A5069569036- Gut microbiota and health
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Drug Transport and Resistance Mechanisms
- PARP inhibition in cancer therapy
- Skin Protection and Aging
- Light effects on plants
- Genomics, phytochemicals, and oxidative stress
- CRISPR and Genetic Engineering
- bioluminescence and chemiluminescence research
- Mitochondrial Function and Pathology
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Sirtuins and Resveratrol in Medicine
- RNA modifications and cancer
- Cancer Treatment and Pharmacology
- Glutathione Transferases and Polymorphisms
- RNA Interference and Gene Delivery
- Probiotics and Fermented Foods
- Liver Disease Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Contact Dermatitis and Allergies
- Cancer Research and Treatments
- Milk Quality and Mastitis in Dairy Cows
University of Debrecen
2015-2024
University of Szeged
2023
Hungarian Academy of Sciences
2016
In-Q-Tel
2015
Abstract Recent studies showed that changes to the gut microbiome alters microbiome-derived metabolome, potentially promoting carcinogenesis in organs are distal gut. In this study, we assessed relationship between breast cancer and cadaverine biosynthesis. Cadaverine treatment of Balb/c female mice (500 nmol/kg p.o. q.d.) grafted with 4T1 cells ameliorated disease (lower mass infiltration primary tumor, fewer metastases, lower grade tumors). cell lines corresponding its serum reference...
Despite intensive efforts to improve therapies, small cell lung cancer (SCLC) still has a dismal median survival of 18 months. Since miR-126 is under-expressed in the majority SCLC tumors, we investigated effect overexpression on proliferation and cycle distribution H69 cells. Our results demonstrate that inhibits cells, by delaying cells G1 phase. Short interfering RNA (siRNA) mediated suppression SLC7A5, predicted target mir-126, same We also show for first time SLC7A5 direct miR-126.
Oncobiotic transformation of the gut microbiome may contribute to risk breast cancer. Recent studies have provided evidence that secretes cytostatic metabolites inhibit proliferation, movement, and metastasis formation cancer cells. In this study, we show indolepropionic acid (IPA), a bacterial tryptophan metabolite, has properties. IPA selectively targeted cells, but it had no effects on non-transformed, primary fibroblasts. cell-based animal experiments, showed supplementation reduced...
In breast cancer patients, the diversity of microbiome decreases, coinciding with decreased production cytostatic bacterial metabolites like lithocholic acid (LCA). We hypothesized that LCA can modulate oxidative stress to exert effects in cells. Treatment cells nuclear factor-2 (NRF2) expression and increased Kelch-like ECH associating protein 1 (KEAP1) via activation Takeda G-protein coupled receptor (TGR5) constitutive androstane (CAR). Altered NRF2 KEAP1 subsequently led glutathione...
Abstract Lithocholic acid (LCA) is a secondary bile acid. LCA enters the circulation after bacterial synthesis in gastrointestinal tract, reaches distantly located cancer cells, and influences their behavior. was considered carcinogenic, but recent studies demonstrated that has antitumor effects. We assessed possible role of pancreatic adenocarcinoma. At serum reference concentration, induced multi-pronged antineoplastic program adenocarcinoma cells. inhibited cell proliferation...
Expression of microRNAs (miRNAs) is characteristically altered in cancer, and they may play a role cancer development progression. The authors performed microarray real-time quantitative reverse transcriptase–polymerase chain reaction (RT-PCR) analyses to determine the miRNA expression profile primary small cell lung cancer. Here we show that at least 24 miRNAs are differentially expressed between normal (SCLC) tumors. These include miR-301, miR-183/96/182, miR-126, miR-223, which...
Changes to bacterial metabolite-elicited signaling, in oncobiosis associated with breast cancer, plays a role facilitating the progression of disease. We show that indoxyl-sulfate (IS), tryptophan metabolite, has cytostatic properties models cancer. IS supplementation, concentrations corresponding human serum reference range, suppressed tumor infiltration surrounding tissues and metastasis formation murine model In cellular models, NRF2 induced iNOS, leading induction oxidative nitrosative...
Abstract Background Commensal bacteria secrete metabolites that reach distant cancer cells through the circulation and influence behavior. Deoxycholic acid (DCA), a hormone-like metabolite, is secondary bile specifically synthesized by intestinal microbes. DCA may have both pro- antineoplastic effects in cancers. Methods results The pancreatic adenocarcinoma cell lines, Capan-2 BxPC-3, were treated with 0.7 µM DCA, which corresponds to reference concentration of human serum. influenced...
Zinc is an essential microelement; its importance to the skin highlighted by severe symptoms in hereditary or acquired zinc deficiency, improvement of several conditions using systemic topical preparations and induced intracellular release upon UVB exposure, which main harmful environmental factor skin. Understanding molecular background role may help gain insight into pathology disorders provide evidence for therapeutic usefulness supplementation. Herein, we studied effects chloride (ZnCl2)...
Breast cancer patients are characterized by the oncobiotic transformation of multiple microbiome communities, including gut microbiome. Oncobiotic impairs production antineoplastic bacterial metabolites. The goal this study was to identify metabolites with properties. We constructed a 30-member metabolite library and screened compounds for effects on cell proliferation epithelial-mesenchymal transition. were applied 4T1 murine breast cells in concentrations corresponding reference serum...
Abstract Background The formation of metastases and the efficacy systemic therapies in cutaneous malignant melanoma (CMM) depend on characteristics tumour cells host immune response. Aberrant expression metallothionein (MT) has been observed several types cancers with poor prognoses. Objective To perform an immunohistochemical study primary CMM comparing MT tumours without ( n = 23) to that samples haematogenous examine correlation between staining immunological markers relevant progression....