A5048967666- Ocular Diseases and Behçet’s Syndrome
- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- Retinal and Optic Conditions
- interferon and immune responses
- Ocular Infections and Treatments
- Inflammasome and immune disorders
- Glaucoma and retinal disorders
- Spondyloarthritis Studies and Treatments
- Vasculitis and related conditions
- Cytomegalovirus and herpesvirus research
- Retinal Diseases and Treatments
- Bartonella species infections research
- Otitis Media and Relapsing Polychondritis
- Nephrotoxicity and Medicinal Plants
- Bone and Joint Diseases
- Ocular Surface and Contact Lens
- Corneal surgery and disorders
- Neonatal Health and Biochemistry
- melanin and skin pigmentation
- Herpesvirus Infections and Treatments
- Ophthalmology and Visual Health Research
- Sarcoidosis and Beryllium Toxicity Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- IgG4-Related and Inflammatory Diseases
St. Franziskus Hospital
2016-2025
University of Duisburg-Essen
2017-2024
Universitätsklinik für Augenheilkunde
2020
Ophthalmology Clinic
2020
Essen University Hospital
2019-2020
University Hospital Münster
2015
In 2012, a European initiative called Single Hub and Access point for pediatric Rheumatology in Europe (SHARE) was launched to optimise disseminate diagnostic management regimens children young adults with rheumatic diseases. Juvenile idiopathic arthritis (JIA) is the most common disease uveitis possibly its devastating extra-articular manifestation. Evidence-based guidelines are sparse mostly based on physicians' experience. Consequently, treatment practices differ widely, within between...
Purpose: Juvenile idiopathic arthritis-associated uveitis (JIAU) is the most common entity in childhood. As S100A8/A9 and S100A12 proteins are valuable biomarkers childhood arthritis, we investigated occurrence of these uveitis. Methods: Serum samples from patients with JIAU (n = 79) or anterior (IAU, n 24), as well nonuveitic controls were collected. Furthermore, aqueous humor (JIAU 17, 16, IAU 12) obtained. Samples analyzed for protein levels by ELISA. Intergroup comparisons performed,...
To analyze the prognostic value of demographic, clinical, and therapeutic factors laboratory biomarkers to assess their role in predicting uveitis occurrence patients with juvenile idiopathic arthritis (JIA).Patients JIA were enrolled within first year after diagnosis. Demographic clinical parameters documented. Serum samples collected at study enrollment, 3-month follow-up visits year, then every 6 months. A multivariable Cox regression analysis was performed evaluate impact laboratory, on...
Juvenile idiopathic arthritis-associated uveitis (JIAU) typically takes a chronic course, frequently leading to ocular complications and often requiring long-term treatment. The present study assesses the 5-years outcome of JIAU by analyzing data from prospective initiated in 2010. Data 75 patients with onset after enrollment, documentation at follow-up (5yFU) were available for analysis characteristics, frequency predictors "inactivity on medication " (defined as inactive ≥ 6 months) off...
To define predictors for the 2-year outcome in terms of achieving inactivity, subsequent uveitis reactivation and occurrence uveitis-related complications JIA-associated uveitis.Demographic clinical parameters serum samples patients enrolled ICON at ⩽1 year JIA diagnosis were collected study enrolment, every 3 months during first subsequently 6 months. Predictors evaluated by linear mixed models.Of 954 included, occurred 106 up to follow-up, with 98 them having complete ophthalmological...
Uveitis describes a heterogeneous group of inflammatory eye diseases characterized by infiltration leukocytes into the uveal tissues. associated with HLA haplotype B27 (HLA-B27) is common subtype uveitis and prototypical ocular immune-mediated disease. Local immune mechanisms driving human are poorly mainly due to limited available biomaterial subsequent technical limitations. Here, we provide first high-resolution characterization intraocular in HLA-B27-positive (n = 4) -negative 2)...
Purpose.: The pathogenesis of juvenile idiopathic arthritis-associated uveitis (JIAU) is undefined. This study intended to analyze the presence antiocular autoantibodies in serum and their correlation with disease course. Methods.: Serum samples from children JIAU (n = 47); JIA without 67); anterior (IAU; n 12); healthy controls 52) were collected. binding patterns antibodies ocular cryosections swine eyes analyzed by indirect immunohistochemistry, correlated epidemiological, clinical,...
Patients with juvenile idiopathic arthritis often develop chronic anterior uveitis (JIAU). JIAU patients possess a particularly high risk for developing secondary glaucoma when inflammatory inactivity has been achieved. By using multiplex bead assay analysis, we assessed levels of pro- and anti-inflammatory cytokines, chemokines, or metalloproteinases in the aqueous humor (AH) clinically inactive (JIAUwG) without (JIAUwoG), from senile cataract as controls. Laser-flare photometry analysis...
Objective. Enthesitis-related arthritis (ERA) represents a subgroup of juvenile idiopathic (JIA) that is regularly accompanied by anterior uveitis. This study describes the prevalence and characteristics ERA-related Methods. Cross-sectional data from National Pediatric Rheumatological Database (NPRD) were used to characterize uveitis (ERA-U). In addition sociodemographic variables, we documented occurrence course disease, including symptoms, visual acuity, complications, as well JIA such...
Objective Several case reports have been published on the effect of janus kinase inhibitors (JAK-I) juvenile idiopathic arthritis-associated uveitis (JIAU). Both tofacitinib and baricitinib described as therapeutically effective in JIAU.Methods We here present a 24-years-old female with refractory course JIAU receiving upadacitinib therapy.Results After failing multiple conventional biologic disease-modifying antirheumatic drugs, patient finally achieved clinical remission monotherapy,...
To analyze the binding patterns of serum autoantibodies from juvenile idiopathic arthritis (JIA) and JIA-associated uveitis (JIAU) patients to proteomes different ocular tissues identify potential autoantigens in JIAU. Proteomes porcine iris, ciliary body, or retina tissue were isolated, separated using 2D-gel electrophoresis, transferred a blotting membrane. The pattern antibodies JIA JIAU healthy controls proteins was visualized by anti-human IgG secondary chemiluminescence reaction....
Zusammenfassung Okuläre Manifestationen rheumatischer Erkrankungen sind häufig und tragen wesentlich zur Morbidität Reduktion der Lebensqualität betroffenen Patienten bei. Die Kenntnis über typische Manifestationsformen ist bedeutsam für den Rheumatologen, um mit entsprechender Symptomatik frühzeitig ophthalmologisch vorstellen zu können oder auch regelmäßige Screeninguntersuchungen veranlassen (z. B. bei Behçet-Syndrom). Umgekehrt eine (ggf. dringliche) rheumatologische Mitbeurteilung...
Zusammenfassung Bei der peripheren ulzerativen Keratitis (PUK) handelt es sich um eine entzündliche Erkrankung Hornhaut, die in vielen Fällen mit seltenen, aber potenziell lebensbedrohlichen systemischen Autoimmunerkrankungen assoziiert sein kann. Die Pathogenese PUK beruht auf einer humoralen sowie zellulär vermittelten Inflammation. Diagnosestellung erfolgt i. d. R. anhand des typischen klinischen Befunds und erfordert stets ausführliche Diagnostik zur Identifizierung potenziellen...
HLA-B27 is the allele most frequently associated with human anterior uveitis. The majority of HLA-B27-positive (acute uveitis, AAU) patients develop clinically distinct symptoms acute symptomatic onset flare and a recurrent disease course characterized by massive cellular ocular infiltrate during uveitis relapse. In contrast, in HLA-B27-negative (idiopathic IAU) tends to less fulminant, more chronic typically asymptomatic course. order analyze systemic immune responses different entities, we...
D. Bauer PhD1** , M. Kasper PhD1* K. Walscheid MD1, J. Koch P. S. Müther MD2, B. Kirchhof A. Heiligenhaus MD13 & C. Heinz 1 Department of Ophthalmology and Ophtha-Lab, St. Franziskus Hospital Münster, Germany2 Center for Ophthalmology, University Cologne, Köln, Germany3 Duisburg-Essen, Essen, Germany
Purpose: To analyze circulating immune cells in patients with anterior uveitis (AU) associated to axial spondyloarthritis (SpA), or juvenile idiopathic arthritis (JIA).Methods: Venous blood samples were collected from healthy controls (n = 16), and either SpA 19) JIA 23) during active flare, after ≥3 months of inactivity. Frequencies CD56+, MHC-I+, S100A9+ monocytes, CCR7+ dendritic cells, CD56+dim natural killer (NK) CD3+CD56bright T-cells analyzed via flow cytometry. Serum S100A8/A9 levels...
Objective. Data on uveitis in juvenile psoriatic arthritis (JPsA), a category of idiopathic (JIA), are scarce. We describe prevalence and risk factors for JPsA-associated (JPsA-U). Methods. Cross-sectional data from the German National Pediatric Rheumatological Database (2002–2014) were used to characterize JPsA-U assess development uveitis. Results. Uveitis developed 6.6% 1862 patients with JPsA. Patients more frequently female (73.0 vs 62.9%, P = 0.03), antinuclear antibody (ANA) positive...
Zusammenfassung Eine häufige Komplikation bei Uveitis ist die Katarakt, deren Management anspruchsvoll sein kann. Die Operationsplanung setzt eine Kenntnis von Ursache (z. B. infektiös versus nichtinfektiös) und Verlauf der voraus, einschließlich aller intraokularen Komorbiditäten Makulaödem). präoperative Patientenselektion Uveitispatienten zum Erzielen guter Operationsergebnisse besonders bedeutsam. Mit steroidsparenden krankheitsmodifizierenden antirheumatischen Medikamenten (DMARDs) kann...