A5067696066- Ocular Diseases and Behçet’s Syndrome
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Systemic Lupus Erythematosus Research
- Retinal Imaging and Analysis
- Cytomegalovirus and herpesvirus research
- Ocular Surface and Contact Lens
- interferon and immune responses
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Vitamin K Research Studies
- Sarcoidosis and Beryllium Toxicity Research
- Vasculitis and related conditions
- COVID-19 Clinical Research Studies
- Ocular Infections and Treatments
- Immune Response and Inflammation
- Otitis Media and Relapsing Polychondritis
- Intraocular Surgery and Lenses
- Retinal and Macular Surgery
- SARS-CoV-2 and COVID-19 Research
- Adenosine and Purinergic Signaling
- Ocular Oncology and Treatments
- Retinal Development and Disorders
- Pharmacological Effects of Natural Compounds
Jichi Medical University
2016-2025
Japan Organization of Occupational Health and Safety
2021-2025
Kansai Rosai Hospital
2023-2024
Fukuoka University
2021
Kanazawa University
2020
Yokohama Rosai Hospital
2020
Jichi Medical University Hospital
1997-2019
Japanese Red Cross Kumamoto Hospital
2007-2014
Saitama Red Cross Hospital
2004-2012
The University of Tokyo
1990-2011
Disease staging involves the assessment of disease severity or progression and is used for treatment selection. In diabetic retinopathy, using a wide area more desirable than that limited area. We investigated if deep learning artificial intelligence (AI) could be to grade retinopathy determine prognosis.The retrospective study analyzed 9,939 posterior pole photographs 2,740 patients with diabetes. Nonmydriatic 45° field color fundus were taken four fields in each eye annually at Jichi...
Background. The expression of Fas ligand (FasL) in the eye has been proposed to be an important component ocular immune privilege. Since unusually favorable outcome corneal transplantation is thought result from privilege eye, examination function FasL on allografts would a test that hypothesis. Methods. To investigate role Fas-FasL interaction allografts, orthotopic was performed using C57BL/6(B6, FasL+) and B6-gld (FasL-) mice as cornea donors BALB/c recipients. rejection rate grafts...
The aim of this study was to investigate the safety and efficacy a single injection intravitreal faricimab (IVF) in patients with neovascular age-related macular degeneration (nAMD) who had prior treatment history.A retrospective analysis conducted on consecutive cohort 80 eyes 75 nAMD history an anti-vascular endothelial growth factor. Best-corrected visual acuity (BCVA), central subfield thickness (CST), choroidal (CCT) were compared before initial IVF after interval matching previous...
Purpose: To identify factors associated with intraocular inflammation (IOI) in patients neovascular age-related macular degeneration (nAMD) treated brolucizumab. Methods: In this prospective observational study, we collected aqueous humor samples from 96 eyes of receiving treatment brolucizumab; IOI subsequently developed 19 patients. cytokines upregulated subsequent development IOI, compared the cytokine levels between and non-IOI groups. We also plasma 20 who age- sex-matched controls to...
Although intraocular pressure (IOP) is the most definitive cause of glaucoma, a subtype open angle glaucoma (OAG) termed normal tension (NTG), which occurs in spite IOP, accounts for large part cases, especially Japan. To find common genetic variants contributing to NTG Japanese patients, we conducted genome-wide association study (GWAS). We performed first screening 531,009 autosomal SNPs with discovery cohort 286 cases and 557 controls, then second top 30 suggestive loci an independent 183...
The distribution of uveitis varies with genetic, ethnic, geographic, environmental, and lifestyle factors. Epidemiological information about the patterns is useful when an ophthalmologist considers diagnosis uveitis. Therefore, it important to identify causes over years in different regions. purposes this study were characterize patients who first arrived at University Tokyo Hospital 2013–2015, analyze changes from 2004 2012 2013–2015. We retrospectively identified 750 newly visited Uveitis...
To determine changes in multiple cytokine concentrations the anterior chamber during induction phase of ranibizumab treatment patients with neovascular age-related macular degeneration (AMD).This prospective study included 48 treatment-naïve AMD eyes who received three consecutive monthly injections at Japan Community Health Care Organization Tokyo Shinjuku Medical Center between November 2010 and August 2012. We collected ~0.2 mL aqueous humour before first third (2 months later)...
To investigate factors associated with cystoid macular edema (CME) after Descemet membrane endothelial keratoplasty (DMEK) in Asian eyes.
Purpose: Commercially available enzyme-linked immunosorbent assay (ELISA) kits are often used to monitor vascular endothelial growth factor (VEGF) levels in exudative age-related macular degeneration. To test their accuracy, this study performed measurements using the ELISA presence of anti-VEGF drugs. Methods: The concentrations bevacizumab, pegaptanib, or ranibizumab at 28 days and aflibercept 56 after an injection were estimated based on previous pharmacokinetic studies. Vascular measured...
Abstract Treatment of uveitis is complicated because its multiple aetiologies and elevation various inflammatory mediators. To determine the mediators that are elevated in vitreous humor according to aetiology uveitis, we examined concentrations 21 cytokines, 7 chemokines, 5 colony-stimulating/growth factors samples from 57 eyes with associated intraocular lymphoma (IOL, n = 13), sarcoidosis (n 15), acute retinal necrosis (ARN, or bacterial endophthalmitis (BE, 16). Samples idiopathic...
Abstract This single-center retrospective cohort study analyzed the 1-year real-world treatment outcomes of 63 consecutive eyes (of 60 patients) with neovascular age-related macular degeneration (nAMD) that were switched from intravitreal brolucizumab (IVBr) to faricimab (IVF) and managed on a treat-and-extend regimen discontinuation criteria. After switch, patients opted continue IVF, switch back IVBr, or receive photodynamic therapy (PDT). Thirty-eight continued 16 2 received PDT, 4 paused...
We have reported that Ia+ LEW rat corneal endothelial (CE) cells could not induce Ag-specific proliferation of MHC compatible T cell lines. Instead, the presence CE monolayers inhibited assays. now report on effect IL-2 production, IL-2R expression, and responsiveness cells. growth inhibition 1C3.4 hybridoma was unaffected by but production suppressed Similar cell-mediated secretion found with fresh splenic lymphocytes stimulated Con A. Controls showed neither nor their supernatant affected...
To investigate the frequencies of diseases in new patients with uveitis during 2007-2009 and compare them previously-reported data from University Tokyo Hospital.We retrospectively analyzed clinical records who visited outpatient clinic January 2007 to December 2009, compared those 1963-2006.During 2007-2009, 468 our hospital. Definite diagnoses were made 63.0%. Frequent include sarcoidosis (9.4%), Vogt-Koyanagi-Harada (VKH) disease (7.9%), herpetic iritis (6.0%), Behçet's (5.6%),...
Abstract Background This study reports the first cases of scleritis following intravitreal brolucizumab (IVBr) injection for nAMD, emphasizing need to be aware possibility IVBr injections. Case presentation 1. A 74-year-old Japanese man with nAMD complained conjunctivitis and decreased vision in right eye 8 days after his eighth injection. Examination revealed without anterior inflammation. Topical 0.1% betamethasone 0.3% gatifloxacin drops were started. The worsened 2 weeks became painful....
To investigate whether sub-Tenon injection of triamcinolone acetonide (STTA) combined with anti-vascular endothelial growth factor (VEGF) prolongs the recurrence intervals macular edema (ME) for chronic retinal vein occlusion (RVO) and to differences in intraocular inflammatory cytokines between good responders (GRs) non-responders (NRs). This retrospective, observational study involved 42 eyes patients ME due RVO who had received only anti-VEGF ≥ 1 year were transitioned combination...
Purpose: To investigate the association between aqueous humor (AH) suppressant eye drops and concentration of aflibercept at 1 month after intravitreal injection. Methods: This retrospective study included 17 eyes patients with neovascular age-related macular degeneration (nAMD) who used for their glaucoma received first (IVA) two centers July 2013 November 2020. As controls, we enrolled 40 age-, sex-, axial length–matched nAMD were not using any medication that would affect AH circulation....