A5019373203- Nasolacrimal Duct Obstruction Treatments
- Ocular Surface and Contact Lens
- Cancer and Skin Lesions
- Sinusitis and nasal conditions
- Glaucoma and retinal disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Ophthalmology and Eye Disorders
- Oral and Maxillofacial Pathology
- Corneal Surgery and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Acne and Rosacea Treatments and Effects
- Ocular Oncology and Treatments
- Ocular Infections and Treatments
- Corneal surgery and disorders
- Intraocular Surgery and Lenses
- Infectious Diseases and Mycology
- Porphyrin Metabolism and Disorders
- Biomedical Research and Pathophysiology
- Ocular Disorders and Treatments
- Wound Healing and Treatments
- Proteoglycans and glycosaminoglycans research
- Actinomycetales infections and treatment
- Retinal Development and Disorders
- Pneumothorax, Barotrauma, Emphysema
Federal State Scientific Institution Research Institute of Eye Diseases
2018-2025
Helmholtz Moscow Research Institute of Eye Diseases
2015-2024
Academy of Medical Sciences
2015
BACKGROUND: In the literature, there is a deficit of data regarding clinical and morphological correlations in characterizing lacrimal drainage pathways. However, changes biomechanical properties pathways may influence picture dacryostenosis, also have predictive value context prognosis surgical procedures. AIM: The aim this study to viscoplastic sac wall dacryostenosis MATERIALS AND METHODS: included 38 patients with dacryostenosis. All underwent biometric examination determine average area...
Background The problem of access to medical information, particularly in low-income countries, has been under discussion for many years. Although a number developments have occurred the last decade (e.g., open (OA) movement and website Sci-Hub), everyone agrees that these difficulties still persist very widely, mainly due fact paywalls limit approximately 75% scholarly documents. In this study, we compare accessibility recent full text articles field ophthalmology 27 established institutions...
Background: Radioiodine ablation is a frequent procedure for the management of thyroid cancer. In several cases, this treatment followed by secondary acquired nasolacrimal duct obstruction (SALDO). Risk factors development SALDO are not defined yet.Aim - to provide clinical and demographic characteristics tearing in patients after radioiodine treatment.Materials methods: Material was obtained phone survey 588 who underwent treatment. Age gender respondent, strength administered medication,...
Purpose: To conduct a morphological study of structural changes in the nasolacrimal duct secondary acquired obstruction (SALDO) as result treatment with radioiodine. Methods: Twenty patients (20 cases) were involved: 10 cases at Hasner’s valve level due to radioiodine (group 1) and primary 2). During surgery, biopsy tissue from area was taken. A performed using semi-fine sections technique. Results: Patients group 1 showed following: desquamation columnar epithelium, pinpoint ulceration...
To study the antifibrotic effectiveness of mitomycin-C in tissues ostium site after it application for endonasal endoscopic dacryocystorhinostomy. The included 45 patients (48 cases) with primary obstruction nasolacrimal duct. All underwent dacryocystorhinostomy (EEDCR). At final stage operation, a swab MMC was placed region formed at concentration 0.2 mg/ml 3 min. An not intubated. After that, biopsies mucous nasal cavity and lacrimal sac were performed to morphological changes that occur...
Secondary acquired lacrimal duct obstruction (SALDO) is one of the complications radioiodine therapy. SALDO formed a few months after therapy if there sufficient uptake radioactive iodine by nasolacrimal duct. To date, risk factors leading to are unclear. The objective was determine correlation between tear production level and iodine-131 in ducts.Basal reflex studied 64 eyes prior with drug-induced hypothyroidism. condition ocular surface assessed using Ocular Surface Disease Index (OSDI)...
Ostium closure due to local reparative processes is the most common cause of recurrence after endoscopic endonasal dacryocystorhinostomy (DCR), but as yet poorly studied.To perform morphological study at osteotomy site DCR.The included 18 patients (18 women) aged 62.59±10.07 years with nasolacrimal duct obstruction, who underwent DCR (P.J. Wormald modification). Osteotomy biopsies were taken on days 2, 5, 7, 10, 14, 21, 28, and 60 surgery. All samples stained haematoxylin eosin. For further...
Optical coherence tomography (OCT) based lacrimal meniscometry is currently the most accurate method used to determine dimensions of tear meniscus. According related literature, latter gets reliably reduced after treatment nasolacrimal duct obstructions. However, relationship between morphometric parameters meniscus and intensity epiphora has not been established. Even an adequate study parameter yet identified.To investigate significance OCT in determining extent insufficiency drainage.A...
to compare the effectiveness of balloon dacryoplasty (DCP) for stenoses at different levels vertical portion lacrimal pathways and establish necessity consequent intubation.A total 120 clinical cases in 85 patients (66 females 19 males with mean age 53.61 ± 11.82 years) have been analyzed. Patients cervical stenosis sac constituted two groups: group 1 (19 patients, 30 DCP surgeries) 2 (22 surgeries Ritleng intubation). Two other groups consisted nasolacrimal orifice stenosis: 3 (21 4 (23...
To develop the optimal protocol for balloon dacryoplasty (DCP) through an experiment.The experiment enrolled 12 Chinchilla rabbits (24 eyes). DCP group 1 (5 rabbits, 10 eyes) implied two dilations of 90 and 60 sec followed by another same duration, while in 2 all four were sec. The was moved proximally before every third dilation. remaining (4 who did not receive constituted control group. animals killed on days 1, 3, 7, 14. In cases nasolacrimal duct morphology studied.By day 14 after...
Objective. To develop a method for investigating the perculiarities of structure nasolacrimal duct orifice according to data multislice computed tomography (MSCT). Material and methods . The was investigated in 96 cases 65 people, including healthy volunteers (n=29), patients with dacryostenosis (n=45), those unilateral dacryocystitis (n=22). type identified using developed procedure on basis contrast-enhanced MSCT lacrimal passages. For verification, investigators used retrograde probing...
Mitomycin-C (MMC) is the most frequently used agent for prevention of excessive scarring at osteotomy site after endoscopic endonasal dacryocystorhinostomy (EEDCR), which, however, being applied during final stage surgery, shows questionable effectiveness.to evaluate effectiveness a new administration route mitomycin C in EEDCR.The study included 86 patients (95 cases) age range 62.3±9 years with primary acquired nasolacrimal duct obstruction. All underwent P.J. Wormald modification EEDCR...
To develop surgical indications in dacryostenosis within the vertical portion of lacrimal pathways that would consider findings single-photon emission computed tomography (SPECT) combined with X-ray (CT).A total 96 patients isolated vertical-portion (127 cases) were enrolled. The examination included collecting Munk's scores for epiphora, optical coherence lower tear meniscus, scintigraphy, and SPECT/CT. Group 1 (40 was composed obstruction on CT, group 2 (87 - those whose proved passable....
Despite an obvious interest in the processes occurring lacrimal passages their obstruction, there is few articles analyzing biometric parameters.The study investigates characteristics of healthy individuals and patients with nasolacrimal duct obstruction.The included 81 cases partial obstruction 38 without tear drainage insufficiency. All underwent computed tomography dacryocystography. Analysis parameters involved calculation length, volume, average sectional area bony canal. The ratio...
Background: One of the main reasons failure in surgical treatment primary acquired nasolacrimal duct obstruction is excessive postoperative scarring dacryostomy. Despite variety procedures designed to prevent this, conflicting evidence their efficacy and safety provide incentive for further research antifibrotic therapeutics adjunctive use dacryocystorhinostomy.Aims: To evaluate effect pirfenidone on human nasal mucosal fibroblast cell culture.Materials methods: Human cultures were...
Fibrosis is the most important pathologic condition involved in undesirable outcomes of dacryocystorhinostomy. A number biochemical factors are currently known to have an effect on wound healing by promoting excessive scarring. Isoforms transforming growth factor β (TGF-β1) considered 'main' pro-fibrotic factor, but also affected other cytokines such as connective tissue (CTGF), which stimulates fibrosis, and fibroblast (FGF-2), acts antagonist it.To investigate correlations between...
Introduction Knowing a concentration at which cytostatic drugs are toxic for the nasal fibroblasts will enable use in clinical practice to prevent excessive cicatrization. Objective To determine concentrations of mitomycin С, doxorubicin, and 5-fluorouracil affecting mucosa fibroblasts. Methods We obtained material during an endonasal dacryocystorhinostomy with patient's informed consent. The cells were cultivated. Second- fourth-passage used experiments. stained vimentin cluster...
Introduction Studying the state of nasal cavity and its sinuses morphometric parameters inferior conchae, as well a comparative analysis obtained values in patients with primary (PANDO) secondary acquired nasolacrimal duct obstruction (SALDO), is relevant. Objective To study rhinological status PANDO) SALDO). Methods The present was based on results computed tomography (CT) dacryocystography PANDO ( n = 45) SALDO due to exposure radioactive iodine 14). control group included CT images...
To investigate the impact of nasal mucosa on outcomes dacryocystorhinostomy basis morphologic findings.The investigation enrolled 73 patients who had undergone endonasal endoscopic dacryocystorhinostomy. Nasal mucosal biopsies were intraoperatively taken from all patients. The obtained samples subjected to standard histological examination, as well immunohistochemical study using an anti-alpha-smooth muscle actin antibody. determine intensity inflammation in tissue sample, a chronic score...
Within the framework of article, authors analyzed available information about damage to lacrimal apparatus during radionuclide therapy. In focus article lesions production system, main and accessory glands, as well drainage are considered. It was found that is characteristic 131 I therapy for thyroid cancer, radioligand using anti-PSMA antibodies labeled with 177 Lu 225 Ac. Lu-PSMA Ac-PSMA may gland formation a clinically pronounced "dry eye syndrome". The pathogenesis such associated...