A5052833932- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Ophthalmology and Eye Disorders
- Retinal Diseases and Treatments
- Intraocular Surgery and Lenses
- Ocular Surface and Contact Lens
- Ocular Infections and Treatments
- Retinopathy of Prematurity Studies
- Ocular Diseases and Behçet’s Syndrome
- Corneal Surgery and Treatments
- Ocular Oncology and Treatments
- Medical and Health Sciences Research
- Migraine and Headache Studies
- Retinal and Optic Conditions
- Biomedical and Chemical Research
- Cerebral Venous Sinus Thrombosis
- Retinal Imaging and Analysis
- Retinal and Macular Surgery
- Sympathectomy and Hyperhidrosis Treatments
- Neurological Disorders and Treatments
- Dermatologic Treatments and Research
- Traumatic Ocular and Foreign Body Injuries
- Pituitary Gland Disorders and Treatments
- Optical Coherence Tomography Applications
- Cell Adhesion Molecules Research
Johannes Gutenberg University Mainz
1994-2024
University Medical Center of the Johannes Gutenberg University Mainz
2019-2024
Universitätsklinikum Würzburg
2012-2023
Augenklinik Universitätsklinikum Würzburg
2009-2023
University of Würzburg
2010-2023
University Medical Center
2018-2019
Santen (United States)
2019
Allergan (Ireland)
2019
Santen (Japan)
2019
Allergan (United Kingdom)
2019
Resource utilisation and direct costs associated with glaucoma progression in Europe are unknown. As population progressively ages, the economic impact of disease will increase.From a total 1655 consecutive cases, records 194 patients were selected stratified by severity. Record selection was based on diagnoses primary open angle glaucoma, suspect, ocular hypertension, or normal tension glaucoma; 5 years minimum follow up required. Glaucoma severity assessed using six stage staging system...
Abstract Purpose To compare the outcomes of canaloplasty and trabeculectomy in open‐angle glaucoma. Methods This prospective, randomized clinical trial included 62 patients who randomly received ( n = 32) or 30) were followed up prospectively for 2 years. Primary endpoint was complete (without medication) qualified success (with without defined as an intraocular pressure IOP ) ≤18 mmHg (definition 1) ≤21 ≥20% reduction 2), ≥5 mmHg, no vision loss further glaucoma surgery. Secondary endpoints...
PROLOGUE:
Purpose: The dynamic contour tonometer (DCT, Pascal tonometer, Swiss Microtechnology AG, Port, Switzerland) was recently introduced as a new method of intraocular pressure measurement, supposedly independent corneal properties. In this study we analyzed the agreement and correlation tonometry Goldmann applanation (GAT) investigated influence central thickness (CCT) curvature. We also considered preferential patient groups for both methods. Methods: prospective 100 eyes without glaucoma,...
The role of mitogen-activated protein kinase (MAPK) pathways in TGF-beta-induced myofibroblast transdifferentiation human tenon fibroblasts (HTFs) was investigated to identify potential pharmacologic targets for the inhibition scarring after glaucoma surgery.TGF-beta-dependent activation Smad2, p38, and Erk-1/2 examined by Western blot analysis. mRNA expression collagen Ialpha1, fibronectin, marker alpha smooth muscle actin (alpha-SMA) analyzed real-time RT-PCR. alpha-SMA subcellular...
purpose. Extracellular matrix (ECM) composition, tension, and rigidity modulate cell–ECM interactions have substantial impact on cell functions. The authors studied the effects of ECM human trabecular meshwork (HTM) cells to assess as a possible pathophysiologic factor in glaucoma. methods. Trabecular derived from donor cornea rings passaged three seven times were plated collagen-coated tissue culture plastic or polyacrylamide gels different rigidity. Cell spreading focal adhesions assessed...
purpose. To assess the significance of Rho-kinase–dependent contractility in TGF-β–induced myofibroblast transdifferentiation human tenon fibroblasts to characterize possible pharmacological targets for inhibition postoperative scarring after glaucoma surgery. methods. Human (HTFs) were grown culture and stimulated with TGF-β1. The effect TGF-β on Rho-GTPase activity was assessed by GST-rhotekin binding domain pulldown assay detected Western blot analysis. Contractility evaluated a silicone...
<b>Aim:</b> To evaluate the influence of clear cornea phacoemulsification on filtering bleb morphology, function, and intraocular pressure (IOP) in glaucomatous eyes with previously successful surgery. <b>Methods:</b> The clinical course 30 patients (30 eyes) who underwent after glaucoma surgery was prospectively evaluated. Mean IOP morphology (standardised assessment criteria score 0–12, 12 = optimum) were determined before surgery, 3 days, 6 months, months control group consisted 36...
purpose. The transdifferentiation of Tenon fibroblasts to myofibroblasts is a pivotal step in filtering bleb scarring. It mediated by the cytokine TGF-β, Rho-dependent contractility, and cell–matrix interactions an interdependent fashion. HMG-CoA-reductase inhibitors (statins) have been shown inhibit Rho-GTPase signaling; therefore, authors studied influence lovastatin on TGF-β–mediated myofibroblast assess potential use statins wound healing modulation. methods. Human were grown culture,...
Purpose.: To gain further insight into a possible role of biomechanical cues in glaucoma, the authors assessed influence extracellular matrix (ECM) elasticity on TGF-β2–induced changes trabecular meshwork (TM) cells. Methods.: Human TM cells derived from donor cornea rings were plated rigid collagen-coated tissue culture plastic or polyacrylamide gels different and treated with vehicle TGF-β2. Activation Smad-2/3, ERK, AKT signaling expression α-SMA PAI-1 proteins by Western blot analysis....
Purpose To investigate the morphologic changes in trabecular meshwork a case series of eyes with pigment dispersion syndrome and pigmentary glaucoma, surgical trabeculectomy specimens from glaucoma. Materials Methods Trabecular meshworks 6 whole 3 donors 7 were studied by light electron microscopy. Axonal counts correlated qualitative quantitative data changes. Results Changes varied around circumference eyes, but all most regions there numerous granules within cells; was not found...
Cataract and glaucoma are both common comorbidities among older patients. Combining surgery with minimal invasive phacoemulsification (phaco) is a considerable option to treat conditions at the same time, although combination filtration can produce strong inflammatory response. Combined non-penetrating procedures like canaloplasty have shown reduce intraocular pressure (IOP) comparable trabeculectomy without risk of serious bleb-related complications. The purpose this retrospective study was...
To evaluate quality of life (QoL) with a new questionnaire after canaloplasty (CP) and trabeculectomy (TE).We assessed outcomes surgery, rate revision surgeries, patients' mood, influence postoperative care on QoL, surgery interference daily activities, postsurgical complaints. Patients completed the QoL 24 months surgery.Patients who underwent CP (n=175) were compared to TE patients (n=152). In group, 57% expressed high satisfaction, while 41% in group said they highly satisfied. The...
purpose. To obtain experimental in vivo information on the functional properties of myocilin for aqueous humor (AH) outflow and to study processing mutated Tyr437His myocilin. Myocilin is a secreted glycoprotein that some forms primary open-angle glaucoma (POAG), patients with mutation have severe phenotypes. methods. The chicken βB1-crystallin promoter was used overexpress wild-type human lenses transgenic mice. Expression mRNA monitored by Northern blot analysis situ hybridization....