A5074040734- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Drug Transport and Resistance Mechanisms
- Advancements in Transdermal Drug Delivery
- RNA Interference and Gene Delivery
- Crystallization and Solubility Studies
- Flavonoids in Medical Research
- Natural product bioactivities and synthesis
- Silymarin and Mushroom Poisoning
- Peptidase Inhibition and Analysis
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Inhalation and Respiratory Drug Delivery
- Essential Oils and Antimicrobial Activity
- Neonatal Respiratory Health Research
- Phytochemistry and Biological Activities
- Lipid Membrane Structure and Behavior
- Carbohydrate Chemistry and Synthesis
- Drug-Induced Hepatotoxicity and Protection
- Protein purification and stability
- Cell Adhesion Molecules Research
- Radiopharmaceutical Chemistry and Applications
- MicroRNA in disease regulation
- Antimicrobial agents and applications
University of Debrecen
2015-2024
Affiliated Zhongshan Hospital of Dalian University
2019
Hungarian Academy of Sciences
2006
Cyclodextrins are widely used excipients, composed of glucopyranose units with a cyclic structure. One their most important properties, is that inner cavity hydrophobic, while surface hydrophilic. This enables them for the complex formation lipophilic molecules. They have several applications in pharmaceutical field like solubility enhancers or building blocks larger drug delivery systems. On other hand, they numerous effects on cells biological barriers. In this review properties...
Prior exposure to microenvironmental signals could fundamentally change the response of macrophages subsequent stimuli. It is believed that T helper-2 (Th2)-cell-type cytokine interleukin-4 (IL-4) and Toll-like receptor (TLR) ligand-activated transcriptional programs mutually antagonize each other, no remarkable convergence has been identified between them. In contrast, here, we show IL-4-polarized established a hyperinflammatory gene expression program upon lipopolysaccharide (LPS)...
Chrysin is a bioflavonoid that can be found in natural products such as honey and propolis, it possesses several biological effects antioxidant, anti-inflammatory, anti-cancer activity. However, poorly soluble water, its bioavailability limited. The aim of this research to investigate the chrysin solubilization capacity different β-cylcodextrin derivatives compare their activities. was complexed with β-cyclodextrin (βCD), hydroxypropyl-β-, (HPBCD) sulfobutylether-β-, (SBECD),...
Nowadays, polyethylene glycols referred to as PEGs are widely used in cosmetics, consumer care products, and the pharmaceutical industry. Their advantageous properties such chemical stability, low immunogenicity, high tolerability explain why applied many fields of formulations including parenteral, topical, ophthalmic, oral, rectal preparations also modern drug delivery systems. Given their extensive use, they considered a well-known group chemicals. However, number large-scale comparative...
Cyclodextrins, even the 6-membered α-cyclodextrin, are approved in various pharmacopoeias as pharmaceutical excipients for solubilizing and stabilizing drugs well controlling drug release. Recently α-cyclodextrin has also been marketed health food with beneficial effects on blood lipid profiles. However, concentration of used may be very high these cases, its toxic attributes have to seriously considered. The objective this study was investigate cytotoxicity various, differently substituted...
Cyclodextrins are widely used excipients for increasing the bioavailability of poorly water-soluble drugs. Their effect on drug absorption in gastrointestinal tract is explained by their solubility- and permeability-enhancement. The aims this study were to investigate penetration properties fluorescently labeled randomly methylated-beta-cyclodextrin (FITC-RAMEB) Caco-2 cell layer examine cellular entry cyclodextrins intestinal cells. permeability FITC-RAMEB through monolayers was very...
In sepsis, platelets may become activated via toll-like receptors (TLRs), causing microvascular thrombosis. Megakaryocytes (MKs) also express these receptors; thus, severe infection modulate thrombopoiesis. To explore the relevance of altered miRNAs in platelet activation upon we first investigated sepsis-induced miRNA expression septic patients. The effect abnormal Dicer level on was evaluated. were profiled vs. normal using TaqMan Open Array. We validated miR-26b with its target SELP...
Abstract Background A novel flow cytometric assay has been described in an accompanying report (Gombos et al., Methods The kinetics of the decrease immunofluorescence intensity was analyzed after addition raft‐preserving Triton X‐100 or Nonidet P‐40, both which disrupt entire membrane. Mild treatments by detergents leave cells attached to only those proteins that are anchored cytoskeleton rafts independent rafts. Agents affect microfilaments and modulate membrane levels cholesterol...
Nowadays, the sorbates are third largest group of antimicrobial preservatives in food and pharmaceutical industries, following parabens benzoates whose safety is questioned by recent publications. A disadvantage their pH dependence, as effect greatly reduced alkaline environment. The main, widely used sorbate derivatives sorbic acid potassium sorbate, no esters involved current industrial application. We aimed to test whether capable extend spectrum original molecule while maintaining its...
Turmeric has been used for decades its antioxidant and anti-inflammatory effect, which is due to an active ingredient isolated from the plant, called curcumin. However, extremely poor water-solubility of curcumin often limits bioavailability drug. The aim our experimental work was improve solubility thus by developing self-nano/microemulsifying drug delivery systems (SN/MEDDS). Labrasol Cremophor RH 40 as nonionic surfactants, Transcutol P co-surfactant isopropyl myristate oily phase were...
The aim of this study was to develop topical self-microemulsifying drug delivery systems (SMEDDS) containing antitumor agents (bleomycin, cisplatin and ifosfamide) investigate their inhibitory potential in SMEDDS on human cervical cancer HeLa cells. physicochemical properties cytostatic loaded were characterized. cytotoxicity main components also investigated. Their IC50 values determined. cells treated by different concentrations cisplatin, bleomycin ifosfamide alone various SMEDDS. effect...
Anthocyanins have several beneficial effects, especially on inflammatory and oxidative conditions. The pro-inflammatory cytokines, tumor necrosis factor-α (TNF-α) interleukin-1β (IL-1β), induce damage in the intestinal barrier participate pathogenesis of chronic bowel diseases. A number fruits high anthocyanin contents with strong biological activity which can support protective actions. Sour cherry (Prunus cerassus) is one richest anthocyanins; it has content cyanidins. aim this study was...
Plants with high amounts of antioxidants may be a promising therapy for preventing and curing UV-induced oxidative skin damage. The objective this study was to verify the efficacy topical formulations containing dissolved suspended Silybum marianum extract against UVB-induced stress in guinea pig HaCaT keratinocytes. Herbal Transcutol HP (TC) sucrose-esters were incorporated as penetration enhancers creams. Biocompatibility compositions tested on HeLa cells keratinocytes vitro models....
In the process of sepsis, activated platelets shed microvesicles containing microRNAs (miRNAs), which can be internalized by distinct recipient cells in circulation, consequently eliciting a potent capability to regulate their cellular functions different diseases. present study, human transferring miR-223 into endothelial via platelet-derived microparticles (PMPs) was investigated vitro during septic conditions with proposed mechanism involving downregulation enhanced expression...
Alpha-melanocyte-stimulating hormone (α-MSH) is a potent anti-inflammatory peptide with cytoprotective effect in various tissues. The present investigation demonstrates the ability of α-MSH to interact intestinal epithelial cell monolayers and mitigate inflammatory processes barrier. protective was studied on Caco-2 human monolayers, which were disrupted by exposure tumor necrosis factor-α interleukin-1β. barrier integrity assessed measuring transepithelial electric resistance (TEER)...