A5031058606- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Supramolecular Chemistry and Complexes
- Molecular Sensors and Ion Detection
- Crystallography and molecular interactions
- Chemical Synthesis and Analysis
- Carbohydrate Chemistry and Synthesis
- Soil erosion and sediment transport
- Supramolecular Self-Assembly in Materials
- Click Chemistry and Applications
- Geology and Paleoclimatology Research
- Hydrology and Sediment Transport Processes
- Paleontology and Stratigraphy of Fossils
- Geological and Geophysical Studies Worldwide
- Surfactants and Colloidal Systems
- Lanthanide and Transition Metal Complexes
- Mass Spectrometry Techniques and Applications
- Analytical Chemistry and Chromatography
- Geological formations and processes
- Metal-Organic Frameworks: Synthesis and Applications
- Breast Cancer Treatment Studies
- Advanced biosensing and bioanalysis techniques
- Drug Solubulity and Delivery Systems
- Water Quality Monitoring Technologies
- Organophosphorus compounds synthesis
Centre National de la Recherche Scientifique
2015-2025
Université Claude Bernard Lyon 1
2015-2025
École d'Ingénieurs en Chimie et Sciences du Numérique
2012-2025
Institut de Chimie et Biochimie Moléculaires et Supramoléculaires
2015-2025
Hirslanden Clinique Cecil
2006-2025
Environnement, ville, société
2013-2024
Institut National des Sciences Appliquées de Lyon
2012-2023
Université Lumière Lyon 2
2022-2023
Institut d'Etudes Politiques de Paris
2021
Institute of Materials and Environmental Chemistry
2020
The authors propose a novel method of estimating the nonlinear elastic properties based on analysis arterial diameter against pressure curves derived from ultrasonic and photoplethysmographic measurements. An echo tracking device has been developed that allows continuous recording internal peripheral arteries. It measures 300 times per second with resolution 2.5 mu m. This system is linked to commercially available light-plethysmograph which continuously records finger (0.25 kPa accuracy)....
The goal of this study was to investigate whether the elastic behavior conduit arteries humans or rats is altered as a result concomitant hypertension. Forearm arterial cross-sectional compliance-pressure curves were determined noninvasively by means high precision ultrasonic echo-tracking device coupled photoplethysmograph (Finapres system) allowing simultaneous diameter and finger blood pressure monitoring. Seventeen newly diagnosed hypertensive patients with humeral 163/103 +/- 4.4/2.2 mm...
The elusive questions how arginine-rich sequences allow peptides and proteins to penetrate cells or form voltage-gated ion channels are controversial topics of current scientific concern. possible contributions exchangeable counterions these puzzling processes remain underexplored. objective this report is clarify scope limitations certain counteranions modulate cellular uptake anion carrier activity oligo/polyarginines. key finding that the efficiency counteranion activators depends...
We report that the efflux of 5(6)-carboxyfluorescein anions from neutral egg yolk phosphatidylcholine vesicles is mediated by oligo/polyarginines only in presence activating amphiphilic anions. Screening anion activators reveals best synergism for carboxylates (fullerene ≫ calix[4]arene ≈ coronene > pyrene calix[6]arene alkyl), whereas sulfates show less satisfactory activation despite often lower effective concentrations. The analogous alcohols and one diphosphate were inactive. These...
The water soluble p-sulfonatocalix[n]arenes (n = 4, 6 and 8) (14, 16 18) show glycosylaminoglycan (GAG) mimicry, being both active antithrombotics modulators of lysyloxidase activity. In order to understand how these synthetic receptors interact with GAG receptor sequences, we have undertaken a study thermodynamically characterize the binding dipeptides tripeptides bearing lysine or arginine residues by 14, 18 in aqueous buffer at pH 8.0 298.15 K. association constants, enthalpies entropies...
Cyclodextrins, even the 6-membered α-cyclodextrin, are approved in various pharmacopoeias as pharmaceutical excipients for solubilizing and stabilizing drugs well controlling drug release. Recently α-cyclodextrin has also been marketed health food with beneficial effects on blood lipid profiles. However, concentration of used may be very high these cases, its toxic attributes have to seriously considered. The objective this study was investigate cytotoxicity various, differently substituted...
Reversed-phase high-performance liquid chromatography (Separon SGX C 18, UV detection at 254 nm and acetonitrile–water–trifluoroacetic acid (70∶30∶0.5, v/v), methanol–water–trifluoroacetic (3∶97∶0.5, v/v) as mobile phases) was applied to the study of host–guest complexation p-sulfonatocalix[4]arene (SC[4]A) with amino acids guests in phase. It established that formation inclusion complexes results changes retention times acids. Stability constants were determined. The variations stability...
We present an integrated proteomics platform designed for performing differential analyses. Since reproducible results are essential comparative studies, we explain how improved reproducibility at every step of our laboratory processes, e.g. by taking advantage the powerful information management system developed. The capacity is validated detecting known markers in a real sample and spiking experiment. introduce innovative two-dimensional (2-D) plot displaying identification combined with...
On 24-25 October 2005 a cluster of five haemolytic uraemic syndrome (HUS) cases was reported in southwest France. An investigation undertaken to identify the outbreak source and implement control measures. Cases were defined as individuals with HUS or diarrhoea isolation Escherichia coli O157:H7 stools positive antibody response E. O157 lipopolysaccharide, resident France symptom onset after 19 September 2005. Sixty-nine identified patients had between 5 3 November 2005, including 17 HUS....
Abstract Treatment of 3‐O‐benzyl‐1, 2‐O‐isopropylidene‐3‐O‐methyl‐α‐ D ‐ xylo ‐pentodialdlo‐1,4‐furanose and 2,5‐anhydro‐3,4‐O‐isopropylidene‐ aldehydo ‐ribose with moderately stable phosphonium ylides led to the corresponding terminal‐unsaturated sugars obtained as a mixture cis trans isomers. The cis:trans ratios were determined by 1 H‐NMR. (or) GLC. They showed that steric factors play an important role in control stereochemistry these reactions.
Abstract 1.3‐dipolar cycloaddition of alkenes (or alkynes) on sugars‐nitriloxides and nitrilimines led respectively to 3‐glycosyl‐isoxazolines isoxazoles) 3‐glycosyl‐pyrazolines pyrazoles). 5‐glycosyl‐isoxazolines were similarly prepared from arylnitriloxides α‐ or ω‐unsaturated sugars. These new C‐glycosides are potential antiviral anti‐tumor agents.
The biological activities of the calix[n]arenes have been extensively reported on, with regard to various forms life ranging from self-replicating systems, such as, viruses, through bacteria, fungi and mammalian cells human beings. This article reviews more than one hundred different classified according their effects directly observed on living species. These macrocyclic molecules as detoxifying agents, having antibacterial, antiviral, anticoagulant, anticancer, antifungal activities,...
We report on the U‐shaped folding of flexible guest molecules medicinal interest upon their inclusion into macrocyclic cavity p‐sulfonato‐calix[4]arene in aqueous media. Alexidine and pentamidine are FDA‐approved drug compounds currently rediscovered as potent membrane‐targeting antibiotic adjuvants helping restore activity against multidrug resistant bacteria pathogens. have adopted host‐guest crystal engineering approach to study these drugs with a view potential supramolecular...
Aortic valve reconstruction with autologous glutaraldehyde-fixed pericardium (Ozaki procedure) represents an alternative to conventional prosthetic replacement, allowing excellent haemodynamic outcome. We report two cases of Subclinical Leaflet Thrombosis (SLT) at 12 and 23 months follow-up. Anticoagulation was initiated, later echocardiography showed mobility improvement. SLT is well documented for bioprosthetic valve. To our knowledge this the first Ozaki procedure in adult population....