A5032206338- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Ocular Oncology and Treatments
- Corneal surgery and disorders
- Ocular Infections and Treatments
- Lymphoma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Cellular Mechanics and Interactions
- Immunotherapy and Immune Responses
- Autoimmune Bullous Skin Diseases
- Legionella and Acanthamoeba research
- Laser Applications in Dentistry and Medicine
- Chronic Lymphocytic Leukemia Research
- Peptidase Inhibition and Analysis
- Tendon Structure and Treatment
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Urticaria and Related Conditions
- Cardiac Structural Anomalies and Repair
- Ocular Diseases and Behçet’s Syndrome
- Wound Healing and Treatments
- Dermatologic Treatments and Research
- Cancer and Skin Lesions
Universitätsklinikum Würzburg
2004-2022
University of Würzburg
2006-2016
Augenklinik Universitätsklinikum Würzburg
2004-2016
University Hospitals of the Ruhr-University of Bochum
2014-2015
Düsseldorf University Hospital
2014-2015
Heinrich Heine University Düsseldorf
2014-2015
Universitätsaugenklinik Magdeburg
2015
Christie's
2014
Ophthalmology Clinic
2008
Ophthalmology Associates (United States)
2006
<i>Helicobacter pylori</i> is an etiological agent in the development of mucosa-associated lymphoid tissue lymphoma and gastric adenocarcinoma. Patients infected with <i>H. carry a 3–6-fold increased risk developing cancer compared uninfected individuals. strains expressing cytotoxin-associated antigen A (CagA) are more frequently associated neoplasia than cagA-negative strains. However, molecular mechanism by which<i>H. causes neoplastic transformation remains unclear. Here we report that...
Ocular chronic graft-versus-host disease (cGVHD) is one of the most frequent long-term complications after hematopoietic stem cell transplantation and often associated with significant morbidity reduced quality life.The German/Austrian/Swiss Consensus Conference on Clinical Practice in cGVHD aimed to summarize currently available evidence for diagnosis (topical) treatment different modalities ocular cGVHD. The presented consensus was based a review published survey current clinical practice...
<h3>Importance</h3> Giant cell arteritis (GCA) is the most common systemic vasculitis in elderly individuals. Diagnosis confirmed by temporal artery (TA) biopsy, although biopsy results are often negative. Despite use of corticosteroids, disease may progress. Identification causal agents will improve outcomes. Biopsy-positive GCA associated with TA infection varicella-zoster virus (VZV). <h3>Objective</h3> To analyze VZV TAs patients clinically suspected whose were histopathologically...
Eye drops of aganirsen, an antisense oligonucleotide preventing insulin receptor substrate-1 expression, inhibited corneal neovascularization in a previous dose-finding phase II study. We aimed to confirm these results III study and investigated potential clinical benefit on visual acuity (VA), quality life (QoL), need for transplantation.Multicenter, double-masked, randomized, placebo-controlled study.Analysis 69 patients with keratitis-related progressive randomized aganirsen (34 patients)...
The role of mitogen-activated protein kinase (MAPK) pathways in TGF-beta-induced myofibroblast transdifferentiation human tenon fibroblasts (HTFs) was investigated to identify potential pharmacologic targets for the inhibition scarring after glaucoma surgery.TGF-beta-dependent activation Smad2, p38, and Erk-1/2 examined by Western blot analysis. mRNA expression collagen Ialpha1, fibronectin, marker alpha smooth muscle actin (alpha-SMA) analyzed real-time RT-PCR. alpha-SMA subcellular...
purpose. Extracellular matrix (ECM) composition, tension, and rigidity modulate cell–ECM interactions have substantial impact on cell functions. The authors studied the effects of ECM human trabecular meshwork (HTM) cells to assess as a possible pathophysiologic factor in glaucoma. methods. Trabecular derived from donor cornea rings passaged three seven times were plated collagen-coated tissue culture plastic or polyacrylamide gels different rigidity. Cell spreading focal adhesions assessed...
purpose. To assess the significance of Rho-kinase–dependent contractility in TGF-β–induced myofibroblast transdifferentiation human tenon fibroblasts to characterize possible pharmacological targets for inhibition postoperative scarring after glaucoma surgery. methods. Human (HTFs) were grown culture and stimulated with TGF-β1. The effect TGF-β on Rho-GTPase activity was assessed by GST-rhotekin binding domain pulldown assay detected Western blot analysis. Contractility evaluated a silicone...
purpose. The transdifferentiation of Tenon fibroblasts to myofibroblasts is a pivotal step in filtering bleb scarring. It mediated by the cytokine TGF-β, Rho-dependent contractility, and cell–matrix interactions an interdependent fashion. HMG-CoA-reductase inhibitors (statins) have been shown inhibit Rho-GTPase signaling; therefore, authors studied influence lovastatin on TGF-β–mediated myofibroblast assess potential use statins wound healing modulation. methods. Human were grown culture,...
The aim of this study was to evaluate the reliability tear film osmolarity as a diagnostic tool for detecting dry eye disease (DED) in patients with rheumatoid arthritis (RA). second determine whether there is relationship between osmolarity, commonly used RA score, and blood tests RA.A group 74 but without any previously established diagnosis DED at University Hospital Wurzburg examined. A Modified Dry Eye Severity Score calculated based on Schirmer test, break-up time, ocular surface index...
Purpose.: Extracellular matrix and the cytokine TGF-β influence scar formation in an interdependent fashion. In this study, impact of extracellular elasticity on TGF-β–induced signal transduction myofibroblast transdifferentiation was examined. Methods.: Primary human tenon fibroblasts were seeded collagen-coated glass coverslips (rigid environment) or collagen polyacrylamide gels (elastic different compliance stimulated with TGF-β. Myofibroblast assessed by reverse...
To evaluate tear film osmolarity (TFO) as a diagnostic tool for detecting chronic ocular graft-versus-host disease (GVHD) in patients after hematopoietic stem cell transplantation and to assess its correlation with the new international GVHD score.A group of 204 consecutive who underwent at University Hospital Wuerzburg Germany received an ophthalmologic examination transplantation. TFO was measured score calculated based on Schirmer test, corneal fluorescein staining, conjunctival...
Purpose: Corneal epithelial wound healing is a major issue in ocular surface (OS) reconstruction. Aim of this study was to evaluate parameters vitro on transparent keratin films (KFs) derived from human hair comparison with amniotic membrane (AM) and polystyrene.Materials Methods: The corneal cell line (HCE-T) expanded KF, AM commercially available 24-well polystyrene culture plates compare proliferation, migration attachment by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide,...
Uveamelanome sind die häufigsten malignen Augentumoren. Mit modernen molekularbiologischen Methoden (Chromosom-3-Typisierung, Genexpressionsanalyse) können weniger aggressive von hoch aggressiven Verlaufsformen (Monosomie 3, Klasse II) unterschieden werden. Diese molekularbiologische Stratifizierung hat bisher ausschließlich eine Bedeutung für Risikoeinschätzung, da es keine wirksame Therapie gibt, Metastasierung verhindern oder verzögern kann. Eine randomisierte Studie mit einer...
Abstract Purpose To evaluate the outcome of phacoemulsification in patients with chronic ocular Graft-versus-host disease (oGVHD) after allogeneic hematopoietic stem cell transplantation (aHSCT). Methods Retrospective, observational multicenter study from 1507 oGVHD patients. From patient files, data were collected including best-corrected visual acuity (BCVA), intraocular pressure (IOP), Schirmer’s test I , tear film break-up time (TFBUT), corneal fluorescein staining score, postoperative...