A5087188904- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal and Macular Surgery
- Intraocular Surgery and Lenses
- Retinal and Optic Conditions
- Ocular Surface and Contact Lens
- Corneal surgery and disorders
- Retinal Development and Disorders
- Ophthalmology and Eye Disorders
- Ocular Diseases and Behçet’s Syndrome
- Ocular and Laser Science Research
- Ophthalmology and Visual Impairment Studies
- Ocular Infections and Treatments
- Vascular Malformations Diagnosis and Treatment
- Neurological Disorders and Treatments
- Vasculitis and related conditions
- Rabies epidemiology and control
- Traumatic Ocular and Foreign Body Injuries
- Connexins and lens biology
- Corneal Surgery and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Facial Trauma and Fracture Management
- Barrier Structure and Function Studies
- Academic Publishing and Open Access
Azienda Ospedaliero Universitaria Maggiore della Carita
2015-2025
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2016-2025
Ospedale Maggiore
2015-2024
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2015-2024
Ophthalmology Associates (United States)
2020
Piedmont University
2019
Azienda Ospedaliera Ospedale Maggiore
2018
Ospedale San Paolo
2007-2016
University of Milan
2008-2016
Hallym University Dongtan Sacred Heart Hospital
2016
To investigate whether oxidative stress modulates vascular endothelial growth factor (VEGF)-A and VEGF-C expression polarized secretion in a human retinal pigment epithelium cell line (ARPE-19).Long-term culture of ARPE-19 cells Dulbecco's modified Eagle medium (DMEM)/F12 containing 1% fetal bovine serum (FBS) on transwell filters (12 mm or 6 mm, pore size 0.4 microm) was performed to produce (RPE) monolayers. The integrity monolayer established by measurement transepithelial resistance...
To evaluate the strength and pattern of relationship between visual field (VF) sensitivity retinal nerve fiber layer (RNFL) thickness measurements by scanning laser polarimetry (SLP).Fifty-four eyes 54 normal subjects (age, 42 +/- 15 years; VF mean deviation [MD], -0.69 1.01 dB) 51 glaucoma patients 66 14 MD, -6.92 5.43 were imaged with an SLP using fixed corneal compensation (FCC) variable (VCC). was recorded in dB 1/L scales. Linear logarithmic relationships sought globally six sectors....
To assess and compare early modifications in inner retinal layer thickness optical coherence tomography angiography parameters patients with diabetes mellitus (DM) Types 1 2 without clinical signs of diabetic retinopathy.Ninety eyes 90 subjects (24 Type DM, 36 30 healthy controls) were prospectively evaluated spectral domain OCT, swept-source OCT angiography, color fundus photography (on the same day). Retinal nerve fiber layer, ganglion cell (GCL+), + GCL+ (GCL++) automatically determined...
Purpose: To evaluate peripapillary vessel density and morphology in patients with diabetes mellitus (DM) without clinical signs of diabetic retinopathy (DR) mild, nonproliferative DR to correlate nerve fiber layer (NFL) thickness. Methods: One hundred seventeen eyes (34 healthy controls, 54 DM [noDR group] 24 mild [DR group]) were prospectively evaluated. All subjects underwent macular optical coherence tomography angiography (OCT-A). Peripapillary NFL thickness was also recorded. OCT-A slab...
To study the subbasal corneal plexus (SCP) in patients with diabetic retinopathy (DR) treated or nontreated panretinal Argon laser photocoagulation (ALP).Fifty consecutive DR and 50 age- sex-matched normal control subjects were examined retinal tomography by a masked evaluator. The following nerves parameters considered: number per frame, tortuosity, reflectivity. Diabetic divided into two groups, according to presence of proliferative versus nonproliferative retinopathy, Early Treatment...
To evaluate frequency, conversion rate, and risk factors for blindness in glaucoma patients treated European Universities.This multicenter retrospective study included 2402 consecutive with at least one eye. Medical charts were inspected divided into those blind the remainder ('controls'). Blindness was defined as visual acuity≤0.05 and/or field loss to less than 10°.Unilateral bilateral respectively 11.0% 1.6% beginning, 15.5% 3.6% end of observation period (7.5±5.5 years, range:1-25...
Optical coherence tomography angiography (OCT-A) has recently improved the ability to detect subclinical and early clinically visible microvascular changes occurring in patients with diabetes mellitus (DM). The aim of present study is evaluate compare quantitative macular perfusion parameters DM without DR mild nonproliferative (NPDR) evaluated by two different swept-source (SS) OCT-A instruments using scan protocols (3 × 3 mm 6 mm). One hundred eleven subjects/eyes were prospectively...
Purpose: To determine whether surgical manipulation steps of the internal limiting membrane (ILM) flap, such as ILM trimmed, tuck inside hole, massage, are mandatory to obtain satisfactory outcomes for repair large stage IV idiopathic macular hole using inverted flap technique. Methods: In this interventional comparative prospective single-masked study, 81 eyes were randomized into 2 treatments groups. Group 1 (41 eyes), classic technique was performed. (40 a modified procedure used: after...
Précis: Deep sclerectomy (DS) and canaloplasty provide better intraocular pressure (IOP) control than viscocanalostomy. DS required less glaucoma medications but more interventions to reach target IOP. Purpose: To compare real-world outcomes of three non-penetrating surgery (NPGS) techniques. Methods: Retrospective, cohort study consecutive patients undergoing (CP), deep (DS), viscocanalostomy (VC), across nine European units. Four criteria were used define success at 2-year follow-up:...
To study clinical and in vivo laser scanning confocal microscopy (LSCM) ocular surface findings stable, medically controlled primary open-angle glaucoma (MCPOAG) patients.We recruited 100 consecutive patients with MCPOAG 50 healthy controls. Patients had to have been treated the same medical regimen without variation for 18 months before enrollment were excluded if there was a history of dry eye prior diagnosis. Each participant underwent LSCM examination.In patients, subbasal nerve length...
Purpose: To assess changes on optical coherence tomography (OCT) angiography in diabetic macular edema (DME) treated with subthreshold micropulse yellow laser (SMPL) over a period of 6 months. Methods: Thirty-five eyes (35 consecutive patients) treatment-naive DME prospectively underwent (at baseline, 3 and months) best-corrected visual acuity, swept-source OCT angiography/OCT, fundus autofluorescence. Following parameters were evaluated the superficial capillary plexus (SCP) deep (DCP):...
Purpose: The aim of this study was to evaluate 1-year quantitative changes in specific inflammatory parameters on optical coherence tomography (OCT) / angiography (OCTA) diabetic macular edema (DME) treated with subthreshold micropulse laser (SMPL). Methods: Thirty-seven patients eyes previously treatment-naïve DME SMPL were prospectively evaluated at 3, 6, and 12 months. Fifteen fellow only microaneurysms (MAS) not eligible for treatment controls. Evaluated OCT OCTA included: central...
The purpose of this comparative cross-sectional study was to investigate the use standardized clinical tests for dry eye in pediatric patients with active and quiet vernal keratoconjunctivitis (VKC) compare them healthy children.We recruited 35 VKC, inactive 70 age-matched control subjects. Each child underwent a complete examination, including visual analog scale symptoms assessment, biomicroscopy, fluorescein break-up time (BUT), corneal conjunctival lissamine green staining,...
Aims To evaluate Compass, a new instrument for glaucoma screening and diagnosis that combines scanning ophthalmoscopy, automated perimetry, eye tracking. Materials Methods A total of 320 human subjects (200 normal, 120 with glaucoma) underwent full ophthalmological evaluation perimetric using the Humphrey SITA standard 24° test (HFA), Compass consisted full-threshold program on central photograph 30° retina. subgroup normal patients second during same day in order to study test-retest...
Purpose: To investigate, in pediatric patients, the rate and clinical features of unspecific conjunctivitis unknown origin (UCUO) to evaluate their relationship with air pollution. Methods: From January December 2013, we consecutively screened all patients referred for symptomatic ocular surface inflammation. Inclusion criteria this study were age<14, diagnosis conjunctivitis, residence Lombardia region. UCUO was defined as etiology, not clearly due infection or allergy. Based on addresses...
To evaluate corneal subbasal layer changes after uneventful cataract surgery by means of in vivo confocal microscopy.This prospective study included 30 patients. Before surgery, and 1, 3, 6, 8 10 months all patients underwent a complete ophthalmological microscopy examination the central temporal areas. Number fibers, beading, tortuosity reflectivity were analyzed.Important shown cornea up to 3 surgery: reduction nerve fiber number (baseline: 4.4 ± 1.7; month 1: 1.2 0.5, p < 0.0001; 3: 2.5...
The aim of the present study was to compare confocal and clinical features newly diagnosed glaucoma patients receiving unpreserved prostaglandins (tafluprost) versus preserved (latanoprost). 40 were randomized tafluprost 0.0015% (20 patients; 32 eyes) or latanoprost 0.005% + benzalkonium chloride 0.02% 35 once daily for 1 year. Inclusion criteria new diagnosis, no ocular treatments 6 months before study. Patients evaluated at baseline every 3 with a complete ophthalmologic evaluation,...
Subthreshold micropulse laser (SMPL) has been increasingly used for the treatment of different retinal and choroidal macular disorders. However, exact mechanisms action have not yet clearly defined. Therefore, we aimed to examine role SMPL in modulation oxidant/antioxidant systems, apoptosis autophagy mice eyes.A specific contact lens retina was positioned on cornea 40 (20 young 20 old) order focus eye fundus treatment. Within 6 months, animals received one only, whereas others were treated...
Abstract Purpose To investigate choriocapillaris ( CC ) perfusion, by evaluating flow voids FV ), in eyes with intermediate age‐related macular degeneration iAMD using swept‐source optical coherence tomography angiography SS ‐ OCT ‐A). Methods Patients bilateral or unilateral and normal controls underwent ‐A examination. Choriocapillaris s were quantitatively assessed on images matlab (version 2017b; MathWorks, Natick, MA, USA), after a preprocessing aimed at compensating for attenuation...