We focused our attention on caffeoylmalic acid, a phenolic derivative extracted from Urtica dioica, plant investigated its potential against type 2 DM. This compound was tested antidiabetic activity vitro through glucose uptake assay, vivo mouse...
Cytoplasmic FMRP Interacting Protein 2 (CYFIP2) a component of the Wave Regulatory Complex (WRC), one most important players in regulating cellular actin dynamics. Interestingly, CYFIP2 transcript undergoes RNA editing, an epitranscriptomic modification catalysed by ADAR enzymes, that leads adenosine (A) to inosine (I) deamination. editing coding sequence results K/E substitution at amino acid 320. The functional meaning this regulation is still unknown. In study, we aim investigating...
Organodiselenides are an important class of compounds characterized by the presence two adjacent covalently bonded selenium nuclei. Among them, diaryldiselenides and their parent compound diphenyl diselenide attract continuing interest in chemistry as well close disciplines like medicinal chemistry, pharmacology biochemistry. A search SCOPUS database has revealed that last three years 105 papers have been published on archetypal its use organic catalysis drug tests. The reactivity Se-Se bond...
Major depressive disorder is a psychiatric disease having approximately 20% lifetime prevalence in adults the United States (U.S.), as reported by Hasin et al. JAMA Psichiatry 2018 75, 336–346. Symptoms include low mood, anhedonia, decreased energy, alteration appetite and weight, irritability, sleep disturbances, cognitive deficits. Comorbidity frequent, patients show social functioning high mortality rate. Environmental genetic factors favor development of depression, but mechanisms which...
β-Cyclodextrin-functionalized silver nanoparticles were embedded within an alginate matrix to obtain hydrogels that capture, detect and remove organic pollutants from water.
The spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) caused a worldwide outbreak coronavirus disease 19 (COVID-19), which rapidly evolved as global concern. efforts the scientific community are pointed towards identification promptly available therapeutic options. RNA-dependent RNA polymerase (RdRp) is promising target for developing small molecules to contrast SARS-CoV-2 replication. Modern computational tools can boost and repurposing known drugs targeting RdRp. We...
Host cell invasion by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is mediated the interaction of viral spike protein (S) with human angiotensin-converting enzyme (ACE2) through receptor-binding domain (RBD). In this work, computational and experimental techniques were combined to screen antimalarial compounds from different chemical classes, aim identifying small molecules interfering RBD-ACE2 and, consequently, invasion. Docking studies showed that interfere same region...
The reactive oxygen species (ROS) scavenging capacities of ginkgolides and bilobalide, which are the peculiar constituents extract Ginkgo biloba, investigated in silico (level theory: (SMD)-M06-2X/6-311+G(d,p)//M06-2X/6-31G(d)). Unlike other popular antioxidant natural substances, carbon backbones these compounds entirely aliphatic exclusively single C–C bonds present. selectivity for alkoxyl radicals via hydrogen-atom transfer (HAT) is assessed; importantly, peroxyl also possible from a...