A5009392601- Blood donation and transfusion practices
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Blood Coagulation and Thrombosis Mechanisms
- Hemophilia Treatment and Research
- Single-cell and spatial transcriptomics
- Immune Cell Function and Interaction
- Chronic Myeloid Leukemia Treatments
- Kruppel-like factors research
- Iron Metabolism and Disorders
- Mesenchymal stem cell research
- Blood properties and coagulation
- Cancer Immunotherapy and Biomarkers
- Toxin Mechanisms and Immunotoxins
- Extracellular vesicles in disease
- Cell death mechanisms and regulation
- Enzyme function and inhibition
- Digital Imaging for Blood Diseases
- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
- Blood transfusion and management
- Bacterial Genetics and Biotechnology
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Curcumin's Biomedical Applications
Birjand University of Medical Sciences
2016-2025
Menopause is a natural biological aging process characterized by the loss of ovarian follicular function and decrease estrogen levels. These hormonal fluctuations are associated with increased iron levels, which ultimately lead to accumulation. This study aims investigate effects Deferasirox on homeostasis hematopoiesis in ovariectomized rats Sixty-four female Wistar were divided into eight groups underwent ovariectomy surgery simulate menopause. Iron accumulation was induced through...
Background: Myocardial infarction (MI) is one of the most common causes death globally. Since a comprehensive study on relationship between coagulation factors in AMI patients and opium consumption has not been done, this effect number I, II, VII, IX, XI with myocardial ST-elevated (STEMI) was investigated. Furthermore, our results shed light thrombosis grades. Methods: In case-control study, 80 STEMI referred to Razi Birjand Hospital, Iran, years 2021 2022 were divided into two groups...
Immunotherapy is changing the Head and Neck Squamous Cell Carcinoma (HNSCC) landscape improving outcomes for patients with recurrent or metastatic HNSCC. A deeper understanding of tumor microenvironment (TME) required in light limitations patients' responses to immunotherapy. Here, we aimed examine how Nivolumab affects infiltrating Tregs HNSCC TME. We used single-cell RNA sequencing data from eight tissues isolated four donors before after treatment. Interestingly, study found that Treg...
A predominant challenge in developing curative leukemia therapy is interactions of leukemic cells with the bone marrow stromal microenvironment. We aimed to investigate role cells, such as mesenchymal (BMSCs) and osteoblasts (OBs), curcumin (CUR) daunorubicin (DNR) induced apoptosis acute myeloid (AML) cells. used KG1 U937 cell line models treated them CUR DNR. The were then co-cultured BMSCs or a combination OBs feeders. After 24 hours co-culture, sorted separated from levels analyzed by...
<title>Abstract</title> Menopause is a natural biological aging process characterized by the loss of ovarian follicular function and decrease estrogen levels. These hormonal fluctuations are associated with increased iron levels, which ultimately lead to accumulation. This study aims investigate effects Deferasirox on homeostasis hematopoiesis in ovariectomized rats Sixty-four female Wistar were divided into eight groups underwent ovariectomy surgery simulate menopause. Iron accumulation was...
Abstract Background Acute myocardial infarction (AMI) is a leading cause of death and morbidity around the world. Although association between thrombophilia AMI well-established, controversial data are present on thrombophilic polymorphisms AMI. The aim this study was to investigate three including factor V Leiden ( FVL ), MTHFRC677T (methylenetetrahydrofolate reductase), Coagulation XIIIVal34Leu with in East Iran. Result There were no statistically significant differences patients control...
As one of the induced pluripotent stem cells (iPSCs) methods, spermatogonial (SSCS ) extract is considered as new approach in cell therapy infertility. 5-aza-2'-deoxycytidine (5-aza-dC) inhibits methyltransferase enzyme, and induces gene reprogramming; herein, effects SSCS incubation 5-aza-dC-treated bone marrow mesenchymal (BMMSCs) has been surveyed. BMMSCs were isolated from femurs three to four weeks old male NMRI mice, at passage treated with 2 µM 5-aza-dC for 72 hours. SSCs isolated,...
Neutrophil-lymphocyte (NLR), platelet-lymphocyte (PLR), eosinophil-lymphocyte (ELR), and monocyte-lymphocyte (MLR) ratios are systemic inflammatory markers related to myocardial infarction. The aim of this study is investigate the association Src homology 2-B adapter protein 3 (SH2B3) C784 T methylenetetrahydrofolate reductase (MTHFR) C677 polymorphisms (SNP) with severity coronary artery disease (CAD) in 150 ST-elevation infarction (STEMI) patients. Single nucleotide were genotyped using...
Background: Helicobacter pylori is classified as a carcinogen, and it also the most common cause of chronic bacterial infection peptic ulcers. Approximately 45% people are infected with bacterium. Methods: In this study, H. genes, CagA VacA, were investigated in drinking water, using 100 samples (50 from municipal water supply 50 effluent household treatment devices). DNA was extracted colonies positive heterotrophic plate count (HPC) for use molecular testing microbial identification. The...
Diabetic retinopathy (DR) is expanding to epidemic levels globally due the progressing prevalence of diabetes mellitus (DM). In this study, association between factor V Leiden (
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy that represents significant challenge in cancer research and clinical management. In this study, we reanalyzed published single-cell RNA sequencing (scRNA-seq) dataset from PDAC adjacent tissues to investigate the heterogeneity of tumor normal tissue, specifically focusing on regulatory T cells (Tregs) their interactions with other microenvironment (TME). Treg were identified clustered into natural Tregs (nTreg) induced...
<title>Abstract</title> Rheumatoid arthritis (RA), an inflammatory illness characterized by joint inflammation and cartilage erosion, currently has limited therapeutic options due to adverse effects. In experimental model, human dermal fibroblast (HDF) cells expressing miR-192 platelet-rich plasma (PRP) were applied alleviate RA symptoms. RT-PCR measured COL1A2 gene expression after transfecting HDF increasing the MIR-192 expression. Male Wistar rats injected with 100 µl CFA into foot pad...