A5070388134- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Ophthalmology and Visual Impairment Studies
- Intraocular Surgery and Lenses
- Ocular Infections and Treatments
- Ophthalmology and Visual Health Research
- Simulation-Based Education in Healthcare
- Ocular Diseases and Behçet’s Syndrome
- Traumatic Ocular and Foreign Body Injuries
- Cerebral Venous Sinus Thrombosis
- Genomics and Phylogenetic Studies
- Surgical Simulation and Training
- Innovations in Medical Education
- Gut microbiota and health
- Medical and Biological Sciences
- Retinal and Optic Conditions
- Histiocytic Disorders and Treatments
- Sphingolipid Metabolism and Signaling
- Radiology practices and education
- Infectious Disease Case Reports and Treatments
- Ophthalmology and Eye Disorders
- Methemoglobinemia and Tumor Lysis Syndrome
- Optical Coherence Tomography Applications
Universitätsklinikum des Saarlandes
2016-2025
Ophthalmology Clinic
2016-2025
Saarland University
2014-2025
Rotterdam Eye Hospital
2024
Klinikum Görlitz
2020-2021
Vinci (United Kingdom)
2021
The purpose of this retrospective panel study was to provide an overview absolute numbers and trends in the types indications for corneal transplantation Germany from 2001 2016.A questionnaire about numbers, transplantation, sent 111 ophthalmologic departments Germany, out which 94 (85%) provided their data.Since year 2001, number transplantations has increased by 1.5-fold, 4730 penetrating keratoplasties (PKPs) 7325 lamellar 2016. shift procedures began 2006. In 2014, (231 [4%] anterior...
To optimize artificial intelligence (AI) algorithms to integrate Scheimpflug-based corneal tomography and biomechanics enhance ectasia detection.Multicenter cross-sectional case-control retrospective study.A total of 3886 unoperated eyes from 3412 patients had Pentacam Corvis ST (Oculus Optikgeräte GmbH) examinations. The database included 1 eye randomly selected 1680 normal (N) 1181 "bilateral" keratoconus (KC) patients, along with 551 topography very asymmetric (VAE-NT), their 474 ectatic...
Background/aims This retrospective multicentric panel study provides absolute numbers, types of and indications for corneal transplantation in Germany from 2011 to 2021 sets them into the international context. Methods A questionnaire was sent 104 German ophthalmologic surgery departments 93 (89%) provided their data. Results The number reported keratoplasties more than doubled (n=4474) (n=8998). Lamellar (49% posterior (n=2883), 4% anterior (n=231)) surpassed penetrating keratoplasty (PKP,...
Background This retrospective cross-sectional study aims to analyse the keratoconus (KC) stage distribution at different ages within Homburg Keratoconus Center (HKC). Methods 1917 corneae (1000 patients) were allocated decades of age, classified according Belin’s ABCD KC grading system and was analysed. Results 73 per cent (n=728) patients males, 27% (n=272) females. The highest prevalence occurred between 21 30 years (n=585 corneae, 294 patients). Regarding anterior (A) posterior (B)...
This retrospective cross-sectional study evaluated the potential of an additional biomechanical parameter 'E' as addition to tomographic ABCD ectasia/keratoconus (KC) staging.The Corvis Biomechanical Factor (CBiF) represents modified linear term Index (CBI) developed based on 448 KC corneas from Homburg Keratoconus Center (HKC). The CBiF range was divided into five stages (E0 E4) create a grading system according stages. Stage E0 characterized by values smaller than 2.5 percentile....
Keratoconus (KC) is a progressive cone-shaped corneal protrusion that causes paracentral thinning at the apex of cone and typically occurs asymmetrically on both sides. After careful anamnesis classification degree severity targeted treatment appropriate to stage disease available. If visual acuity no longer sufficient, rigid gas-permeable contact lenses (CL) are fitted by specialist. Riboflavin UVA cross-linking (CXL) recommended in cases progression still useful for patient. Intracorneal...
To investigate the relationship between corneal biomechanics and keratoconus (KC) severity as described by tomographic parameters.University-based German ophthalmology department.Retrospective cross-sectional study.A total of 448 KC corneas Homburg Keratoconus Center 112 healthy (448+112 patients) were examined Pentacam high-resolution Corneal Visualization Scheimpflug Technology (Pentacam HR Corvis ST). The population included a wide spectrum disease based on Belin's ABCD classification....
Keratoconus remains one of the leading indications for penetrating keratoplasty worldwide. Since it can be effectively stabilized today, its early diagnosis and progression assessment is particular importance. Detection are no longer limited to slit lamp examination corneal topography, but comprise nowadays increasingly tomography biomechanics. Because keratoconus has a decreased resistance deformation when compared healthy corneas, measuring analyzing behavior been reported enable...
While ophthalmologists relied primarily on learning the real human eye and performed their first surgical steps pig's in past, there exist nowadays multiple options for diagnostic simulation‐based education ophthalmology. These range from simple direct ophthalmoscopy simulators displaying pathologic fundus findings to indirect that provide both instructions information progress by recording analyzing examination process. Surgical cataract vitreoretinal surgery are very popular. An expansion...
Purpose To investigate the keratoconus characteristics and progression rate in a patient group of adolescents aged 19-24 years to compare results with young adults 25–30 years.
Evaluating the Predictability of Postoperative Target Refraction Using Prototype a New Intraoperative Aberrometer
Fellow eyes (FE) of 73 keratoconus (KC) patients with acute corneal hydrops (ACH) and 130 KC without ACH (total 236 eyes, 110 more severely affected), serving as control groups, were retrospectively analysed to identify potential risk factors associated the development ACH. Tomographic (Pentacam®) biomechanical analysis (Corvis ST®, both Oculus, Germany) performed. parameters are follows: K-max, thinnest thickness (TCT), Belin/Ambrósio deviation (BAD-D) tomographic ABCDE-staging....
Précis: Transscleral cyclophotocoagulation significantly reduces intraocular pressure and antiglaucomatous medication use post-penetrating keratoplasty, with low hypotony risk, particularly if delayed. Safe reintervention is feasible for recurrence. Purpose: (TSCPC) an established procedure lowering (IOP). We aimed to evaluate the therapeutic efficacy safety of TSCPC in patients refractory IOP elevation after penetrating keratoplasty (PK), as well identify risk factors associated...
With the increasing demand for corneas, eye banks must optimize tissue donation, collection, and selection process. This retrospective monocentric study analyzed approval rates corneal donation origin of reasons discarding donor corneas from 2010 to 2019.
Abstract The human microbiome emerges as a promising reservoir for diagnostic markers and therapeutics. Since host-associated microbiomes at various body sites differ diseases do not occur in isolation, comprehensive analysis strategy highlighting the full potential of should include diverse specimen types diseases. To ensure robust data quality comparability across diseases, we employ standardized protocols to generate sequencing from 1931 prospectively collected specimens, including...
This study assesses the reliability of successive corneal biomechanical response measurements by Corneal Visualization Scheimpflug Technology (CST, Corvis ST® , Oculus Optikgeräte, Wetzlar, Germany) in different keratoconus (KC) stages.A total 173 eyes (15 controls: 15 eyes, and 112 KC patients: stages 1|1-2|2|2-3|3|3-4|4, n = 26|16|36|18|31|26|5 according to Topographical Classification, TKC) were repeatedly examined five times with CST, each after repositioning patient's head re-adjusting...
Purpose: This study assesses the reliability of successive measurements tomographic parameters in different keratoconus (KC) stages with 2 devices. Methods: A total 125 eyes (13 controls: 24 eyes, and 73 patients KC: 1|2|3|4, n = 24|24|26|27 according to Topographical KC Classification) were repeatedly examined 5 times rotating Scheimpflug tomograph (Pentacam HR, Oculus, Wetzlar, Germany) an anterior segment optical coherence (Casia 2, Tomey, Nagoya, Japan). Outcome measures included 1) mean...
Abstract Background Corneal confocal microscopy (CCM) allows visualizing slightest alterations within the corneal subbasal nerve plexus (SNP). Recent CCM studies based on analysis of three–five images per eye assumed a reduced fibre length (CNFL) in keratoconus (KC). Methods The SNP KC patients ( n = 23, 13 contact lens wearing, 10 noncontact wearing) and without 16) was examined by one patient. CNFL frame area calculated, tortuosity quantified measuring (a) amplitude curves (b) under curve...
To investigate expression of cytokines and ROS-related genes in stromal cells healthy keratoconus (KC) corneas.
Simulation training is an important component of medical education. In former studies, diagnostic simulation for direct and indirect funduscopy was already proven to be effective method. this prospective controlled trial, we investigated the effect simulator-based fundus biomicroscopy training. After completing a 1-week ophthalmology clerkship, students at Saarland University Medical Center (n = 30) were block-randomized into two groups: The traditional group received supervised examining...
To evaluate the effectiveness of epithelium-off (epi-off) accelerated corneal crosslinking (A-CXL, 9 mW/cm2, 10 min) in adult keratoconus (KC) patients.The study included 151 KC corneas (124 patients) after A-CXL. The parameters best corrected visual acuity (BCVA) and tomographic readings (Pentacam HR, Oculus, Germany) were analysed at 24, 12 6 months preoperatively, prior to surgery; weeks, months, 1, 2 >2 years postoperatively. demarcation line was assessed by anterior segment optical...
Abstract Background To investigate the risk factors for keratoconus progression in children (10 – 18 years old; age group 1) compared to young adults (19 35 2) and middle-aged (36 55 3). Patients/Methods Ninety-seven children, 445 adults, 342 underwent total ophthalmic examination including clinical refraction, slit lamp examination, corneal tomography, eye biometry, biomechanical properties measurements. Comparisons were assessed among three groups between progressive nonprogressive eyes....