A5065847364- Lung Cancer Treatments and Mutations
- Ocular Oncology and Treatments
- Cancer Genomics and Diagnostics
- Thyroid Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Head and Neck Anomalies
- Immunotherapy and Immune Responses
- Lung Cancer Research Studies
- RNA modifications and cancer
- Cutaneous Melanoma Detection and Management
- Lung Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- Thyroid and Parathyroid Surgery
- Radiomics and Machine Learning in Medical Imaging
- Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Nonmelanoma Skin Cancer Studies
- Streptococcal Infections and Treatments
- Corneal Surgery and Treatments
- Ethics in Clinical Research
- Melanoma and MAPK Pathways
- Histiocytic Disorders and Treatments
Centre Hospitalier Universitaire de Nice
2016-2025
Hôpital Pasteur
2015-2024
Inserm
2015-2024
Institut de Recherche sur le Cancer et le Vieillissement de Nice
2015-2024
Université Côte d'Azur
2011-2024
Centre National de la Recherche Scientifique
2015-2024
Observatoire de la Côte d’Azur
2020-2024
Scientific Research Institute of Experimental and Clinical Medicine
2024
Centre Méditerranéen de Médecine Moléculaire
2024
Centre Antoine Lacassagne
2006-2023
The molecular mechanism responsible for the antitumor activity of histone deacetylase inhibitors (HDACi) remains elusive. As HDACi have been described to alter miRNA expression, aim this study was characterize HDACi-induced miRNAs and determine their functional importance in induction cell death alone or combination with other cancer drugs. Two HDACi, trichostatin A vorinostat, induced miR-129-5p overexpression, acetylation BCPAP, TPC-1, 8505C, CAL62 lines primary cultures papillary thyroid...
The oral fluoropyrimidine prodrug capecitabine is widely used in oncology. Capecitabine was designed to generate 5FU via the thymidine phosphorylase (TP) enzyme, preferentially expressed tumoral tissues. Hand-foot syndrome (HFS) a limiting toxicity of capecitabine. A pilot study on healthy volunteers conducted order test hypothesis that occurrence HFS could be related tissue-specific expression drug-metabolizing enzymes skin palm and sole. To this end, TP (activating pathway),...
The aim of this study was to compare the detection BRAF(V600E) by immunohistochemistry (IHC) using a mutation-specific antibody with molecular biology methods for evaluation papillary thyroid carcinoma (PTC) patients.This concerned 198 consecutive conventional PTC patients, which majority were women (133/198; 67%), mean age 56 years (range 19-79 years). BRAF mutation analysis performed DNA-based (direct sequencing, pyrosequencing, and SNaPshot) IHC (VE1 antibody) methods. sensitivity...
// Marius Ilie 1, 2, 3 , Catherine Butori Sandra Lassalle Simon Heeke 2 Nicolas Piton 4 Jean-Christophe Sabourin Virginie Tanga Kevin Washetine Elodie Long-Mira Priscilla Maitre Nathalie Yazbeck Olivier Bordone Lespinet Sylvie Leroy 5 Charlotte Cohen 6 Jérôme Mouroux Charles Hugo Marquette Véronique Hofman and Paul 1 Laboratory of Clinical Experimental Pathology, Pasteur Hospital, FHU OncoAge, University Côte d'Azur, Nice, France IRCAN Inserm U1081/CNRS 7284, Hospital-related Biobank...
// Sandra Lassalle 1, 2, 3, 4, 5, * , Joséphine Zangari Alexandra Popa 6 Marius Ilie 5 Véronique Hofman Elodie Long Martine Patey 7 Frédérique Tissier 8 Geneviève Belléannée 9 Hélène Trouette Bogdan Catargi 10 Isabelle Peyrottes 11 Jean-Louis Sadoul 12 Olivier Bordone Christelle Bonnetaud Catherine Butori Alexandre Bozec 13 Nicolas Guevara José Santini Imène Sarah Hénaoui Géraldine Lemaire 14 Blanck...
The number of genomic alterations required for targeted therapy non-squamous non-small cell lung cancer (NS-NSCLC) patients has increased and become more complex these last few years. These molecular abnormalities lead to treatment that provides improvement in overall survival certain patients. However, treated tumors inexorably develop mechanisms resistance, some which can be with new therapies. characterization the needs performed a short turnaround time (TAT), as indicated by...
Background/Objectives: Immune checkpoint inhibitors (ICIs) benefit some lung cancer patients, but their efficacy is limited in advanced adenocarcinoma (LUAD) with EGFR mutations (EGFRm), largely due to a non-immunogenic tumour microenvironment (TME). Furthermore, EGFRm LUAD patients often experience increased toxicity ICIs. CD73, an ectonucleotidase involved adenosine production, promotes immune evasion and could represent novel therapeutic target. This study investigates CD73 expression...
The aim of this study was to investigate the effects combining antiangiogenic treatment, epidermal growth factor receptor (EGFR) targeting and irradiation (RT). We evaluated AZD2171, a highly potent, orally active, vascular endothelial (VEGF) signalling inhibitor, gefitinib, an EGFR tyrosine kinase inhibitor RT. antitumour efficacy these treatments, administered alone in combination for 2 weeks, assessed VEGF-secreting human head neck tumour cell line, CAL33 that expresses EGFR, established...
The acute phase of Crohn's disease (CD) is characterized by a large afflux polymorphonuclear leukocytes (PMNL) into the mucosa and release TNF-α. Conversion inactive TNF-α an active form requires cleavage transmembrane precursor TNF-α-converting enzyme (ADAM17), protease mainly regulated tissue inhibitor metalloproteinase 3 (TIMP3). aim present study was to investigate in vitro model PMNL transepithelial migration intestinal patients with CD expression regulation ADAM17 TIMP3 epithelial...
Background: With the advent of formaldehyde standard law in France, and because impact new methods for diagnosis prognosis pathology, formalin replacement surgical pathology laboratories is currently being discussed France. However, a set criteria must be assessed before introducing substitute fixative. The objective this study was to compare fixation with cryoconservation tissues from several benign malignant thyroid pathologies respect morphology, antigenicity, nucleic acid (RNA, DNA,...