A5102892522- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Systemic Lupus Erythematosus Research
- Catalytic C–H Functionalization Methods
- Catalytic Alkyne Reactions
- Vasculitis and related conditions
- Retinal Diseases and Treatments
- Lymphoma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Analytical Chemistry and Chromatography
- HIV Research and Treatment
- Cyclopropane Reaction Mechanisms
- Antibiotic Resistance in Bacteria
- Organic Chemistry Cycloaddition Reactions
- HIV/AIDS drug development and treatment
- Synthetic Organic Chemistry Methods
- Enzyme Catalysis and Immobilization
- Cancer Research and Treatments
- Traditional Chinese Medicine Analysis
- Natural product bioactivities and synthesis
- Protease and Inhibitor Mechanisms
- Catalytic Cross-Coupling Reactions
- Ocular Infections and Treatments
- Insect Resistance and Genetics
- Otitis Media and Relapsing Polychondritis
University of Tokyo Hospital
2015-2025
Saitama Municipal Hospital
2025
National Hospital Organization Saitama Hospital
2025
Saiseikai Ibaraki Hospital
2022
Osaka Kaisei Hospital
2022
The University of Tokyo
1999-2021
Japan Women's University
2019
Numazu City Hospital
2019
Aichi Cancer Center
1988-2018
Seitoku University
2017
To examine the recurrence of cytomegalovirus (CMV) iritis in patients using low-dose ganciclovir (GCV) eye drops. We included with dormant CMV who were treated 2% GCV drops at University Tokyo Hospital between January and June 2023 whose dosage was required to be reduced due unstable supply. Patients excluded if they had active retinitis underwent corneal transplantation. examined after reduction Fifteen eyes 14 (mean age, 62.4 ± 13.0 years) included. The frequency from four times a day...
Summary Primary intraocular lymphoma ( IOL ) has a propensity for central nervous system CNS relapse within 2 years of initial diagnosis, affecting clinical outcome. To reduce relapse, we performed the combination treatment protocols intravitreal methotrexate injections, methotrexate‐based systemic induction chemotherapy and consolidation high‐dose cytarabine reduced‐dose whole brain radiation therapy (rd WBRT , 23·4 Gy) B‐cell primary with or without newly diagnosed involvement. All...
Background: Five HIV-2-seropositive cases were recently identified in Japan, outside the HIV-2 endemic area of West Africa. To clarify molecular epidemiology we analyzed sequences these detail. Methods: genetic groups determined by gag and env sequences. For suspected recombinant isolates, structure was full-length genomic analyses. understand history evolution estimated time most recent common ancestor Bayesian Markov chain Monte Carlo method. Results: Three isolates as recombinants A B,...
The distribution of uveitis varies with genetic, ethnic, geographic, environmental, and lifestyle factors. Epidemiological information about the patterns is useful when an ophthalmologist considers diagnosis uveitis. Therefore, it important to identify causes over years in different regions. purposes this study were characterize patients who first arrived at University Tokyo Hospital 2013–2015, analyze changes from 2004 2012 2013–2015. We retrospectively identified 750 newly visited Uveitis...
Background: Use of antiretroviral drugs has reduced the mortality rate for HIV infection and many HIV-discordant couples wish to have children. It is possible an HIV-infected man father children without risk transmission if HIV-free spermatozoa can be obtained from his semen. Methods: An improved swim-up method was used collect semen HIV-positive males. Diluted layered over a Percoll solution with continuous density gradient 30–98%, then centrifuged. The bottom layer collected by cutting end...
Thioredoxins (Trxs) are important regulators of photosynthetic fixation CO(2) and nitrogen in plant chloroplasts. To date, they have been considered to play a minor role controlling the Calvin cycle marine diatoms, aquatic primary producers, although diatoms possess set plastidic Trxs. In this study we examined influences redox state involvement Trxs enzymatic activities pyrenoidal carbonic anhydrases, PtCA1 PtCA2, diatom Phaeodactylum tricornutum. The recombinant mature -2 (mPtCA1 -2) were...
Abstract Treatment of uveitis is complicated because its multiple aetiologies and elevation various inflammatory mediators. To determine the mediators that are elevated in vitreous humor according to aetiology uveitis, we examined concentrations 21 cytokines, 7 chemokines, 5 colony-stimulating/growth factors samples from 57 eyes with associated intraocular lymphoma (IOL, n = 13), sarcoidosis (n 15), acute retinal necrosis (ARN, or bacterial endophthalmitis (BE, 16). Samples idiopathic...
Shoot primordia, which were able to propagate vegetatively with a very high rate and redifferentiate easily new plants, induced from shoot tips of Stevia rebaudiana Bertoni on Gamborg B5 medium containing 6-benzylaminopurine (BAP) alpha-naphthaleneacetic acid (NAA) under light. The propagation the primordia is rapid, they are highly stable in chromosome number karyotype. can at for long time without differentiation. At any time, readily developed into plantlets shoots roots within 2 or 3...
Abstract We have established that a cationic rhodium(I)/H 8 ‐binap complex catalyzes [2+2+2] cycloadditions of variety 1,6‐ and 1,7‐diynes with both electron‐deficient electron‐rich carbonyl compounds, leading to dienones in high yield under mild reaction conditions. In the reactions acyl phosphonates, reactivity was highly dependent on their own structures. The addition chelating diethyl oxalate effectively promoted involving presumably due equilibrium formation desired 1:1 rhodium diyne...
To investigate the frequency of conditions newly arrived patients with uveitis from 2010 to 2012 and compare this that since 2004.We retrospectively analyzed clinical records who visited outpatient clinic January December 2012, compared them those 2004-2009.From 695 new Tokyo University Hospital, a definite diagnosis made in 431 (62.0%). The most common was scleritis (8.3%), followed by sarcoidosis (8.1%); herpetic iridocyclitis (5.5%); Behçet disease (4.6%); Vogt-Koyanagi-Harada (4.0%);...
Purpose To establish diagnostic criteria for vitreoretinal lymphoma (VRL) using cytology and laboratory tests from vitreous samples: interleukin (IL)-10/IL-6 ratio, immunoglobulin (Ig) H gene rearrangement, clonal B-cells on flow cytometry.Methods Fifty-six patients with 39 without VRL were included. We assessed the sensitivity specificity of each test those based combinations these tests.Results The values malignant cytology, IL-10/IL-6 > 1, IgH cytometry 0.554, 0.821, 0.732, 0.625 1.000,...
To the Editors: Echovirus 11 (E-11) is a single-stranded RNA virus from genus Enterovirus within family Picornaviridae. Like other enteroviruses, E-11 infections can range mild nonspecific symptoms to severe neurological disorders, including meningitis and encephalitis.1 Between July 2022 April 2023, 9 neonates 3 regions in France were hospitalized pediatric intensive care units for suspected neonatal sepsis caused by E-11.2 All cases developed acute hepatocellular failure with cytolysis...
We have established that a cationic rhodium(I)/H(8)-BINAP complex catalyzes the asymmetric reductive cyclization of heteroatom-linked 5-alkynals with heteroatom-substituted acetaldehydes in good yields outstanding enantioselectivity.
We examined the subtype-selective binding site of β-adrenergic receptors (βARs). The β<sub>1</sub>/β<sub>2</sub>-chimeric showed importance second and seventh transmembrane domains (TM2 TM7) β<sub>2</sub>AR for β<sub>2</sub>-selective agonists such as formoterol procaterol. Alanine-substituted mutants TM7 that Tyr<sup>308,</sup> located at top TM7, mainly contributed to β<sub>2</sub> selectivity. However, Tyr<sup>308</sup> interacted with procaterol in two different ways. results Ala-...