A5065243230- Blood properties and coagulation
- Platelet Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Erythrocyte Function and Pathophysiology
- Hemophilia Treatment and Research
- Venous Thromboembolism Diagnosis and Management
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Phagocytosis and Immune Regulation
- Protease and Inhibitor Mechanisms
- Music and Audio Processing
- Vitamin K Research Studies
- Cancer-related gene regulation
- Speech and Audio Processing
- Erythropoietin and Anemia Treatment
- Pharmacogenetics and Drug Metabolism
- Pregnancy and preeclampsia studies
- Hemoglobinopathies and Related Disorders
- Venomous Animal Envenomation and Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Speech Recognition and Synthesis
- Hormonal Regulation and Hypertension
- Speech and dialogue systems
- Renin-Angiotensin System Studies
University Hospital Bonn
2011-2024
Birla Institute of Technology and Science, Pilani - Goa Campus
2024
University of Bonn
2014-2021
Institute for Transfusion Medicine
2010-2019
Sigmund Freud Institut
2019
All India Institute of Medical Sciences
1988-2010
Imperial College London
2002-2010
All India Institute of Medical Sciences Raipur
2008
All India Institute of Medical Sciences Bhopal
2008
Department of Biotechnology
2007
The dimeric FXIII-A2, a pro-transglutaminase is the catalytic part of heterotetrameric coagulation FXIII-A2B2 complex that upon activation by calcium binding/thrombin cleavage covalently cross-links preformed fibrin clots protecting them from premature fibrinolysis. Our study characterizes recently disclosed three binding sites FXIII-A concerning evolution, mutual crosstalk, thermodynamic profile, substrate binding, and interaction with other similarly charged ions. We demonstrate unique...
Von Willebrand disease (VWD) is the most common inherited bleeding disorder caused by quantitative or qualitative defects of von factor (VWF). VWD classified into three types--type 1 (partial deficiencies), type 2 (qualitative defects) and 3 (complete deficiency VWF). In this study we explored genotype phenotype characteristics patients with aim dissecting distribution mutations in different types VWD. One hundred fourteen belonging to 78 families diagnosed have were studied. Mutation...
The activation and regulation of coagulation Factor XIII (FXIII) protein has been the subject active research for past three decades. Although discrete evidence exists on various aspects FXIII a combinatorial structure/functional view in this regard is lacking. In study, we present results structure/function study functional chain events FXIII. Our shows how subtle chronological submolecular changes within calcium binding sites can bring about detailed transformation zymogenic to its...
The BAP1 (BRCA1-associated protein 1) gene is associated with a variety of human cancers. With its product being nuclear ubiquitin carboxy-terminal hydrolase deubiquitinase activity, acts as tumor suppressor potential pleiotropic effects in multiple types. Herein, we focused specifically on uveal melanoma (UM) which mutations are metastasizing phenotype and decreased survival rates. We identified the carboxyl (UCH) domain major hotspot region for pathogenic high evolutionary action (EA)...
Severe hereditary coagulation factor XIII deficiency is a rare homozygous bleeding disorder affecting one person in every two million individuals. In contrast, heterozygous more common, but usually not associated with severe hemorrhage such as intracranial or hemarthrosis. most cases, the disease caused by F13A gene mutations. Causative mutations F13B are rarer.We analyzed ten index patients and three relatives for activity using photometric assay sequenced their genes. Additionally,...
Hypomethylation of long interspersed element (LINE)-1 has been observed in tumorigenesis when using degenerate assays, which provide an average across all repeats. However, it is unknown whether individual LINE-1 loci or different CpGs within one specific promoter are equally affected by methylation changes. Conceivably, studying changes at may be more informative than global assays for cancer diagnostics. Therefore, with the aim mapping single-CpG resolution and exploring diagnostic...
Coronavirus disease 2019 (COVID-19), with a broad range of clinical and laboratory findings, is currently the most prevalent medical challenge worldwide. In this disease, hypercoagulability hyperinflammation, two common features, are accompanied by higher rate morbidity mortality. We assessed association between baseline inflammatory cytokine levels coagulopathy outcome in COVID-19. One hundred thirty-seven consecutive patients hospitalized COVID-19 were selected for study. Baseline...
A number of prothrombotic and fibrinolytic disorders may lead to venous thrombosis. 4G/5G polymorphism located in the promoter region plasminogen activator inhibitor-1 (PAI-1) gene has been found be commonly associated with levels PAI-1 might a risk factor for deep vein thrombosis (DVT). The aim this study was look potential association DVT Asian Indian population.A total 110 consecutive patients (M:F = 62:48) idiopathic equal age- sex-matched healthy controls were participants. All...
Severe factor XIII (FXIII) deficiency is a rare autosomal recessive coagulation disorder affecting one in two million individuals. The aim of the present study was to screen for and analyse F13B gene defects German population. A total 150 patients presenting with suspected FXIII patient severe (homozygous) were screened mutations F13A genes. Twenty-five individuals presented detectable heterozygous mutations, 12 them 13 gene. We report on genotype-phenotype correlations showing Direct...
Sulfonylureas (SUs) are still among the mostly prescribed antidiabetic drugs with an established mode of action: release insulin from pancreatic β-cells. In addition, effects SUs on adipocytes by activation nuclear receptor peroxisome proliferator-activated γ (PPARγ) have been described, which might explain their insulin-sensitizing potential observed in patients. However, there is a discrepancy between impact action and rather moderate vitro effect PPARγ transcriptional activity. Recent...
Background: Homozygosity for MTHFR C677T polymorphism can lead to significantly high homocysteine levels and hyperhomocysteinemia is an important risk factor thrombotic events. Aims: The aim was determine role of in North Indians with ischemic stroke. Settings Design: In a prospective study, the subjects stroke were recruited from neurology clinic hospital. Controls healthy individuals Hematology without any history Materials Methods: Plasma measured by enzyme immuno assay method after 3...
Congenital afibrinogenemia (OMIM #202400) is a rare coagulation disorder that was first described in 1920. It transmitted as an autosomal recessive trait characterized by absent levels of fibrinogen (factor I) plasma. Consanguinity Pakistan and its neighboring countries has resulted higher number cases congenital deficiency their respective populations. This study focused on the detection mutations genes using DNA sequencing molecular modeling missense all three [Fibrinogen gene alpha (FGA),...
Aims: In hemolysis, which is accompanied by increased levels of labile redox-active heme and often associated with hemostatic abnormalities, a decreased activity activated protein C (APC) routinely detected. APC versatile enzyme that exerts its anticoagulant function through inactivation clotting factors Va VIIIa. has not been demonstrated to be affected as described for other and, thus, subject investigation. Results: We report the interaction impact on employing spectroscopic...