A5028471884- Corneal Surgery and Treatments
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Corneal surgery and disorders
- Intraocular Surgery and Lenses
- Retinal Imaging and Analysis
- Retinal and Macular Surgery
- Retinal and Optic Conditions
- Retinal Development and Disorders
- Ophthalmology and Visual Impairment Studies
- Herpesvirus Infections and Treatments
- Mesenchymal stem cell research
- Ocular Infections and Treatments
- Ocular Oncology and Treatments
- Phagocytosis and Immune Regulation
- Blood properties and coagulation
- Salivary Gland Disorders and Functions
- Nanoplatforms for cancer theranostics
- Advanced Drug Delivery Systems
- Biomedical Research and Pathophysiology
- Inflammatory Biomarkers in Disease Prognosis
- Blood Coagulation and Thrombosis Mechanisms
- Hemostasis and retained surgical items
- Drug-Induced Ocular Toxicity
University of Szeged
2013-2022
SeqOmics Biotechnology (Hungary)
2020
University of Debrecen
1998-2013
Medical University of Vienna
2007
An international, expert-led consensus initiative to develop systematic, evidence-based recommendations for the treatment of noninfectious uveitis in era biologics.The availability biologic agents human eye disease has altered practice patterns management uveitis. Current guidelines are insufficient assure optimal use noncorticosteroid systemic immunomodulatory agents.An international expert steering committee comprising 9 specialists (including both ophthalmologists and rheumatologists)...
The role of platelets in the development atherosclerosis and obesity-related prothrombotic state is still under investigation. In this cross-sectional cohort study, we measured levels different platelet activation markers evaluated their relationship with carotid intima-media thickness (IMT) along other atherosclerotic risk factors obese patients or without co-morbidities. We enrolled 154 patients, including 98 either hypertension, type 2 diabetes mellitus dyslipidaemia, 56 these...
Abstract Corneal tissue regeneration is of crucial importance for maintaining normal vision. We aimed to isolate and cultivate human corneal stroma-derived mesenchymal stem-like cells (CSMSCs) from the central part cadaver corneas study their phenotype, multipotency, role in immunity wound healing. The isolated grew as monolayers vitro , expressed mesenchymal- stemness-related surface markers (CD73, CD90, CD105, CD140b) were negative hematopoietic determined by flow cytometry. CSMSCs able...
Retinal pigment epithelial (RPE) cells can undergo different forms of cell death, including autophagy-associated death during age-related macular degeneration (AMD). Failure macrophages or dendritic (DCs) to engulf the dying in retina may result accumulation debris and progression AMD. ARPE-19 primary human RPE upon serum depletion oxidative stress induced by hydrogen peroxide (H2O2). Autophagy was revealed elevated light-chain-3 II (LC3-II) expression electron microscopy, while autophagic...
The transient receptor potential vanilloid 1 (TRPV1) plays a role in the activation of sensory neurons by various painful stimuli and is therapeutic target. However, functional TRPV1 that affect microvascular diameter are also expressed peripheral arteries we attempted to characterize this receptor.Sensory was measured rats use an eye wiping assay. Arteriolar TRPV1-mediated smooth muscle specific responses (arteriolar diameter, changes intracellular Ca(2+)) were determined isolated,...
Abstract Background Female-limited early-onset high myopia, also called Myopia-26 is a rare monogenic disorder characterized by severe short sightedness starting in early childhood and progressing to blindness potentially the middle ages. Despite X-linked locus of mutated ARR3 gene, disease paradoxically affects females only, with males being asymptomatic carriers. Previously, this has only been observed Asian families not gone through detailed investigation concerning collateral symptoms or...
The release of different cytokines and mediators in tears patients with keratoconus (KC) wearing contact lenses (CLs) may contribute to the pathology KC.Cohort study was established KC rigid gas permeable (RGP) CL (group I), ametropia silicone hydrogel (Si-Hi) II) ametropic RGP III).Our findings indicate that before wear, epidermal growth factor (EGF) tissue-type plasminogen activator (t-PA) attenuated, whereas matrix metalloproteinase (MMP)-9, interleukin (IL)-6, chemokine (C-C motif)...
Abstract. Purpose: Protein C is a major component of the natural anticoagulant pathway. Resistance coagulation factor V (FV) to activated protein (APC), mostly due FV Leiden mutation, most common cause inherited thrombophilia. The aim this retrospective study was determine prevalence APC resistance and mutation in patients with non‐arteritic anterior ischaemic optic neuropathy (NAION). Methods: A total 25 NAION were examined between 1997 2002. screened for as well acquired risk factors...
Long-term cultures of cornea limbal epithelial stem cells (LESCs) were developed and characterized for future tissue engineering clinical applications. The explants cultivated expanded more than 3 months in medium containing serum as the only growth supplement without use scaffolds. Viable 3D cell outgrowth from was observed within 4 weeks cultivation. outgrowing examined by immunofluorescent staining putative markers stemness (ABCG2, CK15, CK19 Vimentin), proliferation (p63α, Ki-67), basal...
Introduction. Diabetic retinopathy (DR) is a sight-threatening complication of diabetes. Telemedicine tools can prevent blindness. We aimed to investigate the patients’ satisfaction when using such (fundus camera examination) and effect demographic socioeconomic factors on participation in screening. Methods. Pilot study involving fundus screening self-administered questionnaire participants’ experience during examination (comfort, reliability, future interest participation), as well was...
A non-interventional, multicenter, European, prospective evaluation of the effectiveness, tolerability, and safety a topical preservative-free tafluprost (0.0015%) timolol (0.5%) fixed-dose combination (PF tafluprost/timolol FC) in adults with open-angle glaucoma (OAG) ocular hypertension (OHT) demonstrating insufficient response to beta-receptor blockers or prostaglandin analogue (PGA) monotherapy. Mean intraocular pressure (IOP) change from baseline was measured at study visits following...
Ingestion of sulphonamide-derived drugs has been reported to possibly have ocular side-effects. Authors aimed present a rare case indapamide-induced transient myopia with ciliary body edema and supraciliary effusion.A 39 years old caucasian female patient presented at the Department Neurology headache sudden bilateral loss distant vision. Neurological assessment cranial CT scans were unremarkable. For her hypertension, twice day bisoprolol 2.5 mg once indapamide 1.5 tablets prescribed...
Purpose: The formulation of topical ophthalmic products with appropriate therapeutic effect and patient compliance is a major challenge. To increase the efficiency ocular delivery drug, enhancement water solubility contact time drug on surface cornea are necessary. In this work, prednisolone (PR)-containing eye drops were formulated antimicrobial, mucoadhesive biopolymer PR–cyclodextrin inclusion complex. This approach can be used for development innovative formulations. Materials methods:...
<i>Objective:</i> To determine the levels of interleukin 6 (IL-6) and 8 (IL-8/CXCL-8) in tears collected from eyes normal individuals patients with different irritative eye diseases, order to acquire information on immunological changes occurring during early postoperative period following various forms surgery, including penetrating keratoplasty (PKP). <i>Methods:</i> IL-6 IL-8 were measured aid human ultrasensitive ELISA kits non-stimulated PKP or cataract...
Purpose: The identification of cells with properties retinal progenitor (RPCs) in the adult human ciliary margin (CM) prompted a number studies their proliferative and differentiation potential. One remaining challenges is to find feasible method isolating RPCs from patient's eye. In CM, only iris pigment epithelium (IPE) easily obtained by minimally invasive procedure. light recent questioning existence mammalian we wanted assess potential IPE as source RPCs. Methods: were isolated...
To identify changing trends in indications for corneal transplantation Debrecen, Hungary over the past 64 years.Retrospective study, at Department of Ophthalmology, University Hungary.Four thousand seven hundred and seventy-eight patients who underwent keratoplasty.The analysis was based on medical charts, surgical descriptions eye bank records.Keratoplasty between January 1946 December 2009. For an easier overview, 64-year interval divided into time periods (1946-1955, I; 1956-1965, II;...
A novel, simple, and reproducible method for cultivating pathological tissues obtained from human eyes during surgery was developed using viscoelastic material as a tissue adherent to facilitate cell attachment expansion calcium imaging of cultured cells challenged by mechanical acetylcholine (ACh) stimulation well inflammatory studies. Anterior lens capsule-lens epithelial (aLC-LECs) cataract proliferative diabetic retinopathy (PDR) fibrovascular epiretinal membranes (fvERMs) were used in...