A5106715625- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Ophthalmology and Visual Impairment Studies
- Allergic Rhinitis and Sensitization
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Ocular Infections and Treatments
- Olfactory and Sensory Function Studies
- Blood properties and coagulation
- Advancements in Transdermal Drug Delivery
- Retinal and Optic Conditions
- Salivary Gland Disorders and Functions
- Advanced Drug Delivery Systems
- Dermatology and Skin Diseases
- Advanced Glycation End Products research
- Skin Protection and Aging
- NF-κB Signaling Pathways
- Ocular Diseases and Behçet’s Syndrome
- Proteoglycans and glycosaminoglycans research
- Intraocular Surgery and Lenses
- Wound Healing and Treatments
- Immune Response and Inflammation
- Urticaria and Related Conditions
National University of Singapore
2016-2025
Singapore National Eye Center
2016-2025
Singapore Eye Research Institute
2016-2025
Nanjing University of Science and Technology
2024-2025
Duke-NUS Medical School
2015-2024
Nanyang Technological University
2024
University of Nottingham
2000-2023
Queen's Medical Centre
2001-2023
Narayana Nethralaya
2023
Creative Commons
2023
<h3>Aim:</h3> To investigate the relationship of outdoor activities and myopia in Singapore teenage children. <h3>Methods:</h3> Teenage children (1249 participants), examined Cohort study Of Risk factors for Myopia (SCORM), during 2006 were included analyses. Participants completed questionnaires that quantified total activity, underwent an eye examination. <h3>Results:</h3> The mean time spent on activity was 3.24 h/day. (h/day) significantly associated with myopia, odds ratio 0.90 (95% CI...
To determine the incidence and progression rates of myopia in young Singaporean children.A prospective cohort study, Singapore Cohort Study Risk Factors for Myopia (SCORM), was conducted two schools (1999-2002). Children aged 7 to 9 years (n=981) were followed up over a 3-year period. Cycloplegic autorefraction biometry parameter measures performed annually, according same protocol.The cumulative 47.7% (95% confidence interval [CI]: 42.2-53.3), 38.4% CI: 31.4-45.4), 32.4% 21.8-43.1) 7-, 8-,...
The proteins found in tears have an important role the maintenance of ocular surface and changes quality quantity tear components reflect health surface. In this study, we used quantitative proteomics, iTRAQ technology coupled with 2D-nanoLC-nano-ESI-MS/MS a statistical model to uncover that are significantly reliably changed dry eye patients effort reveal potential biomarker candidates. Fifty-six 40 healthy subjects were recruited for study. total, 93 identified ProtScore ≥2 (≥99%...
The tear film covers the anterior eye and precise balance of its various constituting components is critical for maintaining ocular health. composition amphiphilic lipid sublayer, in particular, has largely remained a matter contention due to limiting concentrations these amphiphiles tears that render their detection accurate quantitation tedious. Using systematic sensitive lipidomic approaches, we validated different collection techniques report most comprehensive human lipidome date;...
Epilepsy is a global disease with considerable incidence due to recurrent unprovoked seizures. These seizures can be noninvasively diagnosed using electroencephalogram (EEG), measure of neuronal electrical activity in brain recorded along scalp. EEG highly nonlinear, nonstationary and non-Gaussian nature. Nonlinear adaptive models such as empirical mode decomposition (EMD) provide intuitive understanding information present these signals. In this study novel methodology proposed...
Background Previous lipidomic analyses of the human meibum had largely focused on individuals from non-Asian populations, despite higher prevalence dysfunctional tear syndrome (DTS) observed across Asia. Information pertaining to alterations in lipid profiles relation DTS onset and progression is also lacking warrants comprehensive experimental analysis. Methodologies/Principal Findings We examined lipidome 27 patients 10 control subjects for a total 256 species 12 major classes, including...
Intrinsic time-scale decomposition (ITD) is a new nonlinear method of time-frequency representation which can decipher the minute changes in EEG signals. In this work, we have automatically classified normal, interictal and ictal signals using features derived from ITD representation. The energy, fractal dimension sample entropy computed on coupled with decision tree classifier has yielded an average classification accuracy 95.67%, sensitivity specificity 99% 99.5%, respectively 10-fold...
Background/aims To identify the risk factors for neuropathic corneal pain (NCP) following refractive surgery and to report its clinical manifestations, imaging proteomic characteristics. Methods This 1 year prospective cohort study included 100 eyes that underwent small incision lenticule extraction (SMILE) or laser-assisted in situ keratomileusis (LASIK). Ocular surface assessments, in-vivo confocal microscopy scans, tear neuromediators proteomics analyses were performed. NCP was assessed...