A5023536826- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Systemic Lupus Erythematosus Research
- Retinal Diseases and Treatments
- Vasculitis and related conditions
- Glaucoma and retinal disorders
- Ocular Infections and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Cytomegalovirus and herpesvirus research
- Lymphoma Diagnosis and Treatment
- Otitis Media and Relapsing Polychondritis
- CNS Lymphoma Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Cerebral Venous Sinus Thrombosis
- Ocular Surface and Contact Lens
- interferon and immune responses
- Intraocular Surgery and Lenses
- Retinal Development and Disorders
- Traumatic Ocular and Foreign Body Injuries
- Antifungal resistance and susceptibility
- Retinal Imaging and Analysis
- Ocular Oncology and Treatments
- Syphilis Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Vascular Tumors and Angiosarcomas
Jichi Medical University
2020-2025
Jichi Medical University Saitama Medical Center
2020-2025
Saitama Prefecture
2021-2024
University of Tokyo Hospital
2015-2024
The University of Tokyo
2014-2023
Keio University
2023
Public interest incorporated foundation Keep Association
2023
National Defense Medical College
2018
Data Management (Italy)
2018
Bunkyo University
2018
Aims International criteria for the diagnosis of ocular sarcoidosis (OS) was established by first Workshop on Ocular Sarcoidosis (IWOS) and validations studies revealed certain limitations criteria. To overcome limitations, revised IWOS in an international meeting. This manuscript aimed at reporting Methods A consensus workshop carried out to discuss revise The held 27 April 2017, Nusa Dua, Bali, Indonesia. Prior workshop, a questionnaire proposing consisting one item differential diagnosis,...
An international, expert-led consensus initiative to develop systematic, evidence-based recommendations for the treatment of noninfectious uveitis in era biologics.The availability biologic agents human eye disease has altered practice patterns management uveitis. Current guidelines are insufficient assure optimal use noncorticosteroid systemic immunomodulatory agents.An international expert steering committee comprising 9 specialists (including both ophthalmologists and rheumatologists)...
To evaluate safety and efficacy of adalimumab in patients with noninfectious intermediate, posterior, or panuveitis.Phase 3, open-label, multicenter clinical trial extension (VISUAL III).Adults meeting treatment failure (TF) criteria who completed VISUAL I II (phase randomized, double-masked, placebo-controlled) without TF.Patients received 40 mg every other week. Interim follow-up data were described from III weeks 0 through 78.Disease quiescence, steroid-free active inflammatory...
Abstract Eighty Japanese children, aged 8–12 years, with a spherical equivalent refraction (SER) of − 1.00 to 6.00 dioptres (D) were randomly allocated into two groups receive either combination orthokeratology (OK) and 0.01% atropine solution (combination group) or monotherapy OK (monotherapy group). Seventy-three subjects completed the 2-year study. Over 2 axial length increased by 0.29 ± 0.20 mm ( n = 38) 0.40 0.23 35) in groups, respectively P 0.03). Interactions between treatment age...
Although intraocular pressure (IOP) is the most definitive cause of glaucoma, a subtype open angle glaucoma (OAG) termed normal tension (NTG), which occurs in spite IOP, accounts for large part cases, especially Japan. To find common genetic variants contributing to NTG Japanese patients, we conducted genome-wide association study (GWAS). We performed first screening 531,009 autosomal SNPs with discovery cohort 286 cases and 557 controls, then second top 30 suggestive loci an independent 183...
PurposeTo evaluate long-term efficacy and safety of extended treatment with adalimumab in patients noninfectious intermediate, posterior, or panuveitis.DesignOpen-label, multicenter, phase 3 extension study (VISUAL III).ParticipantsAdults who had completed a randomized, placebo-controlled parent trial I II) without failure (inactive uveitis) discontinued the after meeting criteria (active uveitis).MethodsPatients received subcutaneous 40 mg every other week. Data were collected for ≤ 362...
Sarcoidosis is a heterogeneous and multisystem granulomatous disorder. The etiology still uncertain, but the disease currently thought to be triggered by various genetic as well environmental factors. Recently, an association between sarcoidosis butyrophilin-like 2 (BTNL2) gene located in close proximity HLA-DRB1 was reported. purpose of our study verify relationship BTNL2 HLA risk alleles for susceptibility sarcoidosis, assess whether independent alleles.In study, 11 single nucleotide...
The distribution of uveitis varies with genetic, ethnic, geographic, environmental, and lifestyle factors. Epidemiological information about the patterns is useful when an ophthalmologist considers diagnosis uveitis. Therefore, it important to identify causes over years in different regions. purposes this study were characterize patients who first arrived at University Tokyo Hospital 2013–2015, analyze changes from 2004 2012 2013–2015. We retrospectively identified 750 newly visited Uveitis...
Abstract The purpose of this study is to examine if aqueous autotaxin (ATX) and TGF-β levels could be used for differentiating glaucoma subtypes. This prospective observational was performed using humor samples obtained from 281 consecutive patients. Open angle patients were classified into three groups: primary open-angle (POAG), secondary (SOAG), exfoliation (XFG). Aqueous ATX TGF-βs quantified. AUC as well sensitivity specificity the classification normal subtypes four indicators-ATX,...
Lymphomatoid granulomatosis (LYG) is a rare B-cell lymphoproliferative disorder predominantly affecting middle-aged men. The disease occurs primarily in the lungs; however, reports of lesions intraocular regions are scarce. Herein, we report case choroidal granulomas patient with LYG. A 55-year-old male presented to respiratory specialist pneumonia unknown cause. His serum-soluble IL-2 receptor level was highly elevated, and transbronchial lung biopsies revealed granulomatous lesions....
Abstract Treatment of uveitis is complicated because its multiple aetiologies and elevation various inflammatory mediators. To determine the mediators that are elevated in vitreous humor according to aetiology uveitis, we examined concentrations 21 cytokines, 7 chemokines, 5 colony-stimulating/growth factors samples from 57 eyes with associated intraocular lymphoma (IOL, n = 13), sarcoidosis (n 15), acute retinal necrosis (ARN, or bacterial endophthalmitis (BE, 16). Samples idiopathic...
Objective Behçet’s disease is a complex systemic inflammatory vasculitis of incompletely understood etiology. This study was undertaken to investigate genetic associations with in diverse multiethnic population. Methods A total 9,444 patients and controls from 7 different populations were included this study. Genotyping performed using an Infinium ImmunoArray‐24 v.1.0 or v.2.0 BeadChip. Analysis expression data stimulated monocytes, epigenetic chromatin interaction analyses performed....