Background/aims To identify the risk factors for neuropathic corneal pain (NCP) following refractive surgery and to report its clinical manifestations, imaging proteomic characteristics. Methods This 1 year prospective cohort study included 100 eyes that underwent small incision lenticule extraction (SMILE) or laser-assisted in situ keratomileusis (LASIK). Ocular surface assessments, in-vivo confocal microscopy scans, tear neuromediators proteomics analyses were performed. NCP was assessed...

To investigate the tear proteomic and neuromediator profiles, in vivo confocal microscopy (IVCM) imaging features, clinical manifestations neuropathic corneal pain (NCP) patients.

Purpose: To investigate the aqueous proteomics and metabolomics in low-energy high-energy femtosecond laser-assisted cataract surgery (FLACS). Methods: In this prospective observational study, 72 patients were randomized to 3 groups: FLACS, conventional phacoemulsification (controls). Aqueous was collected after laser treatment or at beginning of Proteomic analysis conducted using a data-independent acquisition method, whereas analyzed with liquid chromatography-tandem mass spectrometry....

The Ocular Pain Assessment Survey (OPAS) has been used to quantify chronic ocular pain and quality of life (QOL). We aim investigate the psychometric properties individual OPAS items with Rasch analysis in an Asian population dry eye disease neuropathic corneal (NCP). Question responses were obtained from 196 patients; 138 (DED) 58 NCP, at Singapore National Eye Centre. Item hierarchy, item fit statistics, separation, reliability indices, Yen's Q3 values calculated. Individual dimensions...

To evaluate the effects of smoking on ocular surface through comprehensive analysis corneal nerves, epithelium, dendritic cells (DCs), and clinical assessments. This cross-sectional study included 250 healthy smokers 272 non-smokers. Patients' status duration were recorded. In vivo confocal microscopy was performed to assess 7 quantitative nerves parameters, 3 neuroma DCs epithelial parameters. Ocular evaluations tear break-up time (TBUT), staining, sensitivity, Schirmer test. Surface...

Abstract Background To investigate and compare the corneal denervation, tear neuromediators, ocular surface changes following lenticule extraction for advanced refractive correction (CLEAR) versus small incision (SMILE). Methods In this randomized clinical trial, 19 patients were to undergo CLEAR in one eye SMILE other eye. Ocular assessments, vivo confocal microscopy seven nerve parameters, four dendritic cell three epithelial neuromediator analysis performed preoperatively 1, 3, 6 12...

Abstract Background To investigate the relationship between obesity and corneal nerve metrics in patients with type 2 diabetes mellitus (DM). Methods This cross-sectional study included a total of 385 healthy controls 663 DM. Metrics for epithelial cells were evaluated using in-vivo confocal microscopy (IVCM). Corneal cell parameters quantified compared without across six different body mass index (BMI) categories. Multivariable regression analyses conducted to determine association BMI...

Purpose: The aim of this study was to investigate age-related changes in corneal nerves and epithelial cell parameters establish age-adjusted reference values. Methods: A total 7025 nerve images 4215 obtained using vivo confocal microscopy from 281 eyes 143 healthy participants were included. Seven 3 quantified 2 automatic analytic software analyzed across 6 age groups ranging 21 80 years. Results: There a declining trend all 7 with advancing age. In particular, fiber length density...

A novel nanoscale-dispersed eye ointment (NDEO) for the treatment of severe evaporative dry has been successfully developed. The excipients used as semisolid lipids were petrolatum and lanolin, in conventional ointment, which coupled with medium-chain triglycerides (MCT) a liquid lipid; both phases then dispersed polyvinyl pyrrolidone solution to form nanodispersion. Single-factor experiments conducted optimize formulations. transmission electron micrograph showed that matrix was entrapped...

Objective To elucidate the relationship between lipid layer thickness (LLT), incomplete blinking rate and tear film stability in patients with different myopia degrees after small-incision lenticule extraction (SMILE) to determine whether there is a difference prevalence of dry eye disease (DED) SMILE among degrees. Methods Fifty (100 eyes) were enrolled this study; they divided into 3 groups according degree spherical refraction: low-myopia group (LMG; refraction ≤-3.00 D, 20 eyes),...

Purpose: To investigate and compare the quality of life (QoL) symptomatology between neuropathic corneal pain (NCP) dry eye disease (DED). Methods: We recruited 150 patients, comprising 50 patients with NCP 100 DED. Patients’ symptoms QoL were evaluated using Ocular Pain Assessment Survey Surface Disease Index questionnaires. surface assessments also performed. Results: Patients demonstrated significantly lower Oxford National Eye Institute scores for ocular staining, respectively, a better...

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes mellitus. refers to progressive damage nerves. has traditionally been considered as retinal microvasculature. However, growing evidence suggests that is a complex neurovascular disorder resulting from dysfunction unit, which includes both vascular structures neural tissues. one leading causes blindness frequently screened for part screening. commonly overlooked underdiagnosed,...

To evaluate the impact of corrected refractive power on corneal denervation and ocular surface in small-incision lenticule extraction (SMILE) laser situ keratomileusis (LASIK).Singapore National Eye Center, Singapore.Prospective study.88 eyes undergoing SMILE or LASIK were divided into low-moderate (manifest spherical equivalent [MRSE] <-6.0 diopters [D]) high myopic (MRSE ≥-6.0 D) groups. In vivo confocal microscopy clinical assessments performed preoperatively at 1 month, 3 months, 6 12...

Introduction: This is a case report of patient with neuropathic corneal pain after coronavirus disease 2019 (COVID-19) infection. Methods: A previously healthy 27-year-old female presented bilateral eye accompanied by increased light sensitivity 5 months COVID-19 She was diagnosed based on clear corneas without fluorescein staining, alongside the presence microneuromas, dendritic cells, and activated stromal keratocytes identified bilaterally in vivo confocal microscopy. Results: The...

Objectively compare the changes in ocular surface parameters myopic patients who have undergone either SMILE or Implantable Collamer Lens (ICL V4c) surgery. This prospective cohort study enrolled 32 (32 eyes) undergoing surgery and 35 (35 receiving ICL V4c intraocular lenses. Examinations were performed at preoperative, 1-week, 1-month, 3-month postoperative time points. The assessments included Schirmer's I Test (SIt), First Non-Invasive Break-Up Time (First-NIBUT), Average (Average-NIBUT),...

Purpose: To analyze the clinical and regional distribution characteristics of obstructive meibomian gland dysfunction (OMGD) in China. Methods: A total 2900 patients (2900 eyes) diagnosed with OMGD were enrolled this multicenter, cross-sectional, observational study. The Ocular Surface Disease Index (OSDI), tear film breakup time (FBUT), Schirmer test (SI), lipid layer thickness (LLT), grade, loss score (Meiboscore), meibum expressibility (MES), quality (MQS), Lid margin abnormality...

The aim of this study was to explore the correlation between intraoperative hyperalgesia second eye and dynamic changes tumor necrosis factor (TNF)-α interleukin (IL)-1β levels in aqueous humor (AH) whole blood after first cataract surgery. A rabbit model monocular phacoemulsification established by administration 0.3% levofloxacin. Whole AH samples from non-surgical eyes experimental group (n =25) blank control =15) were obtained corneal sensitivity examined surgery (1, 3, 7, 14, 21 days...

Purpose: To evaluate the relationship between structural and functional changes of corneal subbasal nerves after single-step transepithelial photorefractive keratectomy (TransPRK). Setting: Tianjin Medical University Eye Hospital. Design: Prospective observational study. Methods: 51 eligible candidates who underwent TransPRK for moderate myopia were included. The regeneration evaluated by in vivo confocal microscopy (IVCM) prior to surgery at 1 week month, 3 months, 6 12 months...