A5100757815- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Ovarian cancer diagnosis and treatment
- RNA modifications and cancer
- MicroRNA in disease regulation
- Reproductive Biology and Fertility
- Cancer, Hypoxia, and Metabolism
- Endometrial and Cervical Cancer Treatments
- Cell Adhesion Molecules Research
- Immune Cell Function and Interaction
- Endometriosis Research and Treatment
- Molecular Biology Techniques and Applications
- Circular RNAs in diseases
- Asthma and respiratory diseases
- Nanoplatforms for cancer theranostics
- Cancer-related Molecular Pathways
- Angiogenesis and VEGF in Cancer
- Pediatric health and respiratory diseases
- Respiratory and Cough-Related Research
- Pulmonary Hypertension Research and Treatments
- Sinusitis and nasal conditions
- Cancer Cells and Metastasis
- Chromosomal and Genetic Variations
- Estrogen and related hormone effects
Sanofi (United States)
2020-2024
Huazhong University of Science and Technology
2023
Obstetrics and Gynecology Hospital of Fudan University
2010-2021
Xi'an Jiaotong University
2019
Shanghai Medical College of Fudan University
2015-2019
Bethune International Peace Hospital
2019
Fudan University
2006
Periostin (POSTN) overexpression observed in various cancer types is correlated with metastasis and tumor progression. However, its effect on the crosstalk between ovarian cells cancer-associated fibroblasts (CAFs) remains elusive. This study aims to ascertain role of CAF-derived POSTN microenvironment.POSTN expression high-grade serous (HGSC) was detected through immunochemistry. Transwell assay conducted determine cell migration invasion. knocked down or overexpressed using lentiviral...
Abstract Background Deregulation of integrins signaling had been documented to participate in multiple fundamental biological processes, and the aberrant expression integrin family members were linked prognosis various cancers. However, role predicting progression ovarian cancer patients are still largely elusive. This study is aimed explore prognostic values ITGA ITGB superfamily high grade serous cancers (HGSOC). Methods GSE26712 dataset was used determine differential member between HGSOC...
Abstract We applied a combination of molecular cytogenetic methods, including comparative genomic hybridization (CGH), spectral karyotyping (SKY), and fluorescence in situ (FISH), to characterize the genetic aberrations eight widely used cervical cancer (CC) cell lines. CGH identified most frequent chromosomal losses 2q, 3p, 4q, 6q, 8p, 9p, 10p, 13q, 18q; gains 3q, 5p, 5q, 8q, 9q, 11q, 14q, 16q, 17q, 20q; high‐level amplification at 3q21, 7p11, 8q23–q24, 10q21, 11q13, 16q23–q24, 20q11.2,...
Fertility-sparing surgery for patients with borderline ovarian tumors (BOTs) is still controversial. This study aimed to evaluate the oncological safety and fertility benefits in conservative surgery,as well as efficiency of surgical procedures approaches. In total 122 BOTs, four types fertility-sparing were performed: unilateral adnexectomy (UA, n = 47), cystectomy (UC, 59), + contralateral (UA CC, 7) bilateral (BC, 9). Fifty-two (42.6 %) had undergone laparoscopy, while 70 (57.4...
This study was aimed to explore the role of long noncoding RNA C17orf91 and its potential mechanisms in ovarian cancer development. To assess cancer, microarray datasets (GSE14407, GSE30587, GSE17260) Gene Expression Omnibus (GEO) were utilized expression clinical significance cancer. Next, loss-of-function studies performed establish underlying It found that elevated observed omental metastases when compared with matched primary tumors(GSE30587, P = 0.016). Moreover, Log Rank analysis...
This study aimed to identify the different expression of microRNAs (miRNAs) in plasma derived exosomes patients with esophageal squamous cell carcinoma (ESCC).A total 9 ESCC and benign diseases were involved. miRNA sequencing was performed screen differential between controls. The function on proliferation migration abilities determined by CCK-8 analysis, wound scratch transwell test. Predicted target genes screened databases confirmed RT-qPCR.We identified a 10 miRNAs (7 upregulated 3...
2-oxoglutarate dehydrogenase (OGDH) is the first rate-limiting E1 subunit of OGDH complex (OGDHC), which plays as a regulatory point in cross-road TCA cycle and glutamine metabolism. Until now, role carcinogenesis has been unclear.In present study, we determined expression human gastric cancer (GC) tissues cell lines by RT-qPCR, Western blotting immunohistochemical staining respectively. The biological impacts on growth migration were explored through modulation GC cells. Furthermore,...
Transarterial chemoembolization (TACE) has been widely used for hepatocellular carcinoma. Reducing hypoxia in the tumor microenvironment after TACE remains a challenge as progression is common post-TACE patients due to hypoxic microenvironment. In this study, melatonin loaded on p(N-isopropyl-acrylamide-co-butyl methylacrylate) (PIB-M) was embolism. Two types of human hepatoma cell lines were explore mechanism by which prevents growth and metastasis cancer cells vitro. A VX2 rabbit model...
Accumulating evidence has indicated a large-scale regulatory network generated by 3′untranslated regions (3′UTRs) in cancer. The 3′UTRs act not only cis but, most likely even more importantly, as trans regulators of gene expression, consequently leading to phenotypic alterations. Here, we found that ectopic expression SNAI1 3′UTR induced migration and invasion ovarian cancer cell line RMUG-L without significantly affecting viability. Additionally, overexpression regulated key...
Cervical cancer is one of the most common tumor affecting women worldwide. Human papillomavirus (HPV) was found to have a causal relationship with cervical and its precursors. The interaction between HPV E6 protein p53 identified in vitro studies. aim study evaluate prevalence alterations related infection prognostic significance cancer. Studies were by MEDLINE search, all relevant articles retrieved from 1991 March 2004. mutations rare event correlation or prognosis controversial. Loss...
To investigate the clinicopathologic characteristic and fertility results of patients with mucinous borderline ovarian tumors (MBOTs), effects intraepithelial carcinoma (IECA) on them.Fifty-two treated for MBOTs or without IECA were retrospectively analyzed.Patients more frequently observed at stage Ic (3/12 vs 1/40, P = 0.034) accompanied by microinvasive 0.034). The detected rate intraoperative frozen section (5/12, 41.7%) was much lower than that (82.5%, 0.010). About 61.5% in our study...
Abstract Background Lymphovascular space invasion (LVSI) is the first step of hematogenous metastasis. Exploration differential miRNA expression profiles between LVSI-positive and LVSI-negative ovarian cancer tissues may help to identify key miRNAs involved in metastasis cancer. This study aimed microRNAs (miRNAs) that are differentially expressed tissues, followed by exploring their association with bevacizumab response patients. Methods The Cancer Genome Altas (TGGA) dataset was used...
Objective: Recently, accumulating evidence has indicated that the 3' untranslated regions (3'UTRs) of protein coding genes play critical roles in progression various cancers, including ovarian cancer. This study is aimed to identify potential role SNAI2-3'UTR ovarain cancer progression. Study Design: First, we tried explore clinical significance SNAI2 using TCGA and GSE26712 dataset. Then, gain-of-function studies were performed establish invasion migration cells. Finally, efforts made...
<h3>Purpose</h3> Clinical phenotypes of chronic obstructive pulmonary disease (COPD) include bronchitis and emphysema, which have a high degree overlap. In the phase 3 BOREAS (NCT03930732) trial, add-on dupilumab vs placebo significantly reduced rate moderate or severe exacerbations improved lung function, health-related quality life, symptoms in patients who had COPD, type 2 inflammation, an elevated exacerbation risk despite inhaled triple therapy. This analysis assessed annualized rates...
Patients with chronic rhinosinusitis nasal polyps (CRSwNP) and comorbid nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (NSAID-ERD) often have more severe than patients without NSAID-ERD. Dupilumab is a fully human monoclonal antibody that blocks the shared receptor component for interleukin (IL)-4 IL-13, key drivers of type 2 inflammation in multiple diseases. We aimed to assess effect dupilumab vs placebo on upper lower airway outcome measures CRSwNP NSAID-ERD...
Serum tumor biomarkers are significant for the early diagnosis and treatment,preoperative evaluation,prognosis prediction relapse surveillance of endometrial carcinoma.Recently,serum CA125 human epididymal secretory protein 4 widely recognized as closely related with staging,metastasis prognosis cancer.In addition,the serum miRNAs characterized by their features high stability specificity.Omics studies will be helpful general assessment initiation progression cancer.Insights into these two...