A5056166927- Herpesvirus Infections and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Cytomegalovirus and herpesvirus research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Ocular Surface and Contact Lens
- Immune Response and Inflammation
- Corneal Surgery and Treatments
- interferon and immune responses
- Systemic Lupus Erythematosus Research
- Ocular Infections and Treatments
- Corneal surgery and disorders
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Virus-based gene therapy research
- Glaucoma and retinal disorders
- Immunodeficiency and Autoimmune Disorders
- Autoimmune and Inflammatory Disorders Research
- Animal Virus Infections Studies
- Poxvirus research and outbreaks
- Pulmonary Hypertension Research and Treatments
- NF-κB Signaling Pathways
- Retinal Diseases and Treatments
- Immune cells in cancer
- Obstructive Sleep Apnea Research
- Polyomavirus and related diseases
St. Franziskus Hospital
2015-2025
Sanofi (United States)
2016-2024
Thermo Fisher Scientific (United States)
2020
University of Duisburg-Essen
1999-2011
Archéologie des Amériques
2007
Augenstern
2003-2005
Essen University Hospital
2000-2003
Universitätsklinikum des Saarlandes
1998-2002
University of Vienna
1999
Kiel University
1997
Microglia represent the primary resident immune cells of central nervous system (CNS) and modulate local responses. Depending on their physiological functions, microglia can be classified into pro- (M1) anti-inflammatory (M2) phenotype. Interleukin (IL)-10 is an important modulator neuronal homeostasis, with neuroprotective released by microglia. Here, we investigated how IL-10 deficiency affected M1/2 polarization upon lipopolysaccharide (LPS) stimulation in vitro. phenotypes were analyzed...
The antiviral activity of acycloguanosine in vitro was compared with that idoxuridine, cytarabine, trifluorothymidine, vidarabine and phosphonoacetic acid by means plaque reduction assays VERO cells several strains type 1 2 herpes virus. dose-response lines thus obtained showed considerably more active than the other compounds. all compounds somewhat lower HeLa cells. Acycloguanosine equally effective against herpes, individual varied little their sensitivity. wider variations strain...
As part of an investigation devoted to the development new antiviral agents a compound established activity has been subjected systematic structural modification. The structure-activity data so obtained have used in design compounds, some which are described. chosen was isatin beta-thiosemicarbazone, high against neurovaccinia infection mice, and 4-point parallel-line assay vivo chemotherapeutic developed, enabled derivatives be determined beta-thiosemicarbazone as standard. overall...
In this study the retinal transcriptome was investigated during development of experimental autoimmune uveoretinitis (EAU) in mice. EAU induced by immunizing B10.RIII mice with human interphotoreceptor retinoid binding protein (hIRBP) 161–180 peptide. Genome-wide transcriptional profiles (day 7, 14 or 21 after immunization) and control retinas were generated using DNA-microarrays bioinformatic data mining. Microglia-associated transcripts identified. Quantitative real-time polymerase chain...
Methisazone (5 to 40 μM) inhibited the multiplication of types 3, 7, 9, 11, 14, 16, 17, 21, and 28 adenovirus; SV15 (a simian adenovirus) was also inhibited. A study adenovirus 11 under single-cycle conditions showed that virus completely by 30 μM methisazone when addition compound delayed until 13 hours after infection. survey structure-activity relations action against adenoviruses pox viruses are similar.
Uveitis describes a heterogeneous group of inflammatory eye diseases characterized by infiltration leukocytes into the uveal tissues. associated with HLA haplotype B27 (HLA-B27) is common subtype uveitis and prototypical ocular immune-mediated disease. Local immune mechanisms driving human are poorly mainly due to limited available biomaterial subsequent technical limitations. Here, we provide first high-resolution characterization intraocular in HLA-B27-positive (n = 4) -negative 2)...
To investigate the effect of human amniotic membrane transplantation (AMT) on T-cell immune response in murine corneas with herpetic stromal keratitis (HSK).Herpes simplex virus (HSV)-1-infected BALB/c mice necrotizing HSK were treated AMT. CD3(+) cell apoptosis was determined and vitro by flow cytometric analysis using annexin V/7-AAD system. The interleukin (IL)-2, cyclosporine, rapamycin, or Fas survival measured. Activation phenotype measured (3)H-thymidine uptake cytometry (CD25, CD69,...
Abstract The purpose of this study was to ascertain whether a correlation exists between glaucoma-associated alteration ocular vascular haemodynamics and endothelin-1 (ET-1) levels exist. Eyes patients with cataract (n = 30) or glaucoma 68) were examined optical coherence tomography (OCT) OCT-angiography (OCT-A; AngioVue™-RTVue-XR; Optovue, Fremont, California, USA). peripapillary the macular vessel density (VD) values measured. Inferior superior retinal nerve fibre layer (RNFL) thickness...