A5006255873- Connexins and lens biology
- Intraocular Surgery and Lenses
- Ophthalmology and Visual Impairment Studies
- Glaucoma and retinal disorders
- Hematopoietic Stem Cell Transplantation
- Biochemical effects in animals
- Ocular Surface and Contact Lens
- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Neonatal Health and Biochemistry
- Oral health in cancer treatment
- Acute Lymphoblastic Leukemia research
- Retinal Imaging and Analysis
- Salivary Gland Disorders and Functions
- Aldose Reductase and Taurine
- Ocular and Laser Science Research
- Yersinia bacterium, plague, ectoparasites research
- Optical Imaging and Spectroscopy Techniques
- Biomedical Research and Pathophysiology
- Advanced Glycation End Products research
- Childhood Cancer Survivors' Quality of Life
- Systemic Sclerosis and Related Diseases
- Heat shock proteins research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
National Institutes of Health
2005-2021
National Eye Institute
2012-2021
SRM Institute of Science and Technology
2020
Bharathiar University
2020
Antwerp University Hospital
2016
Addenbrooke's Hospital
2016
Sanford Research
2016
STMicroelectronics (France)
2001
United States Department of Health and Human Services
1993-1995
Johns Hopkins University
1983-1989
The 2005 National Institutes of Health (NIH) Consensus Conference proposed new criteria for diagnosing and scoring the severity chronic graft-versus-host disease (GVHD). 2014 NIH consensus maintains framework prior with further refinement based on evidence. Revisions have been made to address areas controversy or confusion, such as overlap GVHD subcategory distinction between active past tissue damage. Diagnostic involvement mouth, eyes, genitalia, lungs revised. Categories should be defined...
Ocular chronic graft-versus-host disease (cGVHD) is one of the most frequent long-term complications after hematopoietic stem cell transplantation and often associated with significant morbidity reduced quality life.The German/Austrian/Swiss Consensus Conference on Clinical Practice in cGVHD aimed to summarize currently available evidence for diagnosis (topical) treatment different modalities ocular cGVHD. The presented consensus was based a review published survey current clinical practice...
Although xerostomia is a commonly reported complaint in patients with chronic graft-versus-host disease (cGVHD), criteria for evaluating the prevalence and characteristics of salivary gland involvement have not been well defined this patient population. Previous studies also made no distinction between mucosal oral cGVHD. We systematically evaluated signs symptoms sicca large cohort cGVHD (n = 101) using instruments widely used to study Sjogren's syndrome. Xerostomia was by 77% associated...
Between 2004 and 2010, 189 adult patients were enrolled on the National Cancer Institute's cross-sectional chronic graft-versus-host disease (cGVHD) natural history study. Patients evaluated by multiple scales outcome measures, including 2005 Institutes of Health (NIH) Consensus Project cGVHD severity scores. The purpose this study was to assess validity NIH scoring variables as determinants in severely affected efforts standardize clinician evaluation staging cGVHD. Out enrolled, 125 met...
At least half of patients with chronic graft-versus-host-disease (cGVHD), the leading cause morbidity and non-relapse mortality after allogeneic stem cell transplantation, have oral manifestations: mucosal lesions, salivary dysfunction, limited mouth-opening. cGVHD may manifest in a single organ or affect multiple systems, including mouth, eyes, skin. The interrelationship 3 manifestations each other specific extraoral has not been studied. In this analysis, we explored, large group cGVHD,...
To use dynamic light scattering to clinically assess early precataractous lens protein changes.We performed a cross-sectional study in 380 eyes of 235 patients aged 7 86 years with Age-Related Eye Disease Study clinical nuclear opacity grades 0 3.8. A light-scattering device was used alpha-crystallin, molecular chaperone shown bind other damaged proteins, preventing their aggregation. The outcome measure the alpha-crystallin index, unbound each lens. association index increasing and aging...
Biallelic mutations in the AP5Z1 gene encoding AP-5 ζ subunit have been described a small number of patients with hereditary spastic paraplegia (HSP) (SPG48); we sought to define genotype-phenotype correlations homozygous or compound heterozygous sequence variants predicted be deleterious.We performed clinical, radiologic, and pathologic studies 6 biallelic AP5Z1.In 4 patients, there was complete loss protein. Clinical features encompassed not only prominent paraparesis but also sensory...
To evaluate long-term survivors of high-grade non-Hodgkin's lymphomas (NHLs) for late effects and to attempt assess the relative contributions primary treatment modalities these effects.Of 103 young followed up 1 20 years, 74 patients were interviewed underwent various investigations, an additional 12 only. Of 86 patients, 65 had previously suffered from small non-cleaved-cell lymphoma, 16 lymphoblastic five large-cell lymphoma.Left ventricular dysfunction was identified in eight 57 (14.0%)...