A5111543781- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Obstructive Sleep Apnea Research
- Atherosclerosis and Cardiovascular Diseases
- Blood Pressure and Hypertension Studies
- Neuroscience of respiration and sleep
- Heart Rate Variability and Autonomic Control
- Inflammatory Biomarkers in Disease Prognosis
- Adipokines, Inflammation, and Metabolic Diseases
- Acute Ischemic Stroke Management
- Cardiovascular and Diving-Related Complications
- Paraoxonase enzyme and polymorphisms
- Nitric Oxide and Endothelin Effects
- Venous Thromboembolism Diagnosis and Management
- Antioxidant Activity and Oxidative Stress
- Cardiac Health and Mental Health
- Migraine and Headache Studies
- Dementia and Cognitive Impairment Research
- Biomarkers in Disease Mechanisms
- Cardiovascular Disease and Adiposity
- EEG and Brain-Computer Interfaces
- Protease and Inhibitor Mechanisms
- Ophthalmology and Eye Disorders
- Cardiovascular Issues in Pregnancy
- Blood properties and coagulation
National Healthcare Service Center
2025
University of Debrecen
2007-2019
Semmelweis University
2008
Abstract Purpose Obstructive sleep apnea-hypopnea syndrome (OSAHS) is the most common sleep-related breathing disorder. Longer term, repeated episodes of hypercapnia and hypoxemia during are associated with inflammatory atherosclerosis-related factors. The aim this study was to explore effect continuous positive airway pressure (CPAP) therapy on cerebral vasoreactivity early atherosclerosis in patients severe OSAHS. Methods Forty-one OSAHS were enrolled. mean follow-up time 39.8 ± 9.1...
Background and Purpose— Several factors have been held responsible for the development of atherosclerosis. To avoid masking effect age, we evaluated correlates carotid atherosclerosis in patients <55 years age. Methods— Plasma lipids, oxidative resistance low-density lipoprotein, homocysteine, inflammatory markers, plasma viscosity, red cell deformability were measured fasting blood samples 100 subjects: 45 with >30% stenosis internal artery, 20 occlusion, 35 control subjects. Stenosis...
The role of platelets in the development atherosclerosis and obesity-related prothrombotic state is still under investigation. In this cross-sectional cohort study, we measured levels different platelet activation markers evaluated their relationship with carotid intima-media thickness (IMT) along other atherosclerotic risk factors obese patients or without co-morbidities. We enrolled 154 patients, including 98 either hypertension, type 2 diabetes mellitus dyslipidaemia, 56 these...
QT interval (QT) and dispersion (QTd) are electrocardiograph (ECG) parameters for the evaluation of myocardial repolarization. The inhomogeneity ventricular repolarization is associated with arrhythmias. An increased QT, QTd, incidence nocturnal cardiac rhythm disturbances have been described in patients obstructive sleep apnea (OSA), while other investigators did not find a relationship between arrhythmias OSA.The aim this study was to examine occurrence measure untreated OSA using an...
The aim of the present study was to investigate association between cardiovascular risk factors and endothelial dysfunction in patients with mixed connective tissue disease (MCTD) determine which biomarkers are associated atherosclerotic complications, such as disease.
We present imaging evidence of the spreading cortical edema with reversibly restricted water diffusion from left occipital to temporoparietal cortex in persistent visual migraine aura a 58-year-old man. The right-sided field defect lasting for 15 days was associated discoupling glucose metabolism and blood flow decreased apparent coefficient also suggested cytotoxic edema. At 8 weeks no signs were present, magnetic resonance became normal; therefore, long-lasting diffusion, even if coupled...
Carotid bruits are supposed to indicate the presence of high-grade common carotid or extracranial internal artery stenosis in a large proportion patients. Using stethoscope, we prospectively auscultated 273 arteries 145 patients blinded results complete and intracranial Doppler investigation including color-coded duplex ultrasound. Fifty-four showed ≥ 50%-99%, occlusion artery. In 25 these arteries, bruit was present. 9 out 16 with from 70%-99%, detected. one additional patient middle-grade...
<i>Background:</i> Asymmetric dimethylarginine (ADMA) assumes a significant role in atherosclerosis by inhibiting the endothelial nitric oxide synthase (eNOS). Moreover, ADMA inhibits inducible NOS (iNOS), isoform that triggers via peroxynitrite formation. Therefore, we investigated whether is risk or protective factor atherosclerotic process. Intima-media thickness (IMT) of common carotid artery, surrogate for vascular diseases, was chosen as outcome variable interest....
<i>Background:</i> Human serum paraoxonase (PON1) protects lipoproteins against oxidation by hydrolyzing lipid peroxides in oxidized low-density lipoprotein (oxLDL); therefore, it may protect atherosclerosis. PON1 activity and polymorphisms have been inconsistently associated with carotid artery disease. The goal of this study was to clarify the role phenotype on disease its correlation some inflammatory immune markers subjects under 55 years early-onset...
Mannose-binding lectin (MBL) activates complement system and has been suggested to play a role in vascular complications diabetics. Carotid intima-media thickness (cIMT) detects subclinical atherosclerosis. We evaluated the association of MBL IMT type 2 diabetic (T2DM) patients.Serum levels cIMT were measured total 103 diabetics 98 age-matched healthy controls.There was no significant difference level T2DM versus controls. As expected, significantly higher patients than controls (P = 0.001)....
Objective: Soluble CD40 ligand (sCD40L) has been suggested as a key mediator between inflammation and atherosclerosis, the CD40‐CD40L interaction role in atherosclerotic lesion progression. We evaluated if platelet released serum sCD40L sCD40 levels differ patients with early onset occlusive carotid artery disease age‐matched controls. Methods: were measured samples of 60 30 controls using ELISA. Degree stenosis internal (ICA), intima‐media thickness (IMT) common by high resolution...
Both myocardial infarction and ischemic stroke are rare in the young. Yet a 15-year-old male patient suffered later an despite uninterrupted antiplatelet therapy. His medical history involved surgical correction of incomplete atrioventricular canal defect at age 13 years. No cardiovascular risk factors other than elevated lipoprotein(a) level could be identified. antithrombin (AT) activity was decreased DNA sequence analysis revealed heterozygosity for AT Basel (p.Pro41Leu), variant with...
Objective. The role of serum cholesterol and triglycerides in carotid artery atherosclerosis is controversial. We measured intima-media thickness (IMT), a marker subjects younger than 55 years age with 6-fold range levels (3.93–25.03 mmol/L) 200-fold triglyceride (0.36–75.97 mmol/L). Methods. Eighty-six patients increased lipid values 30 normal were included. Serum lipids after an overnight fast. High-resolution sonographic investigations the arteries all videotaped. Intima-media was offline...
<i>Purpose:</i> To evaluate the diagnostic value of a combined method, i.e. ergometer cycling with continuous bilateral transcranial Doppler monitoring (TCD) to detect cerebral hemodynamic abnormalities in recently diagnosed hypertensive patients. <i>Methods:</i> 30 neurologically symptom-free, nontreated patients essential hypertension and age- sex-matched controls were studied. Carotid ultrasound, resting ECG blood parameters investigated. Cycling ergometry was...
Previously, 30 untreated hypertensive patients were investigated by transcranial Doppler (TCD) monitoring during physical exercise, and changes of hemodynamic parameters compared with those age matched healthy subjects. After 3-year antihypertensive (AHT) treatment, these hypertensives again. The aim this study was to compare the cerebral in regularly treated noncompliant (untreated) ergometer cycling.Nineteen previously could be again using same method as before. Eleven (treated [T-HT]...