A5072801241- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Ocular Diseases and Behçet’s Syndrome
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Retinal and Macular Surgery
- Ocular Infections and Treatments
- Corneal Surgery and Treatments
- Vasculitis and related conditions
- Ophthalmology and Visual Impairment Studies
- Cerebral Venous Sinus Thrombosis
- Intraocular Surgery and Lenses
- Drug-Induced Ocular Toxicity
- Ocular Oncology and Treatments
- Vascular Malformations Diagnosis and Treatment
- Infection Control and Ventilation
- Dermatology and Skin Diseases
- Ophthalmology and Visual Health Research
- Pituitary Gland Disorders and Treatments
- Ocular and Laser Science Research
- Toxoplasma gondii Research Studies
- Ocular Surface and Contact Lens
- Rabies epidemiology and control
- Cutaneous Melanoma Detection and Management
Universitätsklinikum des Saarlandes
2017-2025
Ophthalmology Clinic
2017-2025
Saarland University
2018-2024
German Medical Association
2024
University Medical Center
2022-2023
University Hospital and Clinics
2023
Purpose: To assess the morphological and functional outcomes within first year of treatment with intravitreal brolucizumab for refractory neovascular age-related macular degeneration (nAMD). Methods: This retrospective study included 21 eyes from 19 patients nAMD followed 12 months. All were switched to after at least two other anti-vascular endothelial growth factors (VEGF). received 3x 6 mg/0.05 ml injections (IVI) monthly as an upload phase. Then IVI every 8 weeks interval adjustment if...
Increased risk of thromboembolic events has been associated with SARS-CoV-2 infections and more recently, COVID-19 vaccination. To date, however, there are no reports an association between the vaccination retinal artery occlusions. We report a case patient who developed central occlusion (CRAO) 2 days following administration AstraZeneca vaccine.A 76-year-old woman presented to our Department Ophthalmology complaining painless vision loss in her left eye 48 hours after she had received...
To investigate whether vaccination against SARS-CoV-2 is associated with the onset of retinal vascular occlusive disease (RVOD).In this multicentre study, data from patients central and branch vein occlusion (CRVO BRVO), artery (CRAO BRAO), anterior ischaemic optic neuropathy (AION) were retrospectively collected during a 2-month index period (1 June-31 July 2021) according to defined protocol. The relation any previous was documented for consecutive case series. Numbers RVOD COVID-19...
Abstract Purpose For the treatment of macular edema, in addition to use antivascular endothelial growth factors, steroids are also used intravitreally and sub-Tenon. Side effects include among others cataract formation elevation intraocular pressure (IOP). The aim this retrospective study was elicit IOP after administration various steroidal medication, time onset, efficacy administered IOP-lowering therapies. Methods We included 428 eyes with a postoperative ( n = 136), diabetic 148),...
To investigate the prevalence of geographic atrophy (GA) in advanced age-related macular degeneration (AMD) and proportion eyes that would meet indication criteria for treatment with first intravitreal anti-C3 agent (pegcetacoplan).This retrospective cross-sectional study included all AMD patients who visited Macular-Retina-Centre Oberkassel 2021. Eyes were classified according to stages. GA divided into two groups regarding foveal involvement. Baseline factors compared between (FGA)...
Background: To evaluate the outcomes of intravitreal faricimab (IVF) for refractory neovascular age-related macular degeneration (nAMD) and investigate impact baseline optical coherence tomography, biomarkers total IVF injections are needed. Methods: A retrospective analysis 33 eyes patients who completed one year (52 W) treatment with IVF. The received four (6 mg/0.05 mL) as upload phase. Thereafter, interval was extended to 8 or 12 weeks if disease activity not recorded. outcome measures...
To evaluate outcomes of intravitreal bevacizumab (IVB) treating macular edema (ME) after retinal vein occlusion (RVO) following pro re nata (PRN) regimen and investigate potential predictors non-response. Retrospective analysis 126 treatment-naive eyes with ME RVO. Eyes were treated initially IVB 1.25 mg/ml. Therapy was switched in case Outcome measures included best-corrected visual acuity (BCVA) central thickness (CMT), which recorded over 4 years treatment. BCVA improved significantly...
To assess the morphological and functional outcome of oral eplerenone for treatment patients with chronic central serous chorioretinopathy (CSC) in a real life experience.In this retrospective study, we reviewed clinical files 30 CSC. All were treated period 6 weeks or 3 months depending on response. Main measures included: best corrected visual acuity (BCVA), macular thickness (CMT) height subretinal fluid (SRF). Comparisons between responders non-responders performed to identify factors...
Purpose: To evaluate the outcome of excimer laser-assisted deep anterior lamellar keratoplasty (Exc-DALK) and penetrating (Exc-PKP) for keratoconus (KC). Methods: We included 123 eyes compared 30 undergoing big-bubble Exc-DALK after stromal debulking (G1) against a matched group 83 Exc-PKP ( G2 ) in our department. was created performing pseudorandom stratified bootstrapping PKP database starting with 2802 surgeries removal any bias. Main outcomes best corrected visual acuity (BCVA),...
To evaluate the results and complications of Descemet membrane endothelial keratoplasty (DMEK) in previously vitrectomized eyes.Retrospective study 35 eyes that had undergone DMEK, due to Fuchs corneal dystrophy (FECD), at our department with a follow-up after 6 months postoperatively. We compared intraoperative procedure, complications, DMEK between 14 pseudophakic (group 1) control group 21 non-vitrectomized 2).The unfolding time (in minutes) was significantly longer 1 than 2 (10.5 ± 6.4...
To detect the impact of intravitreal injection (IVI) therapy with sole anti-vascular-endothelial-growth-factor (VEGF) or combined steroids treating diabetic macular edema (DME) on activity proliferative retinopathy (PDR) based total number panretinal photocoagulation (PRP) spots needed within 2 years.A retrospective study 102 eyes primary-onset PDR and minimum follow-up 24 months divided into groups: Group 1 (G1) 40 received only PRP did not develop DME. (G2) 62 additional IVI-therapy due to...
To investigate the effectiveness of nonsteroidal anti-inflammatory eye drops (NSAIDs) combined with oral acetazolamide for postoperative macular edema (PME) after uncomplicated phacoemulsification (PE) and identify predictors non-response.We analyzed data PE identified eyes PME. First-line therapy included topical NSAIDs acetazolamide. In case non-response, triamcinolone was administered subtenonally. Outcome measures best-corrected visual acuity (BCVA) central thickness (CMT).94 out 9750...
To compare the effects of monotherapy with intravitreal ranibizumab, aflibercept and bevacizumab on retinal ganglion cell layer (RGCL) nerve fibre (RNFL) in patients naïve neovascular age-related macular degeneration (nAMD).This is a retrospective cohort study three-groups comparison. 83 97 eyes continuous an anti-vascular endothelial growth factor (anti-VEGF) were followed for 24 months divided into three groups according to anti-VEGF (aflibercept: 25 eyes, ranibizumab: 34 bevacizumab: 38...
To assess the morphological and functional outcome of intravitreal aflibercept following treat extend protocol compared to fixed for treatment eyes with neovascular age-related macular degeneration.This retrospective study included 126 113 patients primary onset degeneration who were followed 12 months. All treated 2 mg/0.05 mL aflibercept. received an upload three monthly injections. We subsequently studied two groups eyes. For group 1, 54 protocol. 2, 72 (fixed 2-monthly interval). Main...
Purpose: This study based on direct ophthalmoscopy (DO) teaching in medical curricula aimed to integrate both classic and simulator‐based DO techniques into the of students. Methods: 110 students received a multiple‐choice questionnaire (four theory questions, six fundus photographs) prior (EyeSi® Direct, Haag‐Streit Simulation, Germany) training (Heine BETA®200, Heine Optotechnik GmbH, Germany). Simulator‐based was performed groups up eight Thereafter, they underwent an objective...
Abstract Purpose To evaluate the long-term outcome of intravitreal bevacizumab in eyes with diabetic macular oedema (DME) following a PRN (pro re nata) regimen. Additionally, we investigated effect presence disorganisation retinal inner layers (DRILs) and pachychoroid (PC) at baseline on clinical outcome. Methods This retrospective study included 112 naïve DME that were followed up for 2 years. All treated six initial injections monthly intervals then received treatment according to In case...
To evaluate the impact of excimer laser-assisted deep anterior lamellar keratoplasty (Exc-DALK) and penetrating (Exc-PKP) on subfoveal choroidal thickness (SFCT) in eyes with advanced keratoconus. A retrospective comparative clinical study, which compares outcomes 24 treated Exc-DALK (G1) against matched group 43 Exc-PKP (G2) at both 2 months (T1) years (T2) postoperatively. Main included best-corrected visual acuity (BCVA), central macular (CMT), SFCT. Preoperatively, there were no...
Primary hyperoxaluria (PH1) is a group of congenital disorders characterized by increased synthesis and excretion the metabolic end product oxalate, deposition calcium oxalate (CaOx) in kidney urinary tract [1]. PH1 caused deficiency liver-specific peroxisomal enzyme alanine glyoxylate aminotransferase and, especially case PH1, renal CaOx likely to lead failure, after which combined effects failure remove it from body allow widespread throughout [2]. Retinal deposits, cause retinopathy, are...