A5047285347- Ocular Diseases and Behçet’s Syndrome
- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- Retinal and Optic Conditions
- Ocular Surface and Contact Lens
- Herpesvirus Infections and Treatments
- Retinal Diseases and Treatments
- Ocular Infections and Treatments
- Glaucoma and retinal disorders
- Cytomegalovirus and herpesvirus research
- Vasculitis and related conditions
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Intraocular Surgery and Lenses
- Otitis Media and Relapsing Polychondritis
- Immune Response and Inflammation
- interferon and immune responses
- Inflammasome and immune disorders
- Spondyloarthritis Studies and Treatments
- Nephrotoxicity and Medicinal Plants
- Rheumatoid Arthritis Research and Therapies
- Sarcoidosis and Beryllium Toxicity Research
- Renal Diseases and Glomerulopathies
- Immunotherapy and Immune Responses
- Retinal and Macular Surgery
St. Franziskus Hospital
2016-2025
University of Duisburg-Essen
2016-2025
Essen University Hospital
1993-2018
Ophthalmology Associates (United States)
2016
Hospital zum Heiligen Geist
2015
German Rheumatism Research Centre
2015
Uniwersytecki Szpital Dziecięcy
2015
Children's Clinical University Hospital
2015
University Hospital Münster
2014-2015
Pfizer (United Kingdom)
2015
Patients with noninfectious uveitis are at risk for long-term complications of uncontrolled inflammation, as well the adverse effects glucocorticoid therapy. We conducted a trial to assess efficacy and safety adalimumab glucocorticoid-sparing agent treatment uveitis.This multinational phase 3 involved adults who had active intermediate uveitis, posterior or panuveitis despite having received prednisone 2 more weeks. Investigators patients were unaware study-group assignments. randomly...
Objectives. To analyse the prevalence and complications of uveitis their predictors in a large cohort patients with juvenile idiopathic arthritis (JIA).
An international, expert-led consensus initiative to develop systematic, evidence-based recommendations for the treatment of noninfectious uveitis in era biologics.The availability biologic agents human eye disease has altered practice patterns management uveitis. Current guidelines are insufficient assure optimal use noncorticosteroid systemic immunomodulatory agents.An international expert steering committee comprising 9 specialists (including both ophthalmologists and rheumatologists)...
In 2012, a European initiative called Single Hub and Access point for pediatric Rheumatology in Europe (SHARE) was launched to optimise disseminate diagnostic management regimens children young adults with rheumatic diseases. Juvenile idiopathic arthritis (JIA) is the most common disease uveitis possibly its devastating extra-articular manifestation. Evidence-based guidelines are sparse mostly based on physicians' experience. Consequently, treatment practices differ widely, within between...
Objective. Rituximab (RTX), a chimeric mAb directed against the B-cell marker CD20, was investigated for its anti-inflammatory effect in treating refractory uveitis associated with JIA. Methods. Case series, retrospective multicentre. JIA patients severe vision-threatening complications (n = 10) and insidious onset. All were treated RTX active to topical systemic CSs, immunosuppressives at least one of TNF-α inhibitors. had arthritis. Uveitis arthritis course assessed before after treatment....
Ocular chronic graft-versus-host disease (cGVHD) is one of the most frequent long-term complications after hematopoietic stem cell transplantation and often associated with significant morbidity reduced quality life.The German/Austrian/Swiss Consensus Conference on Clinical Practice in cGVHD aimed to summarize currently available evidence for diagnosis (topical) treatment different modalities ocular cGVHD. The presented consensus was based a review published survey current clinical practice...
The objective was to evaluate the 25(OH) vitamin D (25(OH)D) status of patients with juvenile idiopathic arthritis (JIA) and determine whether 25(OH)D level is associated disease activity course JIA. Patients ≤ 16 years age recently diagnosed JIA (< 12 months) were enrolled in inception cohort newly (ICON), an ongoing prospective observational, controlled multicenter study started 2010. Clinical laboratory parameters ascertained quarterly during first year half-yearly thereafter. Of 954...
Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children and adolescents. Immunomodulatory drugs are used frequently its treatment. Using nominal group technique (NGT) Delphi method, we created a multidisciplinary, evidence- consensus-based treatment guideline for JIA based on systematic literature analysis three consensus conferences. Conferences were headed by professional moderator attended representatives who had been nominated their scientific societies or...
To report on experience using the anti-interleukin 6 receptor antibody tocilizumab (TCZ) to treat severe and therapy-refractory uveitis associated with juvenile idiopathic arthritis (JIA).Retrospective data were gathered from patients JIA receiving TCZ treatment for uveitis. related (disease onset, activity, structural complications, topical systemic antiinflammatory treatment) evaluated at start of (baseline) every 3 months during therapy.A total 17 (14 women) active included (mean age 15.3...
Objective. Abatacept (ABA), a selective T cell costimulation modulator that binds to CD80 and CD86 on antigen-presenting cells, was investigated for its antiinflammatory effect in treating severe chronic uveitis associated with juvenile idiopathic arthritis (JIA). Methods. Our retrospective study conducted by members of the Multinational Interdisciplinary Working Group Uveitis Childhood (MIWGUC). Patients JIA who are receiving ABA treatment active were included. In all patients, had been...
Microglia represent the primary resident immune cells of central nervous system (CNS) and modulate local responses. Depending on their physiological functions, microglia can be classified into pro- (M1) anti-inflammatory (M2) phenotype. Interleukin (IL)-10 is an important modulator neuronal homeostasis, with neuroprotective released by microglia. Here, we investigated how IL-10 deficiency affected M1/2 polarization upon lipopolysaccharide (LPS) stimulation in vitro. phenotypes were analyzed...
We evaluated the relationship between ocular surface damage, elevated lid aperture/impaired Bell's phenomenon and reduced tear production in thyroid-associated ophthalmopathy (TAO). Suspecting a possible role of autoantibodies specific for TSH receptor (TSHR), we further investigated TSHR expression healthy lacrimal gland (LG).A total 48 patients with active TAO 26 controls were examined basal secretion, Rose Bengal fluorescein staining, impression cytology (IPC), break-up time (BUT),...
To study the value of methotrexate (MTX) and requirement for additional anti-inflammatory drugs treatment severe chronic iridocyclitis associated with juvenile idiopathic arthritis (JIA).Institutional 35 consecutive patients JIA started on MTX as single systemic immunosuppressive drug iridocyclitis. The clinical epidemiologic data, course visual acuity (VA), development complications, need were analyzed.Mean follow-up was 27.6 months. Uveitic complications present in 31 before treatment....
In Brief Purpose: Bevacizumab is a monoclonal antibody to vascular endothelial growth factor (VEGF) which has been successfully used for the treatment of age-related macular degeneration with choroidal neovascularization. As VEGF involved in pathomechanisms inflammation and dysfunction authors bevacizumab as last resort patients persistent uveitic cystoid edema (CME). Patients Methods: Persistent CME was defined by optical coherence tomography (OCT) measurements >250 μm despite previous...
Our purpose was to detect the rate of initial manifestation sarcoidosis in eye.We conducted a retrospective chart review clinic Germany. Ophthalmological data were obtained by using standardized protocol, including medical history, any comorbidity, onset and type ocular that evaluated slit lamp, tonometry fundoscopy.In cohort 1,800 patients (mean age 38.1 ± 11.8 years), diagnosis established most commonly bilateral hilar lymphadenopathy (96.2%), histopathology (46.9%) or other organ...
To describe the disease characteristics of patients with juvenile idiopathic arthritis (JIA) included in an inception cohort, to analyse how many from each JIA category reach inactive state within first year specialised care and determine predictors for attaining disease.Patients were enrolled this study at 11 large German paediatric rheumatology units 12 months after diagnosis. Laboratory clinical parameters such as core criteria data on medication used collected every 3 months....
<h3>Objective</h3> The aim of this study was to assess the efficacy adalimumab in patients with active non-infectious uveitis three different centres. <h3>Methods</h3> In a retrospective we identified from our databases who were treated adalimumab. composite outcome measure for included reduction macular oedema by optic coherence tomography, visual acuity, anterior chamber cells, frequency flares and prednisone dose during treatment. At least one criteria had be improved none worsened...