A5031167621- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Hemoglobinopathies and Related Disorders
- Mesenchymal stem cell research
- COVID-19 Clinical Research Studies
- Platelet Disorders and Treatments
- Iron Metabolism and Disorders
- Pancreatitis Pathology and Treatment
- Trace Elements in Health
- Venous Thromboembolism Diagnosis and Management
- Pharmacogenetics and Drug Metabolism
- Immune Cell Function and Interaction
- Blood groups and transfusion
- Pediatric health and respiratory diseases
- Mobile Health and mHealth Applications
- Autophagy in Disease and Therapy
- Blood Pressure and Hypertension Studies
- Liver physiology and pathology
- COVID-19 and healthcare impacts
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Bone health and treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Dermatological and COVID-19 studies
- Blood donation and transfusion practices
Yasuj University of Medical Sciences
2016-2025
Iran University of Medical Sciences
2021
High Institute for Education and Research in Transfusion Medicine
2016-2020
Isfahan Fertility and Infertility Center
2016
Background Transfusion-transmitted infections (TTI) are among the most critical challenges of blood transfusion. Patients with lower health literacy can have adverse consequences for transfusion and due to lack standard tools measuring related TTI, this study was conducted develop a standardized tool assessing Health associated TTI. Aim This aimed Material Methods cross-sectional analytical development validation type, according definitions provided literacy, questions were designed in five...
Coronavirus disease 2019 (COVID-19), with a broad range of clinical and laboratory findings, is currently the most prevalent medical challenge worldwide. In this disease, hypercoagulability hyperinflammation, two common features, are accompanied by higher rate morbidity mortality. We assessed association between baseline inflammatory cytokine levels coagulopathy outcome in COVID-19. One hundred thirty-seven consecutive patients hospitalized COVID-19 were selected for study. Baseline...
Leukemic cells facilitate the creation of tumor-favorable microenvironment in bone marrow niche using their secreted factors. There are not comprehensive details about immunosuppressive properties chronic myelogenous leukemia-derived exosomes stromal and immune compartment. We explained here that K562-derived could affect gene expression, cytokine secretion, nitric oxide (NO) production, redox potential human primary cord blood-derived T (CB cells).Human were treated with exosomes. evaluated...
A predominant challenge in developing curative leukemia therapy is interactions of leukemic cells with the bone marrow stromal microenvironment. We aimed to investigate role cells, such as mesenchymal (BMSCs) and osteoblasts (OBs), curcumin (CUR) daunorubicin (DNR) induced apoptosis acute myeloid (AML) cells. used KG1 U937 cell line models treated them CUR DNR. The were then co-cultured BMSCs or a combination OBs feeders. After 24 hours co-culture, sorted separated from levels analyzed by...
Although the efficacy of MSCs on liver fibrosis is investigated, it not exactly clear whether released molecules by are sufficient to mediate anti-fibrotic effects or not. In this study, possible hepatoprotective human umbilical cord derived conditioned medium (UC-CM) was investigated. 30 male rats were divided into 3 groups (n = 10): C: control; F: intraperitoneally injected with CCl4 (1 ml/kg, i.p); F/UC-CM: that received UC-CM (100 µg/kg, i.v). At end 12th week, serum and samples...
Objective: First-time blood donors are the most common group of donors.They usually have different motivations for donation, some which provoke to hide risk factors transfusion-transmissible infections (TTIs).Therefore, detection TTIs among first-time is crucial and can decrease rate recipients.This study aimed evaluate prevalence in transfusion center Kohgiluyeh Boyer-Ahmad Province (KBTC), Iran. Materials Methods:This retrospective was conducted with volunteer 2004-2014 KBTC.Various data,...
Abstract Microvesicles (MVs) derived from bone marrow niche components have an important role in genetic reprogramming and subsequent drugs induce apoptosis leukemic cells. Here, we found that undertreatment of curcumin or daunorubicin, the cross‐talk through MVs KG‐1‐bone mesenchymal stem cells (BMSCs), significantly downregulates expression survival gene osteopontin (OPN), CXCL‐12, IL‐6 (interleukin‐6), STAT‐3, VCAM‐1 (vascular cell adhesion molecule 1) treated‐KG‐1 as well exclusively...
A distinct set of mutations on the β-globin gene leads to dominantly inherited β-thalassemia (β-thal) that is associated with a disease phenotype in single mutant copy. We described molecular and hematological characteristics novel elongated chain combination known hemoglobin (Hb) variant (N-Baltimore or HBB: c.286A>G) cis. The highly unstable Hb caused typical features β-thal major (β-TM) intermedia (β-TI) two members family depending their α-globin genotypes. β allele mother was...
Background: Megakaryopoiesis is characterized by progressive polyploidization and the expression of megakaryocytic markers. Numerous transcription factors physiological signaling pathways regulate this phenomenon. Megakaryocyte differentiation induction in K562 cell line hematopoietic stem cells via nanocurcumin drug has been identified our previous study. are typical Chronic Myelogenous Leukemia (CML) that resistant to apoptosis express bcr-abl fusion gene. These have potential...
α-Thalassemia (α-thal) is a common genetic disorder in Iran and many parts of the world. Genetic defects on α-globin gene cluster can result α-thal that may develop clinical phenotype varying from almost asymptomatic to lethal hemolytic anemia. In present study, four Iranian individuals with hypochromic microcytic anemia, who revealed none known mutations responsible for α-thal, were subjected further investigations. The thalassemic these patients resulted abnormal RNA splicing sites owing...
Thalassemia, which is associated with compound complications, the most common hereditary anemia in world. The zinc level different patients thalassemias. This study aimed to determine status and its relationship demographic factors chelation therapy β-thalassemia major (β-TM) patients. cross-sectional was conducted on 102 (β-thal), Zinc evaluated subjects using atomic absorption method. results were analyzed through descriptive statistics, χ2 Mann-Whitney U tests. Of cases, 92 eligible...
Hb S (HBB: c.20A>T) and α- and/or β-thalassemia (α- β-thal) coinheritance is a common genetic disorder in regions with high prevalence of thalassemia sickle cell disease. The clinical manifestations this vary from mild to severe complications. Iran country incidence This study aimed evaluate the disease β-thal Iranian patients. In cross-sectional 2018–2019, total 47 participants abnormality, who were referred Zafar Thalassemia Clinic (Tehran, Iran), selected as group. Molecular analysis for...