To evaluate the repeatability and reliability of a recently introduced swept-source Fourier-domain anterior segment optical coherence tomography (AS-OCT) system high-resolution Scheimpflug camera to assess agreement between 2 instruments when measuring healthy eyes with keratoconus.Department Ophthalmology, Medical Health Science Center, University Debrecen, Hungary.Evaluation diagnostic test or technology.Three consecutive series images were taken AS-OCT (Casia SS-1000) followed by rotating...

PURPOSE: To analyze the repeatability of a new device measuring ocular biomechanical properties, central corneal thickness (CCT), and intraocular pressure (IOP) to investigate these parameters their correlations in healthy eyes. METHODS: Three consecutive measurements were performed on each eye using CorVis ST (Oculus Optikgeräte, Inc., Wetzler, Germany). Ten specific parameters, CCT, IOP measured. Biometric data recorded with IOLMaster (Carl Zeiss Meditec, Jena, RESULTS: This study...

To evaluate tear osmolarity with the recently introduced TearLab system (TearLab Corporation, San Diego, CA) in patients non-Sjögren syndrome dry eye (NSSDE) and Sjögren (SSDE), healthy subjects, to compare results those from classical tests.Thirty-nine eyes of 21 NSSDE, 39 20 SSDE, 44 22 individuals were included study. Tear was measured system, lid-parallel conjunctival folds score examined slit lamp, then diagnostic tests such as Schirmer I test, film break-up time, corneal staining...

Purpose: The aim of this study was to quantify epithelial, stromal, and endothelial cell density, subbasal nerve morphology in young patients with type 1 diabetes mellitus without diabetic retinopathy. Methods: A total 28 (mean age, 22.86 ± 9.05 years) diabetes, (n = 18) 10) retinopathy, 17 age-matched healthy control subjects 26.53 2.43 underwent corneal confocal microscopy (CCM). Results: We found significantly lower epithelial (P < 0.0001) 0.001) densities higher keratocyte density 0.024)...

Uveal melanoma is the most common primary intraocular malignancy. A vast majority of metastasizing tumors have mutations in BAP1 gene. Here, we investigate spatiotemporal timing these mutations. The size 177 uveal melanomas and 8.3 million individual tumor cells was measured. sequencing results IHC were available for 76 (43%) 101 (57%) these, respectively. Tumors with a mutation had significantly larger volume (2109 vs. 1552 mm3, p = 0.025). Similarly, loss protein expression (2657 1593 μm3,...

Abstract To provide an artificial intelligence (AI) method using in vivo confocal microscopy (IVCM) to differentiate ocular surface squamous neoplasia (OSSN) from other lesions and compare the performance of well-known AI-related solutions. A dataset 2,774 IVCM images, comprising OSSN diseases was used train three deep learning models: ResNet50V2, Yolov8x, VGG19. These models were trained identify OSSN-related by recognizing specific visual features, including “starry-sky” pattern,...

The aim of the present study is to determine corneal physiology and endothelial morphology after proper image analysis technique in type I II diabetic patients. HbA1c level grade retinopathy were also recorded correlated with parameters.41 eyes 21 patients 59 30 diabetes mellitus (mean age was 40.97 ± 15.46 64.36 10.47 years) examined compared age-matched controls. Endothelial cell density (ECD), mean area, coefficient variation central thickness, intraocular pressure, recorded.There a...

To analyze the magnitude, orientation, and age-related changes of corneal astigmatism its correlation with biometric parameters in healthy eyes. Patients over 15 years age were enrolled our study. Exclusion criteria previous ocular surgery, disease, or contact lens wear. Axial length (AL), keratometric readings, anterior chamber depth (ACD) assessed using IOLMaster. In study, 1092 eyes examined. The mean was 69.64 ± 15.25 (range 15-100 years). AL 23.32 1.49 mm ACD 3.17 2.03 mm. Higher values...

To measure surgically induced astigmatism (SIA) on the posterior surface of cornea using Scheimpflug-based keratometry eyes with with-the-rule astigmatism.Repeated was obtained preoperatively and a mean 8.65 weeks postoperatively following superior clear corneal incisions. Differences in keratometric values SIA were determined anterior surfaces separately data analyzed.The study included 88 patients (age range: 46.4 to 87.5 years), steepest total meridian between 75° 105°. Preoperatively,...

Pellucid marginal degeneration (PMD) is an uncommon cause of inferior peripheral corneal thinning disorder, characterized by irregular astigmatism. We analyzed a case bilateral PMD patient and treated one eye with collagen cross-linking (CXL) therapy. Corneal topography was characteristic for PMD. Visual acuity, slitlamp examinations, tonometry, thickness were observed. Simulated keratometric topographic index values detected topography. Uncorrected, LogMAR visual acuity has improved from...

Purpose: Our aim was to assess the corneal power, axis, and age dependence of anterior posterior surfaces with Scheimpflug imaging. Methods: Patients older than 10 years without a history ocular surgery, diseases, contact lens wearing, or severe dry eye were enrolled. Data regarding cornea analyzed by means imaging (Pentacam HR). Results: The median 46.8 (range: 10.0–90.3), involved 827 eyes patients. Posterior astigmatism −0.30 diopters (D) exceeded 0.50 D in 12.56%. ratio...

Purposes: To assess the tear osmolarity using TearLab device after laser in situ keratomileusis (LASIK) and to compare values with those obtained by traditional film tests before procedure. Methods: Thirty eyes of 15 refractive surgery candidates (5 men 10 women mean age: 30.55 ± 11.79 years) were examined. Using a special questionnaire (Ocular Surface Disease Index), subjective dry eye complaints evaluated, then, was measured system (TearLab Corporation) conventional carried out....

It is necessary to understand the mechanisms of metastasis uveal melanoma advise patients and develop treatments for this tumor.To examine stochastic properties primary including mutation rate as a function tumor size metastatic relative type mutation.We computed in different sized melanomas using previously published large data sets. Tumor volume was estimated spherical cap method. We also calculated an updated set with known mutations BAP1, SF3B1, EIF1AX provided by Rotterdam Ocular...

To determine the reliability and repeatability of keratometry (K) measurements obtained with Pentacam high resolution (HR), automated keratometry, corneal topography systems.The right eyes 46 healthy subjects were examined prospectively. Keratometry in flat (Kf) steep (Ks) meridians taken by 2 independent investigators HR (Oculus, Wetzlar, Germany) followed keratorefractometry (KR-8100; Topcon, Tokyo, Japan), (TMS-4; Tomey, Erlangen, Germany).The mean K readings HR, 43.40/43.34 diopter (D),...

Purpose: To study the reliability and repeatability of anterior segment measurements in patients who underwent penetrating keratoplasty with swept light source Fourier domain optical coherence tomography (SS-OCT) comparison a high-resolution Scheimpflug camera. Methods: Keratometry (K) elevation data posterior corneal surfaces, central thickness, chamber depth were determined 56 postkeratoplasty eyes (mean age: 59.6 ± 16.5 yrs) SS-OCT (CASIA SS-1000; Tomey) followed by photography (Pentacam...

PURPOSE: To analyze the repeatability of keratometric and white-to-white (WTW) distance measurements with VERION Measurement Module (Alcon Laboratories, Inc., Fort Worth, TX) to compare measured data results IOLMaster (Carl Zeiss Meditec, Jena, Germany). METHODS: Three images were captured flattest steepest data, astigmatism axis, WTW recorded. Subsequently, axial length, an IOLMaster. The value System, converted cross cylinder J 0 45 vector components, analyzed. agreement for keratometry...

Purpose: We have previously used in vivo corneal confocal microscopy (IVCCM) to demonstrate significant alterations the epithelial cells, stromal keratocytes, and subbasal nerves young patients with type 1 diabetes mellitis (T1DM), especially those diabetic retinopathy (DR). evaluated change cellular nerve morphology over 2 years T1DM or without DR. Methods: A total of 19 T1DM, (n = 12) 7) DR age- sex-matched healthy control subjects underwent quantification plexus by using IVCCM at baseline...

To perform white-to-white (WTW) and angle-to-angle (ATA) distance measurements with 2 optical devices analyze the correlation other anterior segment parameters.Department of Ophthalmology, Medical Health Science Center, University Debrecen, Hungary.Comparative case series.In this prospective study, WTW distance, axial length (AL), chamber depth (ACD) were measured by partial coherence interferometry (PCI) (IOLMaster). The horizontal vertical ATA distances ACD assessed tomography (AS-OCT)...

Riboflavin UVA (collagen crosslinking [CXL]) treatment for keratoconus is a method stabilizing or improving corneal properties. Our aim was to evaluate changes in topography indices after CXL. A total of 38 eyes 25 patients (mean age 29.36 ± 9.7 years) were treated with CXL technique. The follow-up period 36 months. Slit-lamp examination, visual acuity tests, and pachymetry measurements performed; order obtain the following numerical data, (TMS-4; Tomey) used: simulated keratometry (K1, K2),...

The purpose of this study was to evaluate corneal cellular and ultrastructural changes quantify the neuroinflammatory process in patients after mild severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.Thirty SARS-CoV-2 infection 41 age-matched controls were examined. All subjects underwent vivo confocal microscopy cell layers subbasal nerve fibers with Heidelberg Retina Tomograph II. Semiautomated analysis basal epithelial, anterior posterior stromal keratocyte,...

To determine the difference between endothelial cell density (ECD) and morphologic measurements assessed with a recently developed noncontact specular microscope compared contact microscope. The agreement 2 independent operators was also investigated.The central corneal endothelium examined in right eyes of 41 healthy individuals using automated image analysis programs without correction for (EM-3000, EM-1000; Tomey, Tennenlohe, Germany). evaluated parameters such as ECD,average area (AVG),...

Purpose: To obtain the central corneal thickness (CCT) of healthy eyes using rotating Scheimpflug imaging system and compare these results with conventional ultrasound pachymetry values. Interoperator reliability repeatability different techniques were also determined. Methods: CCT was measured on right eye 46 subjects Pentacam HR (Pentacam High Resolution; Oculus, Wetzlar, Germany) contact (AL-2000; Tomey, Tennenlohe, by 2 independent investigators. Results: Both observers obtained...