A5047914147- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Ocular Infections and Treatments
- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Intraocular Surgery and Lenses
- Legionella and Acanthamoeba research
- Ophthalmology and Visual Impairment Studies
- Ocular Diseases and Behçet’s Syndrome
- Traumatic Ocular and Foreign Body Injuries
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Bartonella species infections research
- Vasculitis and related conditions
- Retinal and Macular Surgery
- Retinal Diseases and Treatments
- Rabies epidemiology and control
- Entomological Studies and Ecology
- Ocular Oncology and Treatments
- Medical and Biological Ozone Research
- Bacterial biofilms and quorum sensing
- Plant Pathogens and Fungal Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Occupational Health and Performance
- Heme Oxygenase-1 and Carbon Monoxide
Universitätsklinikum des Saarlandes
2015-2025
Ophthalmology Clinic
2015-2025
Saarland University
2016-2025
Rotterdam Eye Hospital
2024
German Medical Association
2024
University Medical Center Freiburg
2022
Klinikum Görlitz
2020
Martin Luther University Halle-Wittenberg
2018
Novem (Netherlands)
2018
Keratoconus (KC) is a progressive cone-shaped corneal protrusion that causes paracentral thinning at the apex of cone and typically occurs asymmetrically on both sides. After careful anamnesis classification degree severity targeted treatment appropriate to stage disease available. If visual acuity no longer sufficient, rigid gas-permeable contact lenses (CL) are fitted by specialist. Riboflavin UVA cross-linking (CXL) recommended in cases progression still useful for patient. Intracorneal...
Background/Objectives: Evaluation of stem cell, keratin, retinoic acid metabolism markers and non-coding micro-RNAs (miRNAs) in conjunctival corneal samples patients with epithelial basal membrane dystrophy (EBMD), Salzmann nodular degeneration (SND), pterygium congenital aniridia (CA), to detect similarities differences their pathogenesis. Methods: Impression cytology (IC) (CEs) EBMD, SND, pterygium, aniridia, healthy control subjects have been analyzed. The IC were subjected qPCR, the qPCR...
With the increasing demand for corneas, eye banks must optimize tissue donation, collection, and selection process. This retrospective monocentric study analyzed approval rates corneal donation origin of reasons discarding donor corneas from 2010 to 2019.
Abstract Background This study aims to evaluate visual outcome, central corneal thickness, and re-bubbling rate in a cohort with undersized sequential Descemet Membrane Endothelial Keratoplasty (DMEK) due endothelial graft decompensation following primary penetrating keratoplasty (PK). Methods All patients who received DMEK (n = 16) or triple 2) after failed PK between November 2020 June 2022 were retrospectively evaluated. Analyzed parameters corrected distance acuity (CDVA), thickness...
This study assesses the reliability of successive corneal biomechanical response measurements by Corneal Visualization Scheimpflug Technology (CST, Corvis ST® , Oculus Optikgeräte, Wetzlar, Germany) in different keratoconus (KC) stages.A total 173 eyes (15 controls: 15 eyes, and 112 KC patients: stages 1|1-2|2|2-3|3|3-4|4, n = 26|16|36|18|31|26|5 according to Topographical Classification, TKC) were repeatedly examined five times with CST, each after repositioning patient's head re-adjusting...
Descemet membrane endothelial keratoplasty (DMEK) accounts for >50% of all corneal transplants in Germany. So far, no data from such a large multicenter study have been published.This retrospective included 3200 DMEKs at seven departments performed Fuchs dystrophy (FECD) or bullous keratopathy (BK). We evaluated best corrected visual acuity (BCVA, logMAR), cell density (ECD, cells/mm2 ), minimal thickness (CT, μm), rebubbling-, primary transplant failure- and immune reaction-rate. Changes...
Background: To evaluate the outcomes of intravitreal faricimab (IVF) for refractory neovascular age-related macular degeneration (nAMD) and investigate impact baseline optical coherence tomography, biomarkers total IVF injections are needed. Methods: A retrospective analysis 33 eyes patients who completed one year (52 W) treatment with IVF. The received four (6 mg/0.05 mL) as upload phase. Thereafter, interval was extended to 8 or 12 weeks if disease activity not recorded. outcome measures...
Purpose: This study assesses the reliability of successive measurements tomographic parameters in different keratoconus (KC) stages with 2 devices. Methods: A total 125 eyes (13 controls: 24 eyes, and 73 patients KC: 1|2|3|4, n = 24|24|26|27 according to Topographical KC Classification) were repeatedly examined 5 times rotating Scheimpflug tomograph (Pentacam HR, Oculus, Wetzlar, Germany) an anterior segment optical coherence (Casia 2, Tomey, Nagoya, Japan). Outcome measures included 1) mean...
To report the indications and outcomes of 8.5/8.6-mm excimer laser-assisted penetrating keratoplasties (PKPs) at a tertiary corneal subspecialty referral center.This retrospective, descriptive, observational study included 107 PKPs performed in 96 patients (mean age, 53 ± 12 years). The patients' for surgery, best-corrected visual acuity, surface regularity index, asymmetry topographic astigmatism, central endothelial cell density, thickness, graft status were recorded preoperatively, 6...
Abstract Background Corneal confocal microscopy (CCM) allows visualizing slightest alterations within the corneal subbasal nerve plexus (SNP). Recent CCM studies based on analysis of three–five images per eye assumed a reduced fibre length (CNFL) in keratoconus (KC). Methods The SNP KC patients ( n = 23, 13 contact lens wearing, 10 noncontact wearing) and without 16) was examined by one patient. CNFL frame area calculated, tortuosity quantified measuring (a) amplitude curves (b) under curve...
To report the indications and outcomes of penetrating keratoplasties with a graft diameter > 8.5 mm in severe corneal diseases at Department Ophthalmology Saarland University Medical Centre.Retrospective (6 years), descriptive, observational.Thirty-five large-diameter (LDPKPs) 27 patients (mean age, 62 ± 22 years) were performed from March 2010 to December 2016. The indication for surgery, number previous transplantations, best-corrected visual acuity (BCVA) before intraocular pressure,...
To investigate expression of cytokines and ROS-related genes in stromal cells healthy keratoconus (KC) corneas.
Acanthameoba keratitis is a serious ophthalmological condition with potentially vision‐threatening prognosis. Early diagnosis and recognition of relapse, the detection persistent Acanthamoeba cysts, are essential for informing prognosis managing condition. We suggest use in vivo confocal microscopy not only to identify early signs relapse after keratoplasty patients keratitis, but also as an additional follow‐up tool antimicrobial crosslinking. This study shows that is, experienced hands,...
To evaluate the effectiveness of epithelium-off (epi-off) accelerated corneal crosslinking (A-CXL, 9 mW/cm2, 10 min) in adult keratoconus (KC) patients.The study included 151 KC corneas (124 patients) after A-CXL. The parameters best corrected visual acuity (BCVA) and tomographic readings (Pentacam HR, Oculus, Germany) were analysed at 24, 12 6 months preoperatively, prior to surgery; weeks, months, 1, 2 >2 years postoperatively. demarcation line was assessed by anterior segment optical...