A5008898505- Drug Solubulity and Delivery Systems
- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Flavonoids in Medical Research
- Natural product bioactivities and synthesis
- Advancements in Transdermal Drug Delivery
- Essential Oils and Antimicrobial Activity
- Cardiac Ischemia and Reperfusion
- Phytochemistry and Biological Activities
- Drug Transport and Resistance Mechanisms
- Barrier Structure and Function Studies
- Lipid Membrane Structure and Behavior
- Neonatal Respiratory Health Research
- Silymarin and Mushroom Poisoning
- Antimicrobial agents and applications
- Heme Oxygenase-1 and Carbon Monoxide
- Protein purification and stability
- Natural Antidiabetic Agents Studies
- Liver physiology and pathology
- 3D Printing in Biomedical Research
- Crystallization and Solubility Studies
- Cardiac electrophysiology and arrhythmias
- Cystic Fibrosis Research Advances
- Hemoglobin structure and function
- Biomedical Research and Pathophysiology
University of Debrecen
2016-2025
Peking University
2019
Peking University People's Hospital
2019
Hungarian Academy of Sciences
2006
Institute of Materials and Environmental Chemistry
1967
Research and Development for Silicates and Ceramics
1966
Cyclodextrins are widely used excipients, composed of glucopyranose units with a cyclic structure. One their most important properties, is that inner cavity hydrophobic, while surface hydrophilic. This enables them for the complex formation lipophilic molecules. They have several applications in pharmaceutical field like solubility enhancers or building blocks larger drug delivery systems. On other hand, they numerous effects on cells biological barriers. In this review properties...
The resveratrol-induced cardiac protection was studied in Zucker obese rats. Rats were divided into five groups: group 1, lean control; 2, control (OC); 3, rats treated orally with 5 mg·kg −1 ·day of resveratrol (OR) for 2 wk; 4, received 10% glucose solution ad libitum 3 wk (OG); and 5, (OGR) during the 2nd 3rd wk. Body weight, serum glucose, insulin measured, then hearts isolated subjected to 30 min ischemia followed by 120 reperfusion. Heart rate, coronary flow, aortic developed pressure,...
Chrysin is a bioflavonoid that can be found in natural products such as honey and propolis, it possesses several biological effects antioxidant, anti-inflammatory, anti-cancer activity. However, poorly soluble water, its bioavailability limited. The aim of this research to investigate the chrysin solubilization capacity different β-cylcodextrin derivatives compare their activities. was complexed with β-cyclodextrin (βCD), hydroxypropyl-β-, (HPBCD) sulfobutylether-β-, (SBECD),...
Nowadays, polyethylene glycols referred to as PEGs are widely used in cosmetics, consumer care products, and the pharmaceutical industry. Their advantageous properties such chemical stability, low immunogenicity, high tolerability explain why applied many fields of formulations including parenteral, topical, ophthalmic, oral, rectal preparations also modern drug delivery systems. Given their extensive use, they considered a well-known group chemicals. However, number large-scale comparative...
Prior exposure to microenvironmental signals could fundamentally change the response of macrophages subsequent stimuli. It is believed that T helper-2 (Th2)-cell-type cytokine interleukin-4 (IL-4) and Toll-like receptor (TLR) ligand-activated transcriptional programs mutually antagonize each other, no remarkable convergence has been identified between them. In contrast, here, we show IL-4-polarized established a hyperinflammatory gene expression program upon lipopolysaccharide (LPS)...
Cyclodextrins, even the 6-membered α-cyclodextrin, are approved in various pharmacopoeias as pharmaceutical excipients for solubilizing and stabilizing drugs well controlling drug release. Recently α-cyclodextrin has also been marketed health food with beneficial effects on blood lipid profiles. However, concentration of used may be very high these cases, its toxic attributes have to seriously considered. The objective this study was investigate cytotoxicity various, differently substituted...
Cyclodextrins are widely used excipients for increasing the bioavailability of poorly water-soluble drugs. Their effect on drug absorption in gastrointestinal tract is explained by their solubility- and permeability-enhancement. The aims this study were to investigate penetration properties fluorescently labeled randomly methylated-beta-cyclodextrin (FITC-RAMEB) Caco-2 cell layer examine cellular entry cyclodextrins intestinal cells. permeability FITC-RAMEB through monolayers was very...
A recent study from our laboratory indicated the cardioprotective ability of tocotrienol-rich fraction (TRF) red palm oil. The present compared abilities different isomers tocotrienol against TRF as recently has been found to function a potent neuroprotective agent stroke. Rats were randomly assigned one following groups: animals given, by gavage, either 0.35%, 1%, or 3.5% for two periods time (2 4 wk) 0.03, 0.3, and 3 mg/kg body wt (alpha, gamma, delta) wk; control vehicle only. After 2 wk,...
Nowadays, the sorbates are third largest group of antimicrobial preservatives in food and pharmaceutical industries, following parabens benzoates whose safety is questioned by recent publications. A disadvantage their pH dependence, as effect greatly reduced alkaline environment. The main, widely used sorbate derivatives sorbic acid potassium sorbate, no esters involved current industrial application. We aimed to test whether capable extend spectrum original molecule while maintaining its...
Turmeric has been used for decades its antioxidant and anti-inflammatory effect, which is due to an active ingredient isolated from the plant, called curcumin. However, extremely poor water-solubility of curcumin often limits bioavailability drug. The aim our experimental work was improve solubility thus by developing self-nano/microemulsifying drug delivery systems (SN/MEDDS). Labrasol Cremophor RH 40 as nonionic surfactants, Transcutol P co-surfactant isopropyl myristate oily phase were...
The effects of kernel extract obtained from sour cherry ( Prunus cerasus) seed on the postischemic cardiac recovery were studied in isolated working rat hearts. Rats treated with various daily doses for 14 days, and hearts then subjected to 30 min global ischemia followed by 120 reperfusion. incidence ventricular fibrillation (VF) tachycardia (VT) fell their control values 92% 100% 50% (not significant) 58% significant), 17% P < 0.05), 25% 0.05) 10 mg/kg extract, respectively. Lower...
Anthocyanins have several beneficial effects, especially on inflammatory and oxidative conditions. The pro-inflammatory cytokines, tumor necrosis factor-α (TNF-α) interleukin-1β (IL-1β), induce damage in the intestinal barrier participate pathogenesis of chronic bowel diseases. A number fruits high anthocyanin contents with strong biological activity which can support protective actions. Sour cherry (Prunus cerassus) is one richest anthocyanins; it has content cyanidins. aim this study was...
Plants with high amounts of antioxidants may be a promising therapy for preventing and curing UV-induced oxidative skin damage. The objective this study was to verify the efficacy topical formulations containing dissolved suspended Silybum marianum extract against UVB-induced stress in guinea pig HaCaT keratinocytes. Herbal Transcutol HP (TC) sucrose-esters were incorporated as penetration enhancers creams. Biocompatibility compositions tested on HeLa cells keratinocytes vitro models....
Alpha-melanocyte-stimulating hormone (α-MSH) is a potent anti-inflammatory peptide with cytoprotective effect in various tissues. The present investigation demonstrates the ability of α-MSH to interact intestinal epithelial cell monolayers and mitigate inflammatory processes barrier. protective was studied on Caco-2 human monolayers, which were disrupted by exposure tumor necrosis factor-α interleukin-1β. barrier integrity assessed measuring transepithelial electric resistance (TEER)...