A5052962131- Phagocytosis and Immune Regulation
- Blood properties and coagulation
- Erythrocyte Function and Pathophysiology
- Immune cells in cancer
- Tissue Engineering and Regenerative Medicine
- Adenosine and Purinergic Signaling
- Retinoids in leukemia and cellular processes
- Graphene and Nanomaterials Applications
- biodegradable polymer synthesis and properties
- Pancreatitis Pathology and Treatment
- Autophagy in Disease and Therapy
- Mesenchymal stem cell research
- Immune Cell Function and Interaction
- Adipokines, Inflammation, and Metabolic Diseases
- RNA Interference and Gene Delivery
- Tendon Structure and Treatment
- Cholesterol and Lipid Metabolism
- Platelet Disorders and Treatments
- COVID-19 Impact on Reproduction
- Nuclear Receptors and Signaling
- Bone Tissue Engineering Materials
- Pancreatic function and diabetes
- Nanoparticle-Based Drug Delivery
- Apelin-related biomedical research
- Venous Thromboembolism Diagnosis and Management
University of Debrecen
2015-2024
Hungarian Academy of Sciences
2005-2011
University of Rome Tor Vergata
2003
Tissue transglutaminase (TGase2) is a protein-crosslinking enzyme known to be associated with the in vivo apoptosis program. Here we report that could induced TGase2 -/- mice; however, clearance of apoptotic cells was defective during involution thymus elicited by dexamethasone, anti-CD3 antibody, or γ-irradiation, and liver after hyperplasia. The lack prevented production active transforming growth factor-β1 macrophages exposed cells, which required for up-regulation , accelerating deletion...
Macrophages acquire their capacity for efficient phagocytosis of apoptotic cells during differentiation from monocytes. The peroxisome proliferator-activated receptor gamma (PPARgamma) is highly up-regulated this maturation program. We report that addition PPARgamma antagonist human monocytes to macrophages significantly reduced the engulf neutrophils, but did not influence opsonized bacteria. Macrophage-specific deletion in mice also resulted decreased uptake cells. acted a dose-dependent...
Transglutaminase 2 (TG2) is an inducible transamidating acyltransferase that catalyzes Ca(2+)-dependent protein modifications. In addition to being enzyme, TG2 also serves as a G for several seven transmembrane receptors and acts co-receptor integrin β1 β3 integrins distinguishing it from other members of the transglutaminase family. ubiquitously expressed in almost all cell types compartments, present on surface gets secreted extracellular matrix via non-classical mechanisms. has been...
Abstract Efficient execution of apoptotic cell death followed by efficient clearance mediated professional macrophages is a key mechanism in maintaining tissue homeostasis. Removal cells usually involves three central elements: 1) attraction phagocytes via soluble “find me” signals, 2) recognition and phagocytosis surface-presenting “eat 3) suppression or initiation inflammatory responses depending on additional innate immune stimuli. Suppression inflammation both direct inhibition...
Abstract There have been significant developments in the use of siRNA silencing cancer-allied target proteins with substantial apoptotic effects. Nevertheless, challenges regarding delivery for cancer therapy remain a major concern taking these therapies successfully from laboratory to vivo studies. Biomaterials are defined traditionally as any material that is used either medical or dental applications contact host cells form, such drug carrier device, prosthesis towards replacement damaged...
Abstract Skeletal muscle regeneration following injury results from the proliferation and differentiation of myogenic stem cells, called satellite located beneath basal lamina fibers. Infiltrating macrophages play an essential role in process partly by clearing necrotic cell debris, producing cytokines that guide myogenesis. are at beginning pro-inflammatory, but phagocytosis dead cells induces a phenotypic change to become healing regulate inflammation, myoblast fusion growth, fibrosis,...
Previous work in our laboratory has shown that transglutaminase 2 (TG2) acting as a coreceptor for integrin β3 is required proper phagocytosis of apoptotic cells. In the absence TG2, systemic lupus erythematosus-like autoimmunity develops mice, similarly to other mice characterized by deficiency clearance this study, we demonstrate increasing TG2 expression alone wild-type macrophages not sufficient enhance engulfment. However, during engulfment, lipid content cells triggers lipid-sensing...
Macrophage polarization is a process whereby macrophages develop specific phenotype and functional response to different pathophysiological stimuli tissue environments. In general, two main macrophage phenotypes have been identified: inflammatory (M1) alternatively activated (M2) characterized specifically by IL-1β IL-10 production, respectively. the cardiotoxin-induced skeletal muscle injury model bone marrow-derived (BMDMs) play central role in regulating repair. Bone monocytes arriving at...
Abstract Tissue transglutaminase (TG2) is a protein cross-linking enzyme known to be expressed by hepatocytes and induced during the in vivo hepatic apoptosis program. TG2 also G that mediates intracellular signaling alpha-1b-adrenergic receptor (AR) liver cells. Fas/Fas ligand interaction plays crucial role various diseases, administration of agonistic anti-Fas antibodies mice causes both disseminated endothelial cell fulminant failure. Here we report an intraperitoneal dose antibodies,...
Background The application of polymeric materials in medical industry has grown drastically the last two decades due to their various advantages compared existing materials. present research work emphases on sol-gel technique formulate polymethyl methyl acrylate/polystyrene/silica composite membrane. Methods characteristic was investigated through modern state art instrumentation. Results functional groups attached polymer absorbed by FTIR. FTIR spectrum confirm that blend mixed thoroughly...
One of the major roles professional phagocytes is removal dead cells in body. We know less about clearance necrotic than apoptotic cell phagocytosis, despite fact that both types need to be cleared together and appear often pathological settings. In present study, we examined phagocytosis heat‐ or H 2 O ‐killed thymocytes by mouse bone marrow‐derived macrophages ( BMDM s) vitro found two are engulfed at equal efficiency compete with each other when added s. Phagocytosis was decreased (a)...
Dietary food, depending on timing, amount and composition can influence gene expression in various tissues. Here, we investigated the effect of high-fat meal diets different compositions pattern human skeletal muscle. Gene data muscle samples from volunteers prior 4 h after consumption high lipid-containing consisting either saturated-, monounsaturated- or polyunsaturated fatty acids were downloaded public repository. List 843 differently expressed genes (DEGs) was generated. Functional...