A5080671044- Ocular Oncology and Treatments
- Cancer and Skin Lesions
- Nonmelanoma Skin Cancer Studies
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Intraocular Surgery and Lenses
- Retinal Development and Disorders
- Immunotherapy and Immune Responses
- Ocular Infections and Treatments
- Cutaneous Melanoma Detection and Management
- Ocular Disorders and Treatments
- Lymphoma Diagnosis and Treatment
- Genetic and rare skin diseases.
- Sarcoma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Retinal and Macular Surgery
- melanin and skin pigmentation
- Ocular Diseases and Behçet’s Syndrome
- Hedgehog Signaling Pathway Studies
- Brain Metastases and Treatment
- Retinal and Optic Conditions
- Vascular Tumors and Angiosarcomas
- Epigenetics and DNA Methylation
University Hospital Bonn
2014-2025
Universitäts-Augenklinik Bonn
2015-2024
University of Bonn
2014-2024
Centrum für Integrierte Onkologie
2023
Ophthalmology Clinic
2020-2023
Johanna-Etienne-Krankenhaus
2020
Ophthalmology Associates (United States)
2016
Emory University
2011-2012
Luzerner Kantonsspital
2012
Ludwig-Maximilians-Universität München
2012
Purpose: To present light and electron microscopic as well immunohistochemical findings after corneal cross-linking (CXL). Methods: Six keratoconus corneas CXL, 12 without 7 normal were examined by microscopy, indirect immunohistochemistry using antibodies against proapoptotic BAX, antiapoptotic survivin, BCL-2, anti–smooth muscle actin and, in part, transmission microscopy. Direct immunofluorescence with 4′6-diamidino-2-phenylindole was performed to analyze keratocytes/area the anterior,...
<b><i>Aims:</i></b> Vascular endothelial (VE) cadherin is a cell adhesion molecule localized at (EC) junctions. As major component of adherens junctions, its main function the maintenance and regulation EC integrity. In acute respiratory distress syndrome (ARDS), increased vascular permeability mechanism in pulmonary edema lung dysfunction. this study, VE-cadherin expression was investigated ARDS lungs control tissue as well an culture model....
Until now, Schnabel's cavernous optic nerve atrophy (SCONA) has solely been a histopathological diagnosis exhibiting variable degrees of (ON) with characteristic spaces filled acid mucopolysaccharides. We report the first correlation histopathologic findings spectral domain-optical coherence tomography (SD-OCT) imaging in SCONA. examined eye an index patient histopathologically identified SCONA who had undergone multimodal before enucleation for iris ring melanoma. The extent and three other...
Background The problem of access to medical information, particularly in low-income countries, has been under discussion for many years. Although a number developments have occurred the last decade (e.g., open (OA) movement and website Sci-Hub), everyone agrees that these difficulties still persist very widely, mainly due fact paywalls limit approximately 75% scholarly documents. In this study, we compare accessibility recent full text articles field ophthalmology 27 established institutions...
The BAP1 (BRCA1-associated protein 1) gene is associated with a variety of human cancers. With its product being nuclear ubiquitin carboxy-terminal hydrolase deubiquitinase activity, acts as tumor suppressor potential pleiotropic effects in multiple types. Herein, we focused specifically on uveal melanoma (UM) which mutations are metastasizing phenotype and decreased survival rates. We identified the carboxyl (UCH) domain major hotspot region for pathogenic high evolutionary action (EA)...
Emerging evidence suggests an inverse association between cancer and neurodegenerative diseases (NDD). Although phenotypically different, both display a significant imbalance in the ubiquitination/deubiquitination processes. Therefore, we particularly investigated expression of ubiquitin C-terminal hydrolases (UCHs: UCH-L1, UCH-L3, UCH-L5 BAP1), subfamily deubiquitinating enzymes (DUBs), using publically available datasets (GTEx, TCGA) observed altered 17 types. Interestingly, UCH-L1 (known...
Purpose: Epigenetic alterations in uveal melanoma (UM) are still neither well characterized, nor understood. In this pilot study, we sought to provide a deeper insight into the possible role of epigenetic pathogenesis UM and their potential prognostic relevance. To aim, comprehensively profiled histone post-translational modifications (PTMs), which represent features regulating chromatin accessibility gene transcription, formalin-fixed paraffin-embedded (FFPE) tissues, control cell lines,...
Cancer evolves from a combination of genetic and epigenetic abnormalities resulting in aberrant gene expression profiles as well altered epigenomic patterns. Epigenetic alterations such DNA methylation histone modification play an important role tumorigenesis. While the pathobiology uveal melanoma (UM) changes have been characterized, there is growing evidence suggesting that are also involved. We investigated whether modifications (global levels acetylation, methylation, ubiquitination)...
Several nomenclature and grading systems have been proposed for conjunctival melanocytic intraepithelial lesions (C-MIL). The fourth "WHO Classification of Eye Tumors" (WHO-EYE04) a C-MIL classification, capturing the progression noninvasive neoplastic melanocytes from low- to high-grade lesions, onto melanoma in situ (MIS), then invasive melanoma. This proposal was revised WHO-EYE05 system, which simplified C-MIL, whereby MIS subsumed into C-MIL. Our aim validate system using digitized...
Evaluation of: Bronkhorst IH, Ly LV, Jordanova ES et al. Detection of M2-macrophages in uveal melanoma and relation with survival. Invest. Ophthalmol. Vis. Sci. 52(2), 643–650 (2011).Tumor-associated macrophages have been related to a worse prognosis for survival several tumors, among them melanoma. In particular proangiogenic anti-inflammatory M2-type macrophages, contributory role tumor growth has described. This study demonstrated that most tumor-associated exhibited the M2-phenotype....