A5061459201- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Retinal Diseases and Treatments
- Autoimmune and Inflammatory Disorders Research
- Cytomegalovirus and herpesvirus research
- Cerebral Venous Sinus Thrombosis
- Drug-Induced Ocular Toxicity
- Ocular Infections and Treatments
- Psoriasis: Treatment and Pathogenesis
- Herpesvirus Infections and Treatments
- Inflammasome and immune disorders
- Toxoplasma gondii Research Studies
- Glaucoma and retinal disorders
- Otitis Media and Relapsing Polychondritis
- Fungal Infections and Studies
- NF-κB Signaling Pathways
- Developmental and Educational Neuropsychology
- Ocular Oncology and Treatments
- Bladder and Urothelial Cancer Treatments
- Cancer Treatment and Pharmacology
- Optical Coherence Tomography Applications
- Colorectal Cancer Treatments and Studies
- Sarcoidosis and Beryllium Toxicity Research
Hospital Clínic de Barcelona
2009-2019
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2011-2019
Universitat de Barcelona
2011-2016
Institute of Ophthalmology
2016
Fundació Clínic per a la Recerca Biomèdica
2016
Instituto de Investigación Marqués de Valdecilla
2014
Hospital de León
2014
Sabin Vaccine Institute
2014
Hospital Universitario Fundación Alcorcón
2014
To assess the efficacy of tocilizumab (TCZ) for treatment juvenile idiopathic arthritis (JIA)-associated uveitis.We conducted a multicenter study patients with JIA-associated uveitis that was refractory to conventional immunosuppressive drugs and anti-tumor necrosis factor (anti-TNF) agents.We assessed 25 (21 female; 47 affected eyes) mean ± SD age 18.5 8.3 years. Uveitis bilateral in 22 patients. Cystoid macular edema present 9 Ocular sequelae found at initiation TCZ included cataracts (n =...
To report the anatomical pattern and etiological spectrum of uveitis in an urban multi-ethnic population from Barcelona, Spain. General specific epidemiological data for most prevalent aetiologies are also calculated.A cross-sectional study consecutive cases was performed between 1 January 2009 31 December 2012. Exogenous endophthalmitis, surgery-related, post-traumatic toxic along with masquerade syndromes were excluded. Anatomical (Standard Uveitis Nomenclature criteria) aetiological...
Objective. The aim of this study was to assess the efficacy anti-TNF-α therapy in refractory uveitis due Behçet's disease (BD). Methods. We performed a multicentre 124 patients with BD conventional treatment including high-dose corticosteroids and at least one standard immunosuppressive agent. Patients were treated for 12 months infliximab (IFX) (3–5 mg/kg 0, 2 6 weeks then every 4–8 weeks) or adalimumab (ADA) (usually 40 mg weeks). main outcome measures degree anterior posterior chamber...
To report on experience using the anti-interleukin 6 receptor antibody tocilizumab (TCZ) to treat severe and therapy-refractory uveitis associated with juvenile idiopathic arthritis (JIA).Retrospective data were gathered from patients JIA receiving TCZ treatment for uveitis. related (disease onset, activity, structural complications, topical systemic antiinflammatory treatment) evaluated at start of (baseline) every 3 months during therapy.A total 17 (14 women) active included (mean age 15.3...
Objective. To describe the experience of two tertiary Spanish centres (Hospital Clínico San Cecilio, Granada and Hospital Clínic, Barcelona) with use adalimumab for treatment severe clinical manifestations in patients Behçet's disease (BD) whom immunosuppressive therapy had failed.
To evaluate the safety and efficacy of Ozurdex (dexamethasone intravitreal implant) 0.7 mg in treatment uveitic macular edema vitrectomized eyes.Data from 13 patients (17 eyes) with persistent cystoid a history pars plana vitrectomy study eyes that were treated injection 0.7-mg dexamethasone implant reviewed retrospectively. Main outcome measures changes central retinal thickness measured by optical coherence tomography best-corrected visual acuity.The median age was 61 years (range, 19-81...
Over the past decade, off-label use of biologic agents such as TNF-α antagonists, including infliximab and adalimumab, has improved treatment armamentarium for refractory immune-mediated uveitis, with particular success in Behçet disease-associated uveitis. Golimumab is a novel fully human anti-TNF-α monoclonal antibody that been approved rheumatoid arthritis, psoriatic ankylosing spondylitis, very promising results. Herein, authors present GLM case uveitis to other blockers. There are only...
Retinal vasculitis (RV) is an important component of Behçet disease. It may be difficult to detect either clinically or with conventional retinal imaging. The role ultra-wide-field (UWF) imaging was assessed in the diagnosis and management RV associated disease.A total 38 eyes 20 patients active disease underwent UWF Optos scanning laser ophthalmoscope, fundus autofluorescence, and/or fluorescein angiography. This study determined findings percentage whom this modality assisted diagnosing...
Objective . To evaluate, in three Spanish tertiary referral centres, the short-term safety and efficacy of golimumab (GLM) for treatment immune-mediated uveitis resistant to previous immunosuppressive therapy. Methods Nonrandomized retrospective interventional case series. Thirteen patients with different types that were at least 2 immunosuppressors included this study. All treated GLM (50 mg every four weeks) during 6 months. Clinical evaluation treatment-related side effects assessed times...
Purpose: To study the efficacy and tolerance of certolizumab pegol (CZP) in active uveitis.Methods: Retrospective case series at 4 referral centers. Patients treated with CZP for uveitis during least 6 months were eligible. Inflammation by SUN scores, visual acuity (VA) (logMAR), central macular thickness (CMT) compared from baseline until final follow-up. Quiescence was defined as 0+ to 0.5+ anterior chamber vitreous haze scores no CMT increase.Results: Four males 3 females (14 eyes)...
The aim of the present study was to determine serum cytokine profile and levels high sensitivity C-reactive protein (hsCRP) in patients with uveitis associated Behçet’s disease (BD) compare them those obtained from healthy control subjects. We determined concentration interferon-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>γ</mml:mi></mml:mrow></mml:math>(IFN-<mml:math id="M2"><mml:mrow><mml:mi>γ</mml:mi></mml:mrow></mml:math>), interleukin-1<mml:math...
To evaluate clinical and paraclinical parameters for the indirect diagnosis of tuberculosis-related uveitis (TRU).Prospective 2-year study in a tertiary referral centre. Patients with clinically suspected TRU were recruited. Demographical data recorded. QuantiFERON(®) -TB Gold (QFT), tuberculosis skin test (TST) pulmonary X-ray performed, other possible aetiologies ruled out. Further investigations also performed case by after consultation. After final assessment, standard antituberculosis...
The retinal pigment epithelium (RPE) forms the outer blood-retinal barrier (oBRB) and is prime target of early age-related macular degeneration (AMD). C-reactive protein (CRP), a serum biomarker for chronic inflammation AMD, presents two different isoforms, monomeric (mCRP) pentameric (pCRP), that may have effect on function in RPE. results reported this study suggest mCRP but not pCRP impairs RPE functionality by increasing paracellular permeability disrupting tight junction proteins ZO-1...
Abstract Purpose To evaluate serum cytokine profile from patients with active scleritis in a two‐centre prospective case–control study. Methods The of 20 not treated any local, periocular, or systemic immunomodulatory therapy ( IMT ) was analysed multiplex assay to determine the levels 11 cytokines interleukin IL )‐1 β , ‐6, ‐2, IFN ‐ γ ‐10, ‐12p40, ‐13, ‐17A, ‐5, TNF α and ELISA TGF 1, ‐22, ‐23. Twenty‐five age‐matched healthy volunteers were used as controls. In subgroup 13 disease, second...
We report the case of a 52-year-old woman with advanced colorectal cancer who was treated oxaliplatin on FOLFOX schedule. After 3 cycles chemotherapy, she started to complain visual loss, altered color vision and neurological symptoms. Due suspicion ocular toxicity, antineoplastic treatment stopped. Her field showed concentric bilateral scotoma electrooculogram test revealed severe impairment retinal pigment epithelium. Visual acuity, recovered completely 8 months later, although remained...