A5041195188- Free Radicals and Antioxidants
- Photochemistry and Electron Transfer Studies
- Biochemical effects in animals
- Organoselenium and organotellurium chemistry
- Advanced Chemical Physics Studies
- Metabolomics and Mass Spectrometry Studies
- Chemical Thermodynamics and Molecular Structure
- Molecular Spectroscopy and Structure
- Computational Drug Discovery Methods
University of Padua
2019-2020
Major depressive disorder is a psychiatric disease having approximately 20% lifetime prevalence in adults the United States (U.S.), as reported by Hasin et al. JAMA Psichiatry 2018 75, 336–346. Symptoms include low mood, anhedonia, decreased energy, alteration appetite and weight, irritability, sleep disturbances, cognitive deficits. Comorbidity frequent, patients show social functioning high mortality rate. Environmental genetic factors favor development of depression, but mechanisms which...
Zolpidem (N,N-Dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide) is a well-known drug for the treatment of sleeping disorders. Recent literature reports on positive effects zolpidem therapy improving renal damage after cisplatin and reducing akinesia without sleep induction. This has been ascribed to antioxidant neuroprotective capacity this molecule, tentatively explained according generic structural similarity between melatonin. In work, we investigate in silico...
Many natural substances and drugs are radical scavengers that prevent the oxidative damage to fundamental cell components. This process may occur via different mechanisms, among which, one of most important, is hydrogen atom transfer. The feasibility this can be assessed in silico using quantum mechanics compute ΔGHAT○. approach accurate, but time consuming. use machine learning (ML) allows us reduce tremendously computational cost assessment scavenging properties a potential antioxidant,...
The interest in diphenyl ditelluride (Ph2Te2) is related to its strict analogy diselenide (Ph2Se2), whose capacity reduce organic peroxides largely exploited catalysis and green chemistry. Since the latter also a promising candidate as an antioxidant drug mimic of ubiquitous enzyme glutathione peroxidase (GPx), use organotellurides medicinal chemistry gaining importance, despite fact that tellurium has no recognized biological role toxicity must be cautiously pondered. Both Ph2Se2 Ph2Te2...