A5089380130- Corneal surgery and disorders
- Neuropeptides and Animal Physiology
- Regulation of Appetite and Obesity
- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Hypothalamic control of reproductive hormones
- Corneal Surgery and Treatments
- Birth, Development, and Health
- Growth Hormone and Insulin-like Growth Factors
- Pregnancy and preeclampsia studies
- Intraocular Surgery and Lenses
- Stress Responses and Cortisol
- Ophthalmology and Visual Impairment Studies
- Hormonal and reproductive studies
- Neuroscience of respiration and sleep
- Neonatal Respiratory Health Research
- Retinal and Optic Conditions
- Cerebral Venous Sinus Thrombosis
- Retinal Diseases and Treatments
- Sleep and Wakefulness Research
- Receptor Mechanisms and Signaling
- Heart Rate Variability and Autonomic Control
- Diet and metabolism studies
- Retinal and Macular Surgery
- Pituitary Gland Disorders and Treatments
University of Debrecen
2013-2025
University of Szeged
2013
Technical University of Košice
2010-2012
Leiden University
2007-2009
Amsterdam UMC Location Vrije Universiteit Amsterdam
2004-2008
University Medical Center
2004-2007
Semmelweis University
1988-2007
University Hospital and Clinics
2007
Hungarian Academy of Sciences
2007
Leiden University Medical Center
2005-2006
Abstract This prospective cohort study is aimed to investigate circadian variations in corneal parameters, focusing on sleep-deprived subjects. Sixty-four healthy individuals (age range: 21–76 years) actively participated this study, undergoing examinations at least five times within a 24-hour timeframe. The analysis encompassed keratometric parameters of the cornea’s front (F) and back (B) surfaces, refractive power flattest steepest axes (K1, K2), astigmatism (Astig) its axis (Axis),...
The present study reports for the first time distribution of androgen receptor immunoreactivity (AR-ir) in human hypothalamus ten subjects (five men and five women) ranging age between 20 years 39 using antibody PG21. Prolonged postmortem delay (72:00 hours) or fixation (100 days) did not influence AR-ir. In men, intense nuclear AR-ir was found neurons horizontal limb diagonal band Broca, lateromamillary nucleus (LMN), medial mamillary (MMN). An intermediate staining sexually dimorphic...
Changes in cardiac substrate utilisation leading to altered energy metabolism may underlie the development of diabetic cardiomyopathy. We studied cardiomyocyte uptake and role fatty acid translocase CD36 relation vivo function rats fed a high-fat diet (HFD). Rats were exposed an HFD or low-fat (LFD). In was monitored by echocardiography. Substrate determined isolated cardiomyocytes. Feeding for 8 weeks induced left ventricular dilation systolic phase decreased fractional shortening ejection...
Abstract Objective The CACNA1A gene encodes the pore‐forming subunit of neuronal Ca V 2.1 2+ channels. In patients, S218L mutation causes a dramatic hemiplegic migraine syndrome that is associated with ataxia, seizures, and severe, sometimes fatal, brain edema often triggered by only mild head trauma. Methods We introduced into mouse Cacna1a studied mechanisms for analyzing phenotypic, molecular, electrophysiological consequences. Results mice faithfully mimic clinical features human...
Transcutaneous PO2, heart rate, and aortic blood pressure were measured i 10 mechanically-ventilated newborn infants to assess the degree course of hypoxaemia, monitor cardiovascular respiratory changes during tracheal toilet. Five weighed less than 1250 (mean 994), g 5 greater 1750 2216) g. During suction TcPO2 fell from 68 +/- 27 SD) 43 23 mmHg, rate 144 8 123 25 beats/minute, but increased 44 24 49 mmHg. Hypoxaemia (TcPO2 50 mmHg) occurred in 7 initially well-oxygenated when suctioned....
A link exists between low birth weight and diseases in adulthood, such as hypertension, cardiovascular disease, insulin resistance. Intrauterine growth restriction (IUGR) has been used to explain this association shown lead a nephron endowment humans. reduction glomerular number described animal models with induced well but not animals spontaneous weight. It therefore is debatable whether the are suitable. The effect on size was studied rats naturally occurring IUGR experimental IUGR, by...
To identify optical coherence tomography (OCT) parameters that predict postoperative best corrected visual acuity (BCVA) and are based on recent understanding of the pathomechanism idiopathic full thickness macular hole (iFTMH) formation closure.
Célkitűzés: A Debreceni Szembank 30 éves működésének (1994–2023), a szaruhártyadonorok demográfiai jellemzőinek, donorszövetek beszerzésének, tárolásának és felhasználásának, szétosztásának bemutatása, valamint szembanki gyakorlat hosszú távú eredményeinek közreadása. Módszerek: Egyetem Szemklinikáján 1994 2023 között folytatott gyakorlatok retrospektív elemzését végeztük el. Összegyűjtöttük szaruhártya-donációra (a donor neme életkora, halálának oka, halál bekövetkeztétől eltelt idő...
We aimed to determine the effects of night-shift work on corneal parameters in thirty-five healthy individuals (24–59 years) a retrospective cohort study. Among them, 12 hospital nurses regularly worked two shifts, spending third their nights awake, whereas 23 age-matched controls never shifts and slept regularly. Measurements were performed at least five times within h. analyzed keratometric front (F) back (B) surfaces, including refractive power flattest steepest axes (K1, K2), astigmatism...
In a previous study we found androgen receptor (AR) sex differences in several regions throughout the human hypothalamus. Generally, men had stronger nuclear AR immunoreactivity (AR-ir) than women. The strongest labeling was caudal hypothalamus mamillary body complex (MBC), which is known to be involved aspects of cognition and sexual behavior. present carried out investigate whether difference AR-ir MBC related orientation or gender identity (i.e. feeling being male female) circulating...
<b><i>Purpose:</i></b> To study the association between different types of mediators in tear fluid and topographic indices characterizing severity keratoconus (KC). <b><i>Methods:</i></b> In this study, nonstimulated samples were collected from 14 eyes 11 patients with KC. The following measured by corneal topography: maximum K value, average Klyce/Maeda index (KCI), Smolek/Klyce index, opposite sector center/surround prediction standard...
Abstract Our purpose was to prospectively analyze the age-related changes of corneal Scheimpflug parameters in healthy subjects. Thirty-five eyes 35 volunteers (age 14–67 years) were investigated with an average interval 3.6 years. Changes (flattest keratometric reading at anterior (K1F) and posterior surface (K1B), steepest (K2F) surface, astigmatism, astigmatism (AstigB), flat axis (AxisB), thinnest pachymetric value (PachyMin), volume (CV10-mm)) analyzed. K1F K2F decreased significantly...
Decussations of descending fibers the hypothalamic paraventricular nucleus (PVN) were investigated by using Phaseolus vulgaris-leucoagglutinin (PHA-L) in intact and brainstem-operated rats. Fibers descend ipsilaterally along brainstem spinal cord decussate at four levels: 1) Supramamillary decussations (SM). PVN reach this area through lateral hypothalamus third ventricle dorsal hypothalamus. In posterior some crossover SM terminate supramamillary region bilaterally. 2) Pontine tegmentum....
Keratoconus (KC) is the most common primary corneal ectatic disease which has considerable importance in public health. Corneal collagen crosslinking (CXL) a procedure to mitigate progression of KC and reduce demand for transplantation. Although studies have proven efficacy CXL regarding shape, none investigated effects on tear biomarkers are useful tools understand molecular mechanisms behind CXL. Our purpose was determine effect mediators patients with analyze associations changes. Tear...
The release of different cytokines and mediators in tears patients with keratoconus (KC) wearing contact lenses (CLs) may contribute to the pathology KC.Cohort study was established KC rigid gas permeable (RGP) CL (group I), ametropia silicone hydrogel (Si-Hi) II) ametropic RGP III).Our findings indicate that before wear, epidermal growth factor (EGF) tissue-type plasminogen activator (t-PA) attenuated, whereas matrix metalloproteinase (MMP)-9, interleukin (IL)-6, chemokine (C-C motif)...
Purpose: To find immunomediator combinations which could sensitively indicate keratoconus progression.Methods: Tear samples of 42 patients with were collected at baseline and the end a one-year follow-up. The concentrations 13 mediators measured by CBA. Based on Pentacam HR examination, eyes divided into non-progressive progressive group.Results: At follow-up, significant differences observed in release IFNγ, IL-13, IL-17A, CCL5, MMP-13 PAI-1 between two groups. Changes five parameters...
Intrauterine growth restriction (IUGR) is one of the major causes short stature in child- and adulthood. The cause IUGR unknown, however, an impaired uteroplacental function during second half human pregnancy might be important factor, by affecting programming somatotropic axis leading to postnatal failure into Two rat models with perinatally induced retardation were used examine long-term effects perinatal insults on growth. rats prepared from pregnant dams, a bilateral uterine artery...
<i>Objective:</i> To determine the levels of interleukin 6 (IL-6) and 8 (IL-8/CXCL-8) in tears collected from eyes normal individuals patients with different irritative eye diseases, order to acquire information on immunological changes occurring during early postoperative period following various forms surgery, including penetrating keratoplasty (PKP). <i>Methods:</i> IL-6 IL-8 were measured aid human ultrasensitive ELISA kits non-stimulated PKP or cataract...