A5054953850- Natural Antidiabetic Agents Studies
- Nuts composition and effects
- Liver Disease Diagnosis and Treatment
- African Botany and Ecology Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Global Maternal and Child Health
- Child Nutrition and Water Access
- Bioactive Compounds and Antitumor Agents
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Plant biochemistry and biosynthesis
- Dietary Effects on Health
- Ethnobotanical and Medicinal Plants Studies
- Tannin, Tannase and Anticancer Activities
- Hibiscus Plant Research Studies
- Phytochemicals and Antioxidant Activities
- HIV/AIDS Impact and Responses
- Antiplatelet Therapy and Cardiovascular Diseases
- Biochemical and Molecular Research
- Marine Sponges and Natural Products
- Traditional and Medicinal Uses of Annonaceae
- Bioactive Compounds in Plants
- Advanced Glycation End Products research
- Sulfur Compounds in Biology
- Medicinal plant effects and applications
Baqai Medical University
2018-2025
Hamdard University
2020
Karachi Medical and Dental College
2020
Abbasi Shaheed Hospital
2020
Dow University of Health Sciences
2020
The uncontrolled hyperglycemia that characterizes diabetes mellitus (DM) causes several complications in the organism. DM is among major of deaths, and limited efficacy current treatments push search for novel drug candidates, also natural compounds. We focused our attention on caffeoylmalic acid, a phenolic derivative extracted from Urtica dioica, plant investigated its potential against type 2 DM. This compound was tested antidiabetic activity vitro through glucose uptake assay, vivo mouse...
Glioblastoma multiforme (GBM) poses significant challenges due to its aggressiveness and resistance standard therapies, necessitating novel treatments. This study evaluates the anticancer potential of flavonoids isolated from Pistacia chinensis against glioblastoma U87 cell line. Two flavonoids, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one (Compound 1) 2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-3-methoxy-4H-chromen-4-one 2), were using column chromatography analyzed through in silico...
Journal of Computational Biophysics and ChemistryAccepted Papers No AccessDual Therapeutic Potential Novel Cornallegic acid: In Vitro Anti-Inflammatory ROS Suppression with Insights from Docking, ADMET, DFT StudiesWali Ullah, Ghias Uddin, Abdur Rauf, Muhammad Umer Khan, Zuneera Akram, Chaudhry Ahmed Shabbir, Walaa F. Alsanie, Abdulhakeem S. Alamri, Marcello IritiWali Uddin Search for more papers by this author , Rauf Khan Akram Shabbir Alsanie Alamri...
Abstract Cancer is one of the most demanding domains for innovative, effective, safe, and affordable therapeutically active chemicals. The main aim this study to research new phytochemicals with anticancer activity. current experiment identified analyzed six compounds anti-cancer potential supported by molecular simulation studies. defatted methanolic extract underwent column chromatography, resulting in isolation flavonoids. These include 3,5,7,4′-tetrahydroxy-flavanone ( 1 ), naringenin 2...
Objective: This study was aimed to establish the prevalence of overweight, obesity and related its factors among citizens Karachi.
 Methodology: From Jan 2018 August 2018. cross-sectional analysis conducted obtain information from 772 persons using a validated questionnaire traditional height weight evaluation methods have been used. Overweight were described by South Asian cut-off points as 23 ≥ BMI (Normal), 25.0 - 29.9 (Overweight) 30 ≤ (Obese) respectively. For data processing,...
Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) regulates skeletal and soft tissue mineralization by hydrolyzing nucleotide triphosphates cyclic nucleotides, is involved in the modulation of immune system. In fact, ENPP1 degrades 2′,3′-cyclic GMP-AMP dinucleotide (2′,3′-cGAMP), which an agonist surface receptor stimulator interferon genes (STING), thus downregulating response. Consequently, inhibitors are being studied as adjuvant agents infections cancer. Pistacia chinensis a...
Low birth weight (LBW) is linked with fetal and neonatal mortality morbidity; also it can slow down growth cognitive development. Several factors contribute to pregnancy outcomes, including LBW deliveries, maternal nutrition, additional dietary intake. Our study was aimed identify the frequency associated mothers in Karachi, Pakistan. Methods: A cross-sectional survey carried out at Obstetrics Gynaecological Department of Hamdard Hospital, Karachi. total 195 healthy pregnant females were...
Background: Pistacia chinensis is extensively employed in traditional medicine. This study aimed to isolate and evaluate the therapeutic effects of 3’4’78-tetrahydroxy-3-methoxyflavone from P. crude extract. Materials Methods: The utilized column chromatography for isolation. plant extract its isolated compound were assessed vivo analgesic (hot plate model), anti-inflammatory (carrageenan-induced paw edema), sedative (open field muscle relaxing properties (inclined plane traction test)....
Abstract In this work, iron oxide nanoparticles (IONPs) were synthesized using green methods. The structural morphological and optical properties of (NPs) investigated by scanning electron microscopy (SEM), X-ray diffraction (XRD), ultraviolet–visible spectroscopy, Fourier transform infrared spectroscopy. Based on the SEM analysis, spherical NPs with a size distribution in range 50–70 nm simulated slight variations shapes, corresponding XRD was calculated. calculated patterns then averaged....
Pistacia chinensis is locally practiced for treating diabetes, pain, inflammation, and erectile dysfunction. Therefore, the current studies subjected crude extract/fractions isolated compound (2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-3-methoxy-4H-chromen-4-one) to α‐glucosidase inhibitor anti-glycation activities. The development of long-term complications associated with diabetes primarily caused by chronic hyperglycemia. Regarding α‐glucosidase, most significant inhibitory effect was observed...
Background: The ninth month of the Islamic calendar is Ramadan, during which Muslims fast from dawn till sunset. This extended fasting period may affect management diabetes in diabetic people. study aimed to compare number visitors Emergency Room (ER) a private tertiary care hospital FB Area, Karachi, Pakistan, throughout Ramadan and other lunar months, with emergencies. Methodology: A retrospective cross-sectional was conducted utilizing an electronic medical record review patients...
Riboflavin (RF) sensitized photooxidation of pyridoxine HCl (PD) in the pH range 2.0-12.0 has been carried out under UV and visible irradiation aerobic anaerobic conditions. PD follows first-order kinetics absence presence RF for its photodegradation. The rate constants (
Pistacia chinensis is used as a decorative tree and currently studied source of biofuels. Besides, its parts extracts are endowed with several therapeutic uses which have been widely explored in traditional medicine that related to rich composition phytochemicals. Molecular docking enzymatic inhibition tests were study the activity eriodictyol, flavonoid extracted from barks P. chinensis, against ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) aldose reductase (ALR2). The compound...
Introduction: Diabetes is the most genetically transmitted disease all over theworld. It badly affects vital organs and manifest reduction of pancreatic amylase andlipase. Objectives: This study has been designed to investigate role Guaiacum officinaleextract in controlling diabetes streptozotocin (STZ) induced type 2 male albino(Wistar) rats. Study Design: Experimental. Setting: Baqai Medical University. Period: January2017- June 2017. Method: Bark extract officinale (500mg/kg) was...
Diabetes mellitus has high global prevalence and occurrence is considered to bean endocrinological and/or metabolic disorder. Conventional drug treatment costly toxic side effects, although it successful in treating diabetes mellitus. If effective less toxic, herbal medicine will thus include alternative therapy. This research been designed investigate the role of Grewia asiatica extract control male albino rats with Streptozotocin mediated type 2 diabetes. fruit at a dose 200mg/kg was given...