A5024056269- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Ophthalmology and Eye Disorders
- Ocular Surface and Contact Lens
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Cerebral Venous Sinus Thrombosis
- Retinal Development and Disorders
- Intraocular Surgery and Lenses
- Cerebrovascular and genetic disorders
- Neurological Disorders and Treatments
- Corneal Surgery and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Retinal and Macular Surgery
- Traumatic Ocular and Foreign Body Injuries
- Optical Coherence Tomography Applications
- Retinopathy of Prematurity Studies
- Pituitary Gland Disorders and Treatments
- Medical Imaging Techniques and Applications
- Moyamoya disease diagnosis and treatment
- Ocular Oncology and Treatments
- Cell Adhesion Molecules Research
- Microbial metabolism and enzyme function
- Ophthalmology and Visual Impairment Studies
University of Siena
2011-2020
Ospedale Santa Maria alle Scotte
2016-2020
Alcon (United States)
2015
Ophthalmology Associates (United States)
2010
University of Genoa
2009
Abstract Purpose To examine the circadian intraocular pressure ( IOP ) patterns in healthy subjects, primary open angle and normal tension glaucoma POAG ; NTG using a contact lens sensor CLS Sensimed Triggerfish, Lausanne, Switzerland). Methods This was an observational, nonrandomized study. Ten subjects (Group 1, 10 eyes) 20 glaucomatous patients [20 eyes, with 2) 3)] were enrolled. All controlled prostaglandin analogues. The 24‐hr pattern main outcome. morning (6 AM –11 ),...
In order to test the hypothesis that in primary open angle glaucoma (POAG), an important cause of irreversible blindness, a spreading neurodegeneration occurs through brain, we performed multimodal MRI and subsequent whole-brain explorative voxelwise analyses 13 advanced POAG patients 12 age-matched normal controls (NC). Altered integrity (decreased fractional anisotropy or increased diffusivities) white matter (WM) tracts was found not only along visual pathway but also nonvisual WM...
Abstract Our aim was to assess in primary open angle glaucoma (POAG), a major cause of irreversible blindness worldwide, whether diffuse brain changes recently shown advanced stage can be detected since the early stage. We used multimodal magnetic resonance imaging (MRI) 57 patients with three POAG stages and 29 age‐matched normal controls (NC). Voxelwise statistics performed nonparametric permutation testing. Compared NC, disrupted anatomical connectivity (AC) found whole group along visual...
To compare the reduction of intraocular pressure (IOP) and glaucoma medications following selective laser trabeculoplasty (SLT) versus stand-alone placement Hydrus microstent, a microinvasive surgery device.Prospective interventional case-series. University practice.Fifty six eyes (56 patients) with uncontrolled primary open-angle glaucoma.Patients received either SLT (n = 25) or implantation 31) in two centres. Patients were evaluated at baseline 1, 7 days, 3, 6 12 months after...
To evaluate frequency, conversion rate, and risk factors for blindness in glaucoma patients treated European Universities.This multicenter retrospective study included 2402 consecutive with at least one eye. Medical charts were inspected divided into those blind the remainder ('controls'). Blindness was defined as visual acuity≤0.05 and/or field loss to less than 10°.Unilateral bilateral respectively 11.0% 1.6% beginning, 15.5% 3.6% end of observation period (7.5±5.5 years, range:1-25...
Brain changes within and beyond the visual system have been demonstrated in primary open angle glaucoma (POAG), most common type of glaucoma. These often interpreted as a neurodegenerative process due, at least partially, to raised intraocular pressure (IOP). In this context, normal tension (NTG), form POAG with IOP <21 mm Hg despite typical glaucomatous findings, represents suitable model test validity hypothesis. We acquired multimodal brain MRI NTG patients (n = 17) compared them...
Although lysyl oxidase-like 1 (LOXL1) is known as the principal genetic risk factor for pseudoexfoliation (PEX) syndrome, a major cause of glaucoma and cardiovascular complications, no functional variants have been identified to date. Here, we conduct genome-wide association scan on 771 German PEX patients 1,350 controls, followed by independent testing associated in Italian Japanese data sets. We focus 3.5-kb four-component polymorphic locus positioned spanning introns 2 LOXL1 with...
The molecular events responsible for obstruction of aqueous humor outflow and the loss retinal ganglion cells in glaucoma, one main causes blindness worldwide, remain poorly understood. We identified a synonymous variant, c.765C>T (Thr255Thr), ankyrin repeats suppressor cytokine signaling box-containing protein 10 (ASB10) large family with primary open angle glaucoma (POAG) mapping to GLC1F locus. This variant affects an exon splice enhancer site alters mRNA splicing lymphoblasts affected...
This prospective study was conducted to evaluate the efficacy and safety of transscleral diode laser cyclophotocoagulation (TDLCP) in advanced refractory glaucoma.A total 124 eyes 121 patients with glaucoma medical treatment were treated consecutively TDLCP. Success defined as final intraocular pressure (IOP) 5-21 mmHg visual acuity (VA) more than hand movements (HM) relief pain VA HM or less, including blind eyes.Mean patient age 65.6 +/- 17.1 years (range 14-91 years). Mean follow-up 17...
<h3>Aim</h3> To investigate, using laser scanning confocal microscopy (LSCM), the morphological changes of meibomian glands (MGs) in patients with glaucoma. <h3>Methods</h3> A total 80 who were glaucomatous enrolled, and 20 healthy subjects used as controls. After completing an Ocular Surface Disease Index (OSDI) questionnaire, all underwent tear film break-up time (BUT), fluorescein staining, Schirmer test I (STI) LSCM examination MGs. The main outcome measures were: eyelid margin...
Purpose: To determine whether there were ocular surface changes in glaucomatous patients treated with preservatives beta-blockers who switched to preservative-free beta-blockers. Methods: This was a prospective, longitudinal, open-labeled study. One hundred thirty-two primary open angle glaucoma preserved beta-blocker enrolled. All the underwent perimetric and gonioscopic examination, complete ophthalmologic intraocular pressure (IOP) measurements, evaluation of surface, Schirmer's test,...
We analyzed the preoperative conjunctival goblet cell density (GCD), MUC5AC, and HLA-DR in glaucomatous patients undergoing trabeculectomy, using laser scanning confocal microscopy (LSCM) impression cytology (IC).We enrolled 57 trabeculectomy. At baseline LSCM IC were performed at site planned for surgery; was repeated after 12 months bleb site. The main outcomes were: GCD, mean microcyst (MMD) area (MMA) LSCM, positivity IC, IOP. relationships between 12-month IOP, MMD, MMA...
Abstract Purpose To evaluate the effects at 1 year of preservative‐free timolol gel and preserved eye drops on conjunctiva tear parameters. Methods Forty patients with primary open‐angle glaucoma or ocular hypertension were randomized to two treatment groups compared 20 healthy age‐matched controls. Clinical tests ( IOP , Schirmer I test, lacrimal film break‐up time BUT ) in vivo conjunctival confocal microscopy IVCM performed all baseline after 12 months. HRT II R ostock C ornea M odule; H...
As a progressive condition, glaucoma may impair health-related quality of life (HRQoL), due to vision loss and other factors. This study evaluated HRQoL in cohort patients treated for primary open-angle (POAG) assessed its association with clinical features.This was an Italian, multicentre, cross-sectional, observational the subgroup newly diagnosed POAG prospectively followed up one year. Patients previous or new diagnosis (or strong suspicion) aged >18 years were considered eligible....
Abstract LOXL1 (lysyl oxidase-like 1) has been identified as the major effect locus in pseudoexfoliation (PEX) syndrome, a fibrotic disorder of extracellular matrix and frequent cause chronic open-angle glaucoma. However, all known PEX-associated common variants show allele reversal populations different ancestry, casting doubt on their biological significance. Based extensive deep sequencing, we report here identification non-coding sequence variant, rs7173049A>G, located downstream...
<h3>Aim</h3> To evaluate the long-term perimetric fluctuation (LF) in patients with different stages of glaucoma according to Glaucoma Staging System 2 (GSS2). <h3>Methods</h3> This multicentre retrospective study included 161 eyes stable undergoing four visual-field tests (Humphrey SITA-Standard program over central 24° or 30°) a 2-year period. For each patient, stage disease was classified GSS2. LF then calculated as mean standard deviations point-to-point threshold sensitivities...
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is considered a genetic form of small-vessel disease causing dementia. A relevant role axonal injury was recently proposed to explain disability cognitive decline in this disease. The retinal nerve fiber layer (RNFL) the only part brain where unmyelinated axons can be visualized quantified vivo. Their assessment may an easily reproducible marker neurodegenerative processes. aim study...
Abstract Purpose To compare the diagnostic accuracy of minimum rim width ( MRW ), peripapillary retinal nerve fibre layer pRNFL ) and multilayered macular analysis by Spectralis SD ‐ OCT (Heidelberg Engineering, Germany) in discriminating perimetric glaucoma at different stages disease from healthy eyes. Methods In this multicentre, prospective, evaluation tests study, were obtained one eye 197 (76 early, 68 moderate 53 advanced) 83 controls Multicenter Italian Glaucoma Imaging Study MIGIS...
<b><i>Purpose:</i></b> To evaluate short-term intraocular pressure (IOP) changes after phacoemulsification in glaucoma and normal patients the effect of oral acetazolamide (Diamox) to control IOP these patients. <b><i>Methods:</i></b> 120 undergoing cataract surgery were included this prospective multicenter study involving 6 University Eye Clinics: 60 with well-controlled primary open-angle (POAG) controls. Half participants received...
Single nucleotide polymorphisms (SNPs) within the LOXL1 gene are associated with pseudoesfoliation syndrome and glaucoma. The aim of our study is to investigate a potential involvement in pathogenesis pigment dispersion (PDS) pigmentary glaucoma (PG).A cohort Caucasian origin 84 unrelated clinically well-characterised patients PDS/PG 200 control subjects were included study. Genomic DNA from whole blood was extracted coding regulatory regions risequenced both controls identify unknown...
To assess the involvement of WDR36 sequence variance in primary open-angle glaucoma (POAG) Italian patients.A cohort 34 families affected by POAG was analysed denaturing high-performance liquid chromatography for mutation gene. Among enrolled, 25 were high-tension (HTG), four juvenile and one normal tension glaucoma. In addition, presented both HTG-POAG patients within same pedigree.Four previously identified intronic polymorphisms (IVS5+30C→T; IVS12+90 G→T; IVS13+89G→A; IVS16-30A→G) a novel...