A5023586164- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Respiratory Support and Mechanisms
- IL-33, ST2, and ILC Pathways
- Pediatric health and respiratory diseases
- Air Quality and Health Impacts
- COVID-19 Clinical Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Energy and Environment Impacts
- Pharmacological Effects of Natural Compounds
- Mycobacterium research and diagnosis
- Genomics and Phylogenetic Studies
- Allergic Rhinitis and Sensitization
- Diverse Scientific Research Studies
- Psychosomatic Disorders and Their Treatments
- Cardiac Arrhythmias and Treatments
- Restraint-Related Deaths
- Obstructive Sleep Apnea Research
- Soft tissue tumors and treatment
- Tumors and Oncological Cases
- Gut microbiota and health
- Health, psychology, and well-being
- Phagocytosis and Immune Regulation
Sharda University
2021-2025
University of Manchester
2012-2024
Medicines Evaluation Unit
2005-2024
Manchester University NHS Foundation Trust
2019-2024
James Cook University Hospital
2023
ICAR-Indian Institute of Agricultural Biotechnology
2021-2022
Community Medical Center
2021
Vinoba Bhave University
2021
National Dairy Research Institute
2021
Manchester Academic Health Science Centre
2015-2020
CRTH2 (chemoattractant receptor expressed on T-helper (Th) type 2 cells) is a G-protein-coupled by Th2 lymphocytes and eosinophils that mediates prostaglandin (PG)D<sub>2</sub>-driven chemotaxis. We studied the efficacy of oral antagonist OC000459 in steroid-naïve asthmatic patients. A randomised, double-blind, placebo-controlled, two-way crossover study 16 days’ treatment with (200 mg twice daily) late (LAR) early (EAR) responses to bronchial allergen challenge was conducted, subjects...
Increasingly, exhaled breath condensate (EBC) is being used to sample airway fluid from the lower respiratory tract. EBC pH may be a biomarker of inflammation in chronic obstructive pulmonary disease (COPD). In this study, reproducibility COPD was investigated. A total 36 patients and 12 healthy nonsmoking subjects participated several investigations: duration argon deaeration, within-sample variability, effect freezing, leaving samples at room temperature, nose-peg use, within- (WD)...
Chronic Obstructive Pulmonary Disease (COPD) is a common health issue globally and expected to increase in the future. The latest Global Initiative for COPD (GOLD) guidelines describe various phenotypes of COPD. This study assessed different clinical disease-specific health-related quality life (HRQoL) patients with A hospital-based cohort was conducted among phenotypes. All were evaluated through detailed history, examination, complete blood count, electrocardiogram (ECG) fulfill inclusion...
Examination of samples stool from a 61-year-old male patient, presenting with the clinical symptoms Crohn's disease (CD), revealed massive shedding acid fast bacilli morphology Mycobacterium avium paratuberculosis (MAP), causative agent Johne's in cattle. MAP was cultured stool. Biotyping bacterium isolated cultures demonstrated, it Indian Bison biotype MAP, dominant infecting livestock and humans India. Based on this finding because patient unresponsive to standard therapy used India treat...
Jack (Artocarpus heterophyllus) is a multi-purpose out-breeding tree species of the family Moraceae. We generated 42,928,887 high-quality expressed sequence reads, assembled them into 89,356 unigenes, and discovered 16,853 unigene-based perfect SSRs in A. heterophyllus. Thirty-eight polymorphic were used to analyze genetic diversity population structure 224 germplasm accessions heterophyllus constituting three populations from agro-climatic zones, namely Eastern Plateau Hills, Middle...
A 66-year-old man with Stage IIb pancreatic cancer and atrial fibrillation (AF) was admitted for chemotherapy.He not on any rate-control drugs noted to be bradycardic routine parameter monitoring.Electrocardiography (ECG) performed (Fig. 1).What is the ECG diagnosis?
Jack (Artocarpus heterophyllus) is a multipurpose fruit-tree species with minimal genomic resources. The study reports developing comprehensive transcriptome data containing 80,411 unigenes an N50 value of 1265 bp. We predicted 64,215 CDSs from the and annotated functionally categorized them into biological process (23,230), molecular function (27,149), cellular components (17,284). From unigenes, we discovered 16,853 perfect SSRs 192 distinct repeat motif types reiterating 4 to 22 times....
Background: Air pollution is one of the world's most serious environmental problems. has many negative health effects on general population, especially children, individuals with underlying chronic disease, and elderly. The aims this study were to evaluate traffic-related exacerbation asthma development respiratory infections in schoolgoing children Agra, suffering from compared healthy subjects, estimate association between incremental increases principal pollutants incidence...
<h3>Purpose</h3> Clinical phenotypes of chronic obstructive pulmonary disease (COPD) include bronchitis and emphysema, which have a high degree overlap. In the phase 3 BOREAS (NCT03930732) trial, add-on dupilumab vs placebo significantly reduced rate moderate or severe exacerbations improved lung function, health-related quality life, symptoms in patients who had COPD, type 2 inflammation, an elevated exacerbation risk despite inhaled triple therapy. This analysis assessed annualized rates...
<h3>Introduction</h3> FRONTIER-4 (NCT04631016) examined the effect of tozorakimab on lung function in COPD patients with chronic bronchitis dual- or triple-inhaled maintenance therapy. <h3>Methods</h3> Patients were randomized 1:1 to receive 600 mg placebo (PBO) s.c. Q4W. The primary endpoint was change pre-BD FEV<sub>1</sub> from baseline week 12. Secondary outcomes included post-BD FEV<sub>1</sub>, time-to-first COPDCompEx event and safety. <h3>Results</h3> ITT population 135 (tozorakimab,...
<h3>Introduction</h3> Mucus plugging in COPD is associated with airflow obstruction, poor health-related quality of life and high all-cause mortality. Preclinical studies have shown that tozorakimab reduces mucus hypersecretion cultured epithelial cells. <h3>Objective</h3> Assess the impact on plugs using computed tomography (CT) imaging. <h3>Methods</h3> The FRONTIER-4 phase 2 study (NCT04631016) investigated patients chronic bronchitis dual- or triple-inhaled maintenance therapy. Patients...
<h3>Introduction</h3> Patients with type 2 inflammation in COPD suffer from frequent exacerbations and high symptom burden. Dupilumab, a fully human monoclonal antibody, blocks the shared receptor component of interleukin (IL)-4 IL-13, key central drivers inflammation. The second pivotal phase 3 NOTUS (NCT04456673) trial aimed to evaluate efficacy safety dupilumab patients <h3>Methods</h3> was 52-week 3, randomized, double-blind, placebo-controlled subcutaneous add-on 300 mg q2w or placebo....
<h3>Introduction and Objectives</h3> Dupilumab, a fully human monoclonal antibody that blocks the shared receptor component for IL-4 IL-13, lowered exacerbation frequency improved health-related quality of life respiratory symptoms in phase 3 BOREAS (NCT03930732). Herein, we evaluated whether dupilumab results an improvement daily symptom burden using Evaluating Respiratory Symptoms COPD (E-RS<sup>TM</sup>:COPD) tool patients who did not experience ('non-exacerbators'). <h3>Methods</h3> In...
Asthma is a chronic inflammatory condition, which associated with increase in airway hyper responsiveness that leads to recurrent episodes of wheezing, breathlessness, chest tightness and coughing. very common respiratory illness, some the disease related factors may increases vulnerability psychiatric disorders. This study was done determine prevalence co-morbidity patients bronchial asthma.It an observational conducted 110 follow-up asthma attending medicine OPD at tertiary care centre...
Any type of contact with electricity low or high voltage can cause injury to the human body a variable effect on body. Low-voltage is quite common worldwide, there very less information present in available literature. The degree organ damage depends many factors, which include duration electric current exposure, type, and nature affected tissue. most presentations are muscle injury, hyperkalemia, pulmonary oedema, rarely isolated diffuse haemorrhage. We case bilateral haemorrhage due shock...
<h3>Rationale</h3> Chronic obstructive pulmonary disease (COPD) is characterized by progressive lung function decline and worsening symptoms, accelerated recurrent exacerbations. Type 2 (T2) inflammation may play a significant role in subset of patients with COPD. Dupilumab, fully human monoclonal antibody, blocks the shared receptor component for interleukin (IL)-4 IL-13, key central drivers T2 inflammation. <h3>Methods</h3> BOREAS (NCT03930732) was 52-week, phase 3, placebo-controlled...
Though, smoking is the leading cause of chronic obstructive pulmonary disease worldwide, household air pollution due to use solid biomass fuel considered as a major risk factor for development lung disease. The aim study was assess effect exposure on functions in non-smoking female population.A hospital based, descriptive cross sectional carried out among 140 patients aged 40 or more and who had been exposed fuel. These underwent spirometry their function were classified obstructive,...
Background: Coronavirus disease-2019 (COVID-19) is a recently emerged viral disease, for which there’s currently no definitive treatment. It is, therefore, necessary to determine biomarkers know the extent of disease severity so that timely action can be taken reduce mortality. We aimed usefulness C-reactive protein (CRP) levels in assessing COVID-19 and correlate them with mortality due same. Methods: Data were retrospectively collected analyzed from May 2020 October 2020. The CRP value was...