A5044434268- Immune cells in cancer
- Neurological disorders and treatments
- Epigenetics and DNA Methylation
- Language, Metaphor, and Cognition
- Genomics and Chromatin Dynamics
- EEG and Brain-Computer Interfaces
- Immune Cell Function and Interaction
- Epilepsy research and treatment
- Media Influence and Health
- Parkinson's Disease Mechanisms and Treatments
- GDF15 and Related Biomarkers
- Functional Brain Connectivity Studies
- Digital Games and Media
- Transcranial Magnetic Stimulation Studies
- Discourse Analysis in Language Studies
- Botulinum Toxin and Related Neurological Disorders
- Phagocytosis and Immune Regulation
- Creativity in Education and Neuroscience
- Educator Training and Historical Pedagogy
- Sleep and Wakefulness Research
- Advanced MRI Techniques and Applications
- Hungarian Social, Economic and Educational Studies
- Narrative Theory and Analysis
- RNA and protein synthesis mechanisms
- Metastasis and carcinoma case studies
Icahn School of Medicine at Mount Sinai
2024-2025
Semmelweis University
2024-2025
University of Szeged
2024
University of Pecs
2024
Johns Hopkins All Children's Hospital
2020-2024
Johns Hopkins University
2020-2024
National Institute of Menthal Health, Neurology and Neurosurgery - Nyírő Gyula Hospital
2024
Johns Hopkins Medicine
2020-2024
Tisch Hospital
2024
Országos Idegsebészeti Tudományos Intézet
2016-2022
Age is a major risk factor for cancer, but how aging impacts tumor control remains unclear. In this study, we establish that of the immune system, regardless age stroma and tumor, drives lung cancer progression. Hematopoietic enhances emergency myelopoiesis, resulting in local accumulation myeloid progenitor–like cells tumors. These are source interleukin (IL)–1⍺, which enhanced response. The age-associated decline DNA methyltransferase 3A IL-1⍺ production, disrupting IL-1 receptor 1...
Muscle regeneration is the result of concerted action multiple cell types driven by temporarily controlled phenotype switches infiltrating monocyte-derived macrophages. Pro-inflammatory macrophages transition into a that drives tissue repair through production effectors such as growth factors. This orchestrated sequence regenerative inflammatory events, which we termed regeneration-promoting program (RPP), essential for proper repair. However, it not well understood how specialized...
The impact of R-loops on the physiology and pathology chromosomes has been demonstrated extensively by chromatin biology research. progress in this field driven technological advancement R-loop mapping methods that largely relied a single approach, DNA-RNA immunoprecipitation (DRIP). Most DRIP protocols use experimental design was developed few laboratories, without paying attention to potential caveats might affect outcome RNA-DNA hybrid mapping. To assess accuracy utility technology, we...
Prior exposure to microenvironmental signals could fundamentally change the response of macrophages subsequent stimuli. It is believed that T helper-2 (Th2)-cell-type cytokine interleukin-4 (IL-4) and Toll-like receptor (TLR) ligand-activated transcriptional programs mutually antagonize each other, no remarkable convergence has been identified between them. In contrast, here, we show IL-4-polarized established a hyperinflammatory gene expression program upon lipopolysaccharide (LPS)...
Macrophages polarize into functionally distinct subtypes while responding to microenvironmental cues. The identity of proximal transcription factors (TFs) downstream from the polarization signals are known, but their activity is typically transient, failing explain long-term, stable epigenomic programs developed. Here, we mapped early and late changes interleukin-4 (IL-4)-induced alternative macrophage polarization. We identified TF, growth response 2 (EGR2), bridging transient gene...
Adipose-derived stem cells (ADSCs) play an important role in the differential capacity for excess energy storage between upper body abdominal (ABD) adipose tissue (AT) and lower gluteofemoral (GF) AT. We cultured ADSCs from subcutaneous ABD AT GF isolated eight women with fat distribution performed single-cell RNA sequencing. Six populations of were identified segregated according to their anatomical origin. The three ADSC subpopulations characterized by strong cholesterol/fatty acid (FA)...
Rapid eye movement (REM) sleep is an elusive neural state that associated with a variety of functions from physiological regulatory mechanisms to complex cognitive processing. REM periods consist the alternation phasic and tonic microstates differ in spontaneous evoked activity. Although previous studies indicate, cortical thalamocortical activity differs across microstates, characterization activity, particularly subcortical structures are critical initiation maintenance still limited...
Macrophage polarization is a process whereby macrophages develop specific phenotype and functional response to different pathophysiological stimuli tissue environments. In general, two main macrophage phenotypes have been identified: inflammatory (M1) alternatively activated (M2) characterized specifically by IL-1β IL-10 production, respectively. the cardiotoxin-induced skeletal muscle injury model bone marrow-derived (BMDMs) play central role in regulating repair. Bone monocytes arriving at...
S ummary . One group of Hungarian (N=29) and one Swedish (N=31) secondary school students read Franz Kafka's famous parable “Before the Law” several times, each reading being followed by recalling story stating how they had understood what meant. A limited number qualitatively different ways understanding were found these could be related to other in terms well captured meaning story. In some cases used we have called “reflective variation” their Reflective variation form “variation...
Abstract The infiltration and subsequent in situ subtype specification of monocytes to effector/inflammatory repair macrophages is indispensable for tissue upon acute sterile injury. However, the chromatin-level mediators regulatory events controlling this highly dynamic macrophage phenotype switch are not known. In study, we used a murine muscle injury model assess global chromatin accessibility gene expression dynamics infiltrating during physiological inflammation regeneration. We...
"Trained immunity" of innate immune cells occurs through a sequential two-step process where an initial pathogenic or sterile inflammatory trigger is followed by amplified response to later un-related secondary pathogen challenge. The memory effect mediated at least in part epigenetic modifications the chromatin landscape. Here, we investigated role modifier Setdb2 microbial (β-glucan) (Western-diet-WD/oxidized-LDL-oxLDL)-induced trained immunity macrophages. Using genetic mouse models and...
Rapid eye movement (REM) sleep is a fundamental state associated with diverse functions from elemental physiological processes to higher order neurocognitive functions. A growing body of research indicates that REM movements (phasic REM) differs periods without ocular activity (tonic) in terms spontaneous and evoked neural responses. Studies using auditory stimulation consistently observed enhanced responses tonic versus phasic REM, indicating external processing largely diminished when the...
Abstract Introduction: Chronic inflammation can contribute to growth and immune evasion of solid tumors, with multiple cytokines chemokines implicated in this process. We previously showed that disrupting the Th2 response systemically by blocking IL-4 signaling activate dendritic cells T effector generate a robust against tumor antigens pre-clinical lung cancer models (Maier, B., et al., A conserved dendritic-cell regulatory program limits anti-tumour immunity. Nature,...
Abstract Compound network dynamics in beta and gamma bands determine the severity of bradykinesia Parkinson’s disease. We explored its subthalamic stimulation related changes parallel with improvement complex hand movements. Thirty eight patients disease treated bilateral accomplished voluntary traced spiral drawing their more affected on a digital tablet. A 64 channel electroencephalography was recorded, low high power computed motor cortical sources at four levels. Subthalamic effective...
<title>Abstract</title> "Trained immunity" of innate immune cells occurs through a sequential two-step process where an initial pathogenic or sterile inflammatory trigger is followed by amplified response to later un-related secondary pathogen challenge. The memory effect mediated at least in part epigenetic modifications the chromatin landscape. Here, we investigated role modifier Setdb2 microbial (β-glucan) (Western-diet-WD/oxidized-LDL-oxLDL)-induced trained immunity macrophages. Using...
Monocyte-derived macrophages (mo-macs) drive immunosuppression in the tumor microenvironment (TME) and tumor-enhanced myelopoiesis bone marrow (BM) fuels these populations. Here, we performed paired transcriptome chromatin analysis over continuum of BM myeloid progenitors, circulating monocytes, tumor-infiltrating mo-macs mice patients with lung cancer to identify progenitor programs that fuel pro-tumorigenic mo-macs. Analyzing accessibility histone mark changes, show tumors prime for Nfe2l2...
BACKGROUNDPathophysiology of type 1 diabetes (T1D) is illustrated by pancreatic islet infiltration inflammatory lymphocytes, including CD8+ T cells; however, the molecular factors mediating their recruitment remain unknown. We hypothesized that single-cell RNA-sequencing (scRNA-Seq) analysis immune cell populations isolated from islets NOD mice captured gene expression dynamics providing critical insight into autoimmune pathogenesis.METHODSPancreatic sections human donors were investigated,...
Accumulation of fat above the waist is an important risk factor in developing obesity-related comorbidities independently BMI or total mass. Deciphering gene regulatory programs adipose tissue precursor cells within upper body abdominal (ABD) and lower gluteofemoral (GF) depots to understand their differential capacity for lipid accumulation, maturation, disease risk. Previous studies identified HOX transcript antisense intergenic RNA (HOTAIR) as a GF-specific lncRNA; however, its role...
Introduction Macrophages significantly contribute to the regulation of vessel formation under physiological and pathological conditions. Although angiogenesis-regulating role alternatively polarized macrophages is quite controversial, a growing number evidence shows that they can participate in later phases angiogenesis, including sprouting remodeling or regression. However, epigenetic transcriptional regulatory mechanisms controlling this angiogenesis-modulating program are not fully...
Tissue regeneration is orchestrated by macrophages that clear damaged cells and promote regenerative inflammation. How spatially adapt diversify their functions to support the architectural requirements of actively regenerating tissue remains unknown. In this study, we reconstructed dynamic trajectories myeloid isolated from acutely injured early-stage dystrophic muscles. We identified divergent subsets monocytes/macrophages dendritic (DCs) validated markers (e.g., GPNMB) transcriptional...
Abstract Tertiary lymphoid structures (TLS) are organized immune cell aggregates that arise in chronic inflammatory conditions. In cancer, TLS associated with better prognosis and enhanced response to immunotherapy, making these attractive therapeutic targets. However, the mechanisms regulating formation maintenance cancer incompletely understood. Using spatial transcriptomics multiplex imaging across various human tumors, we found an enrichment of mature dendritic cells (DC) expressing high...