A5060735046- Blood Pressure and Hypertension Studies
- Viral-associated cancers and disorders
- Chemical Synthesis and Analysis
- Hormonal Regulation and Hypertension
- Cytomegalovirus and herpesvirus research
- Health disparities and outcomes
- Receptor Mechanisms and Signaling
- Parvovirus B19 Infection Studies
- Global Health Care Issues
- Analytical Methods in Pharmaceuticals
- COVID-19 epidemiological studies
- Synthesis and Biological Evaluation
- Paraoxonase enzyme and polymorphisms
- Head and Neck Cancer Studies
- Neuropeptides and Animal Physiology
- Peptidase Inhibition and Analysis
- Neuroscience and Neuropharmacology Research
- Apelin-related biomedical research
- Insurance, Mortality, Demography, Risk Management
- Sodium Intake and Health
- Nutritional Studies and Diet
- Synthesis of Organic Compounds
- Lymphoma Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Estrogen and related hormone effects
Semmelweis University
2022-2025
Hungarian National Museum
2024
Institute of Archaeology
2024
Budapest University of Technology and Economics
2024
Ludwig-Maximilians-Universität München
2024
Government of Hungary
2011-2022
Czech Academy of Sciences
2021-2022
Czech Academy of Sciences, Institute of Microbiology
2021-2022
University of Debrecen
2006-2021
Government Office of the Capital City Budapest
2011-2021
D-Phe-Pro-Arg-H sulfate (GYKI-14166) is a highly active and selective inhibitor of thrombin both in vitro vivo. Recent studies on the stability neutral aqueous solution at higher temperature have revealed that it transformed into inactive 5,6,8,9,10,10a-hexahydro-2-(3'- guanidinopropyl)-5-benzyl-6-oxo- imidazo[1,2-a]pyrrolo[2,1-c]pyrazine. No such inactivation could be observed with Boc-D-Phe-Pro-Arg-H (GYKI-14451), but this compound was far less specific than free peptide as inhibited and,...
COVID-19 epidemic has been suppressed in Hungary due to timely non-pharmaceutical interventions, prompting a considerable reduction the number of contacts and transmission virus. This strategy was effective preventing growth reducing incidence low levels. In this report, we present first epidemiological statistical analysis early phase outbreak Hungary. Then, establish an age-structured compartmental model explore alternative post-lockdown scenarios. We incorporate various factors, such as...
The study was designed to explore the development of general practitioner (GP) shortage in primary care and its characteristics Hungary.
Introduction We describe COVID-19 morbidity, mortality, case fatality and excess death in a country-wide study of municipalities Hungary, exploring the association with socioeconomic status. Methods The spatial distribution mortality was mapped using hierarchical Bayesian smoothed indirectly standardised ratios. Indirectly ratios were used to evaluate between deprivation outcome measures. looked separately at morbidity 10 districts highest lowest share Roma population. Results Compared...
Abstract Background While outcomes of very low birth weight (VLBW) infants have improved significantly in high-income countries over recent decades, data from Central-Eastern Europe are lacking. The study aimed to evaluate trends VLBW infant and hypothesized that a variability exists the performance NICUs Hungary. Methods This was population-based cohort infants, conducted between 2014–2016 (Epoch 1); 2019–2021 2) involving all Level III primary composite outcome death or any five major...
Subnuclear distribution of the human herpesvirus-8 (HHV-8)- encoded nuclear protein LNA-1 was analysed at high resolution in body cavity (BC) lymphoma-derived cell lines, hybrids between BC cells and various mouse freshly infected K562 ECV lines. Three-dimensional reconstruction nuclei from optical sections quantitative analysis fluorescence relation to chromatin showed that associates preferentially with border heterochromatin interphase nuclei. This further confirmed following systems:...
Governments are increasingly looking to vaccination provide a path out of the COVID-19 pandemic. Hungary offers an example investigate whether social inequalities compromise what successful vaccine program can achieve. morbidity, mortality, and coverage were characterized by calculation indirectly standardized ratios in Hungarian population during third pandemic wave at level municipalities, classified into deprivation quintiles. Then, their association with socioeconomic was assessed using...
Pulmonary infections caused by Bordetella pertussis used to be the prime cause of infant mortality in pre-vaccine era and mouse models pneumonia served characterization B. virulence mechanisms. However, biologically most relevant catarrhal disease stage transmission has not been adequately reproduced adult mice due limited proliferation human-adapted pathogen on murine nasopharyngeal mucosa. We immunodeficient C57BL/6J MyD88 KO achieve human-like high counts 108 viable bacteria per nasal...
In an attempt to produce better cytotoxic analogues, chemotherapeutic antineoplastic radicals including alkylating nitrogen mustard derivative of D-phenylalanine (D-melphalan), reactive cyclopropane, anthraquinone derivatives [2-(hydroxymethyl)anthraquinone and the anticancer antibiotic doxorubicin], antimetabolite (methotrexate) were coupled suitably modified agonists antagonists luteinizing hormone-releasing hormone (LH-RH). Analogues with D-lysine6 D-ornithine6 or N...
We studied the usefulness of transcranial Doppler sonography for assessing changes in vasoreactivity patients with hypertension and hemodynamic consequences hypertension.The study group comprised 25 chronic severe age- sex-matched healthy subjects. Cerebrovascular reserve capacity was assessed by recording blood flow velocity both middle cerebral arteries before 5, 10, 15, 20 minutes after intravenous injection 1 g acetazolamide (Diamox). Blood pressure, gases, other parameters were also...
Abstract The demographic transition poses a significant challenge for health systems, especially in Central and Eastern European (CEE) countries, where the healthcare needs of aging populations are on rise. This study aimed to describe compare status utilization services among elderly residing urban rural areas most deprived region Hungary. A comprehensive survey was conducted 2022, involving randomly selected sample 443 older adults (≥ 65 years) Northeast Multivariable logistic regression...
Background: The aetiology and factors leading to the progression of laryngeal cancer are still unclear. Although human papillomavirus (HPV) has been suggested play a role, reports concerning effect HPV infection on tumour development controversial. Recently, transfusion transmitted virus (TTV) was role in certain infections as causative or coinfecting agent. Aims: To investigate whether squamous cell carcinoma is associated with coinfection TTV HPV. Methods: prevalence investigated using...
Background: Recently, research focus has returned to amenable mortality health care, despite the decreasing trend, as it remains a significant contributor social and economic loss due premature death. This article assesses trends of over time and, its spatial inequalities with respect deprivation, in Hungary. Methods: An ecological analysis care was carried out using smoothed indirectly standardized ratios, calculated by full hierarchical Bayesian methods, at municipality level. The...
Bone destruction is a key step in the progression of cholesteatomas. Some lesions can grow without affecting surrounding anatomic structures, whereas others cause severe bone despite their limited size. This study aims to identify factors that could play important role during invasion disease.Cholesteatoma tissue samples were examined immunohistochemically. Tissue arranged on basis (destructive cholesteatomas [DC] and nondestructive [NDC]). Double-immunofluorescent labeling was performed...
Diagnosed cases of tick-borne encephalitis (TBE) and Lyme disease (LD) have been reportable infectious diseases in Hungary since 1977 1998, respectively. Clinically diagnosed registered the National Database Epidemiological Surveillance System (NDESS). All reported TBE are confirmed by laboratory serological and, if necessary, PCR tests, whereas LD mainly based on appearance erythema migrans concurring with possible exposure tick bite. Our work is first comparative epidemiological...
The risk of premature mortality caused by cardiovascular diseases (CVDs) is approximately three times higher in the Central Eastern European region than high income countries, which suggests a lack and/or ineffectiveness preventive interventions against CVDs. aim present study was to provide data on relationship between CVD mortality, statin utilization as medication and socioeconomic deprivation at district level Hungary. As conceptually new approach, prescription statins, redemption ratio...
Abstract COVID-19 epidemic has been suppressed in Hungary due to timely non-pharmaceutical interventions, prompting a huge reduction the number of contacts and transmission virus. This strategy was effective preventing growth reducing incidence low levels. In this report, we present first epidemiological statistical analysis early phase outbreak Hungary. Then, establish an age-structured compartmental model explore alternative post-lockdown scenarios. We incorporate various factors, such as...
~t~duction Enkephalins, the endogenous opioid peptides: Tyr-Gly-Gly-Phe-Met and -Leu [ 11, have been known to show much higher agonist potency in mouse vas deferens preparation (MVD) than guinea-pig ileum assay system (GPI) [2-61.The high MVD/GPI ratio is characteristic of enkephalins their synthetic analogs unless pentapeptides are terminated by an amide function.For instance, ratios calculated for Met-enkephalin, its D-Ala2 analog [D-Ala2, Met']-enke-ph~~ide were 9.0,8.4 2.0, respectively...