A5011544209- Metal complexes synthesis and properties
- Ferrocene Chemistry and Applications
- Asymmetric Hydrogenation and Catalysis
- Crystallography and molecular interactions
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Plant and Fungal Interactions Research
- Nutrition, Genetics, and Disease
- DNA and Nucleic Acid Chemistry
- Plant Disease Resistance and Genetics
- Microbial Metabolites in Food Biotechnology
- Lanthanide and Transition Metal Complexes
- Chemical Reaction Mechanisms
- Nanoparticle-Based Drug Delivery
- X-ray Diffraction in Crystallography
- Milk Quality and Mastitis in Dairy Cows
- Probiotics and Fermented Foods
- Biochemical and Molecular Research
- Plant Disease Management Techniques
- Drug Transport and Resistance Mechanisms
- Crystallization and Solubility Studies
- Biochemical Acid Research Studies
- Composting and Vermicomposting Techniques
- Protein Hydrolysis and Bioactive Peptides
- Magnetism in coordination complexes
- Plant Growth Enhancement Techniques
University of Brescia
2016-2023
University of Bari Aldo Moro
2014-2018
In this study, the agricultural digestate from anaerobic biogas production mixed with food wastes was used as a substrate to grow Trichoderma reesei RUT-C30 and atroviride Ta13 in solid-state fermentation (SSF) produce high-value bioproducts, such bioactive molecules be ingredients for biostimulants. The spp. reached their maximum growth after 6 3 SSF days, respectively. Both species were able cellulase, esterase, citric malic acids, while T. also produced gibberellins oxylipins shown by...
In bovine species, β-casein (β-CN) is characterized by genetic polymorphism. The two most common protein variants are β-CN A² (the original one) and A¹, differing from for one amino acid substitution (Pro67 to His67). Several bioactive peptides affecting milk nutritional properties can originate β-CN. Among them, β-casomorphin-7 (BCM7) ranging 60 66 be released more easily carrying His67 (A¹ type) instead of Pro67 (A² type). Nowadays, "A2 milk" produced in different countries claiming its...
Biodegradable, PEG-coated, nanoparticles (NPs) have gained therapeutic application as injectable colloidal systems for the controlled and site-specific release of drugs. In this paper, encapsulation in PLGA-PEG polymer NPs has been exploited to lower toxicity increase antitumor activity kiteplatin ([PtCl2(cis-1,4-DACH)]). Kiteplatin contains an isomeric form diamine ligand present oxaliplatin proved be particularly active against ovarian colon cancers. To favor platinum drug hydrophobic core...
DNA and mitochondria of tumor cells are the targets Pt(<sc>iv</sc>) complexes kiteplatin with biologically active dichloroacetate as axial ligands.
Abstract In this paper we investigate the possibility of further increase role N‐donor aromatic base in antitumor Hollis‐type compounds by conferring to act as a hydrogen‐bond donor/acceptor. Therefore, synthesized Pt II complex cis ‐[PtCl(NH 3 ) 2 (naph)]NO ( 1 containing 1,8‐naphthyridine (naph) ligand. The naphthyridine ligand is generally monodentate, and second nitrogen atom can H‐bond donor/acceptor depending upon its protonation state. forming such an could be crucial interaction drug...
The first Pt(IV) derivative of oxaliplatin carrying a ligand for TSPO (the 18-kDa mitochondrial translocator protein) has been developed. expression the protein in brain and liver healthy humans is usually low, oppositely to steroid-synthesizing rapidly proliferating tissues, where much more abundant. novel complex, cis,trans,cis-[Pt(ethanedioato)Cl{2-(2-(4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenoxy)acetate)-ethanolato}(1R,2R-DACH)] (DACH =...
Platinum(II) drugs are activated intracellularly by aquation of the leaving groups and then bind to DNA, forming DNA adducts capable activate various signal-transduction pathways. Mostly explored in recent years Pt(IV) complexes which allow presence two additional ligands axial positions suitable for attachment other cancer-targeting ligands. Here we have extended this strategy coordinating kiteplatin ([PtCl2(cis-1,4-DACH)], DACH = Diaminocyclohexane) its CBDCA (1,1-cyclobutanedicarboxylate)...
This study aims to produce a mix of enzymes through Solid State Fermentation (SSF) raw materials. Four different, easily available, agro-industrial wastes were evaluated as SSF substrates for production by Cryphonectria parasitica (Murr.) Barr. environmental strains named CpA, CpB2, CpC4, and CpC7. Among the tested wastes, organic wheat bran human use animal feed better supports C. growth protease without any supplements. SDS-PAGE analyses highlighted presence three bands corresponding an...