A5101763225- Antimicrobial Resistance in Staphylococcus
- Gut microbiota and health
- Animal Disease Management and Epidemiology
- T-cell and Retrovirus Studies
- HIV Research and Treatment
- Sepsis Diagnosis and Treatment
- Vector-Borne Animal Diseases
- Streptococcal Infections and Treatments
- Pneumonia and Respiratory Infections
- Thyroid Disorders and Treatments
- Epigenetics and DNA Methylation
- Bacterial Identification and Susceptibility Testing
- Bacterial biofilms and quorum sensing
- Antibiotic Resistance in Bacteria
- Adenosine and Purinergic Signaling
- Hemodynamic Monitoring and Therapy
- Ion channel regulation and function
- Cytomegalovirus and herpesvirus research
- HIV/AIDS drug development and treatment
- Clostridium difficile and Clostridium perfringens research
- Antibiotics Pharmacokinetics and Efficacy
- Cardiac electrophysiology and arrhythmias
- ATP Synthase and ATPases Research
- Oral microbiology and periodontitis research
- Nosocomial Infections in ICU
University of Debrecen
2013-2022
Geographical Institute
2017
Eötvös Loránd University
2015
Semmelweis University
2004
Czech Academy of Sciences, Institute of Microbiology
1997
Danish Cancer Society
1995
Austrian Academy of Sciences
1993
Oncobiotic transformation of the gut microbiome may contribute to risk breast cancer. Recent studies have provided evidence that secretes cytostatic metabolites inhibit proliferation, movement, and metastasis formation cancer cells. In this study, we show indolepropionic acid (IPA), a bacterial tryptophan metabolite, has properties. IPA selectively targeted cells, but it had no effects on non-transformed, primary fibroblasts. cell-based animal experiments, showed supplementation reduced...
During recent years, interest in the use of bacteriophages as biocontrol agents against foodborne pathogens has increased, particularly for members family Enterobacteriaceae, with pathogenic Escherichia coli, Shigella and Salmonella strains among them. Here, we report isolation characterisation 12 novel T5-like from confiscated food samples. All bacterophages effectively lysed E. coli K-12 an average burst size 40 PFU/cell were able to infect representing enterohaemorrhagic (EHEC),...
The occurrence and genetic variability of Candida parapsilosis isolates in two Hungarian hospitals, located Debrecen Pécs, were examined. Among the 209 examined, 20 found to belong C. sensu lato, based on morphological, physiological molecular data. frequency (9.6%) was lower than that observed Europe but higher previously Hungary. lato also examined using random amplified polymorphic DNA (RAPD) analysis sequence intergenic transcribed spacer (ITS) region rRNA gene cluster. relatively high,...
Abstract Background Post-operative pulmonary infection often appears to result from aspiration of pathogens colonizing the oral cavity. It was hypothesized that impaired periodontal status and pathogenic bacteria significantly contribute development pneumonia following neurosurgical operations. Further, prophylactic effects a single dose preoperative cefazolin on were investigated. Methods A matched cohort 18 patients without postoperative lung complications compared 5 who developed within...
Effects of nutraceuticals on the intestinal microbiota are receiving increased attention; however, there few studies investigating their effects broiler meat production. The aim this study was to implement feeding strategies and carry out a comprehensive trial examining interplay between natural biologically active compounds such as carotenoids, anthocyanins, fermentable oligosaccharides, synbiotics gastrointestinal tract microbiota. Our program applied an intensive production system with...
Natural products used in the treatment of acne vulgaris may be promising alternative therapies with fewer side effects and without antibiotic resistance. The objective this study was to formulate creams containing Spirulina (Arthrospira) platensis therapy. belongs group micro algae contains valuable active ingredients. aim select appropriate nonionic surfactants for formulations order enhance diffusion substance certify antioxidant antibacterial activity platensis-containing creams....
Using the single-strand conformation polymorphism and heteroduplex analyses, P53 RB genes were analyzed in cell samples from twenty-eight patients with chronic myeloid leukemia (CML) both at diagnosis onset of accelerated phase (AP) disease. No alterations or found any (CP) samples. Structural abnormalities gene observed ten AP within exons 4, 5, 7 9. Of cases disease altered genes, five also suffered deletion other allele. Alterations could be detected six samples, aberrant band patterns...
To study the mechanism of complement-mediated antibody-dependent enhancement (C'-ADE) HIV infection which may play a significant role in progression HIV-disease.In vitro complement activating and HIV-infection enhancing abilities three human anti-gp41 monoclonal antibodies (MAb) were tested. C'-ADE was estimated using HIV-1IIIB CR2 (CD21)-carrying MT-4 target cells. Normal serum (NHS), purified C1q, C1q-deficient (C1qD) C2-deficient (C2D) sera applied as sources.All MAb mediated increased...
Objective: We have previously demonstrated that complement-mediated antibody-dependent enhancement (C-ADE) of HIV-1 infection correlates with accelerated immunosuppression and disease progression in HIV-1-infected individuals. In the present work relationship between C-ADE plasma RNA concentrations was studied to determine effect on viral replication. Methods: Three studies were performed: (a) determined serum aliquots taken at same time from 98 HIV patients, mostly advanced stage disease;...
The pathophysiology of hemorheological and microcirculatory disturbances in septic process -mostly during the early hours- still not clarified all details, yet. In anesthetized pigs living E. coli (ATCC 25922 strain) was administered intravenously with an increasing concentration ani mals were observed for 8 hours. Before intervention every 2 hours arterial (cannulated femoral artery) venous external jugular vein) blood samples collected laboratory tests: plasma viscosity, ESR, leukocyte...
Interleukin-1 receptor-associated kinase (IRAK)-4 deficiency is a rare primary immunodeficiency disorder characterized by severe, invasive infections with Streptococcus pneumoniae. Using the PFGE technique genetic linkage was found between two S. pneumoniae serotype 14 isolates causing arthritis and meningitis at 3 5(1/2) years of age, respectively, in boy IRAK-4 deficiency. This finding suggested that patients may harbour persistent strains pneumococci. Alternatively, reinfection from close...
Abstract Our objective was to compare the activity ceftazidime-avibactam (C/A) and ceftolozane–tazobactam (C/T) against multidrug (including carbapenem) resistant Pseudomonas aeruginosa clinical isolates collected from six diagnostic centers in Hungary reveal genetic background of their carbapenem resistance. Two hundred fifty consecutive, non-duplicate, carbapenem-resistant (MDR) P. were 2017. Minimal inhibitory concentration values ceftazidime, cefepime, piperacillin/tazobactam, C/A C/T...
Prophylactic use of antibiotics to prevent postoperative infections is a routine method in neurosurgery. Little known about the period effectiveness applied only for purposes operation. The actual concentration cefazolin was determined serum, contents wound drains, and cerebrospinal fluid 24-hour after administration 1 g just prior skin incision 8 patients undergoing lumbar discectomy 11 craniectomy. antibiotic then compared with minimal inhibitory values 10 different bacterial species. For...
ABSTRACT Nosocomial bronchopneumonia is a frequent complication in patients with chronic intratracheal intubation. Despite targeted antibiotic treatment, production of abundant bronchial secretion containing pathogen bacteria often tends to be chronic, and so mortality drastically increases. This problem led an investigation the penetration five cephalosporin antibiotics into sputum. Serum sputum were collected from 24 chronically intubated having purulent nosocomial treated intensive care...
Thyroid-derived T-cells from patients with Graves' disease were analyzed for their reactivity to recombinant heat shock proteins (hsp) and autologous thyroid epithelial cells (TEC). Five of six uncloned T-cell lines responded stimulation mycobacterial 71-kilodalton (kDa) hsp cross-reacted the corresponding amoebial human proteins. Only one line reacted 65-kDa hsp. also showed a proliferative response TEC, which could be increased in four lines, when expression was induced by stress before...
Abstract Human herpesvirus 6 (HHV‐6) and human immunodeficiency virus type 1 (HIV‐1) may interact during transplacental transmission of HIV‐1. The placental syncytiotrophoblast layer serves as the first line defense fetus against viruses. Patterns replication HHV‐6 variant A (HHV‐6A) HIV‐1 were analyzed in singly dually infected term cells cultured vitro. For this purpose, GS strain HHV‐6A Ba‐L IIIB strains used. was restricted at level early gene products syncytiotrophoblasts, whereas no...
Risk factors for invasive infections by heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) may involve resistance to opsonophagocytosis and bacterial killing. hVISA strains typically have a thickened cell wall with altered peptidoglycan cross-linking. To determine whether be endowed an increased phagocytosis, this study assessed the characteristics of uptake killing granulocytes three strains. All isolates were analysed multilocus sequence typing staphylococcal chromosome...
OBJECTIVE: In a fulminant porcine sepsis model, we determined the kinetics of hypoxia induced changes in relation to parameters and markers organ damage. METHODS: Female pigs were challenged by live Escherichia coli samples analysed up 4 hours. Bone marrow reactions deter mined analysing immature forms peripheral blood cells hematology analyser light microscopy. Platelet mitochondrial membrane depolarisation was flow cytometry. RESULTS: Core temperature, modified shock index lactate levels...
Listeria monocytogenes is a foodborne pathogen, and the detection differentiation of this bacterium from nonpathogenic species are great importance to food industry. Differentiation very difficult, even with sophisticated MALDI-TOF MS technique because close genetic relationship usual gene transfer. The present paper emphasizes difficulties through standardized confirmation according ISO 11290-1:1996 basic available L. methods tests (such as API test, analysis, hly PCR). With increase...