A5072749330- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Cytomegalovirus and herpesvirus research
- Systemic Lupus Erythematosus Research
- Ocular Surface and Contact Lens
- Ocular Infections and Treatments
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Immune Cell Function and Interaction
- Retinal Diseases and Treatments
- Reproductive System and Pregnancy
- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Inflammasome and immune disorders
- Mosquito-borne diseases and control
- Bartonella species infections research
- Neurological Disorders and Treatments
- Ophthalmology and Eye Disorders
- Allergic Rhinitis and Sensitization
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Infectious Diseases and Tuberculosis
- SARS-CoV-2 and COVID-19 Research
- Vasculitis and related conditions
- Liver Diseases and Immunity
Singapore National Eye Center
2012-2024
Singapore Eye Research Institute
2012-2024
National University of Singapore
2016-2021
Duke-NUS Medical School
2019-2021
National Eye Institute
2019-2020
National Institutes of Health
2019-2020
Oregon Health & Science University
2018
Legacy Health
2018
Changi General Hospital
2008-2012
An international, expert-led consensus initiative to develop systematic, evidence-based recommendations for the treatment of noninfectious uveitis in era biologics.The availability biologic agents human eye disease has altered practice patterns management uveitis. Current guidelines are insufficient assure optimal use noncorticosteroid systemic immunomodulatory agents.An international expert steering committee comprising 9 specialists (including both ophthalmologists and rheumatologists)...
Inflammatory adverse events following COVID-19 vaccination are being reported amidst the growing concerns regarding vaccine's immunogenicity and safety, especially in patients with pre-existing inflammatory conditions.Multinational case series of diagnosed an ocular event within 14 days collected from 40 centres over a 3 month period 2021.Seventy presented vaccination. The mean age was 51 years (range, 19-84 years). most common were anterior uveitis (n = 41, 58.6%), followed by posterior 9,...
To describe the prevalence and associations of meibomian gland dysfunction (MGD) in an urban Malay population Singapore.Population-based cross-sectional study 3280 (78.7% response rate) persons aged 40 to 80 years, living Singapore. MGD was defined by a slit-lamp clinical examination as either lid margin telangiectasia or orifice plugging at least one eye. Participants underwent standardized questionnaire examination, including laboratory investigations. Data were analyzed for 3271...
To describe the pattern of uveitis among Chinese, Malays, and Indians at a tertiary referral institution in Singapore.Charts between January 1997 December 2010 were retrospectively reviewed. Charts 2014 prospectively reviewed.A total 1249 148 charts reviewed, respectively. The top causes anterior (AU) HLA-B27, idiopathic, CMV AU. known intermediate tuberculosis, primary intraocular lymphoma, sarcoidosis. posterior retinitis, toxoplasmosis, dengue maculopathy. panuveitis VKH, idiopathic...
Purpose: To describe the pattern of uveitis among Vietnamese at two eye hospitals in Southern Vietnam.Methods: We retrospectively reviewed charts 212 consecutive cases that presented to Ho Chi Minh City, Vietnam, from July 2011 February 2015. The patients were identified a database maintained by hospitals. Patients with keratitis, episcleritis, orbital inflammation, post-surgical endophthalmitis, traumatic iritis, and corneal graft rejection excluded. Data collected included demographic,...
To describe the pattern of uveitis at a tertiary referral clinic in Sri Lanka.Consecutive charts identified from registry between January 2010 and December 2014 Mediclinic Hospital, Colombo were retrospectively reviewed.Among 750 patients, anterior (AU) was most common (285, 38%), followed by posterior (187, 25%), intermediate (150, 20%), panuveitis (128, 17%). 485 (65%) idiopathic. The top causes AU seronegative-spondyloarthropathy-related-AU (37, 13%), HLA-B27-related-AU without systemic...
Cytomegalovirus (CMV) anterior uveitis and endotheliitis occurs among immunocompetent individuals may manifest as Posner–Schlossman syndrome or Fuchs syndrome. The condition first present following ophthalmic surgery, the use of a fluocinolone-sustained steroid drug delivery implant, topical prostaglandin analogues for treatment glaucoma. We report case non-human immunodeficiency virus-infected individual who presented with CMV after cyclosporine A 0.05% emulsion symptomatic dry eyes.
To compare the angle and intraocular pressure (IOP) changes after phacoemulsification between eyes with closed-angle or open-angle glaucoma.Angle measurements using Visante AS-OCT imaging was performed for a prospective cohort of 24 subjects 30 glaucoma before 3 months phacoemulsification. IOP measurement measured at 6 12 surgery Goldmann applanation tonometry as secondary outcome measures.Eyes closed angles were smaller than those open (mean axial length 22.88 vs. 24.11 mm, P<0.001). Mean...
Purpose: To evaluate the prognostic value of OCT in acute VKH diseaseMethods: Retrospective series consecutive patients seen with first presentation, a minimum follow-up 1 year and serial imaging. The primary outcome was clinical activity phase at 1, 2 3 years.Results: Among 29 subjects, 7 resolved, 17 became chronic, 5 developed chronic recurrent VKH. Median RNFL measurement obtained months post-treatment higher among subjects who (p-value = 0.03) disease 0.04). CRT 1-week lower PPA 0.03)....
Objective A prospective clinical study to assess the utility of CD4 + T cell lymphocyte profiling from peripheral blood in patients with ocular tuberculosis (TB).Methods Thirty-six Asian presumed diagnosis TB were recruited for T-lymphocyte profiling. MTB antigen specific assay was set up, and flow cytometric data analyzed using FlowJo software.Results There no significant difference between treatment responders non-responders proportion cells PPD or ESAT-6+ CFP-10, but did have...
Cytomegalovirus (CMV) causes clinical issues primarily in immune-suppressed conditions. CMV-associated anterior uveitis (CMV-AU) is a notable new disease entity manifesting recurrent ocular inflammation immunocompetent individuals. As patient demographics indicated contributions from genetic background and immunosenescence as possible underlying pathological mechanisms, we analyzed the immunogenetics of cohort conjunction with cell phenotypes to identify molecular signatures CMV-AU. Among...
Endothelial keratoplasty (EK) is less invasive with faster recovery as compared to conventional penetrating keratoplasty, however, it relies on the clarity of host corneal stroma. Corneal transplantation involves induction immune tolerance for allogeneic tissues well wound healing process, in which coordinated interactions between cytokines and growth factors are critical. In this study, we profiled expression 51 soluble tear fluid over course EK have provided evidence dynamic changes...
Ocular inflammatory conditions can be challenging to manage due their prolonged and complicated nature. While the mainstay treatment for most cases is oral or topical corticosteroids, it very important that physicians know how other medications such as biologic response modifiers (biologics) could used in certain cases. Through illustrative cases, we discuss with biologics helpful management of three patients ocular conditions. We review discuss, (1) a 60-year-old male granulomatosis...