A5077543350- Muscle Physiology and Disorders
- GDF15 and Related Biomarkers
- Nutrition and Health in Aging
Johns Hopkins University
2021
Johns Hopkins All Children's Hospital
2021
Muscle regeneration is the result of concerted action multiple cell types driven by temporarily controlled phenotype switches infiltrating monocyte-derived macrophages. Pro-inflammatory macrophages transition into a that drives tissue repair through production effectors such as growth factors. This orchestrated sequence regenerative inflammatory events, which we termed regeneration-promoting program (RPP), essential for proper repair. However, it not well understood how specialized...
This study explores the inflammatory response observed in pancreata and pancreatic lymph node (pLN) samples obtained throughout natural history of type 1 diabetes (T1D) including non-diabetic individuals autoantibody positive with high susceptibility using spatial transcriptomics (ST). Integration ST public single-cell RNA sequencing data enabled interrogation transcriptional alterations T1D pathogenesis across both tissues cellular scales. In pancreas, we global upregulation multiple...