A5033870994- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- Atherosclerosis and Cardiovascular Diseases
- Celiac Disease Research and Management
- Dermatology and Skin Diseases
- Systemic Sclerosis and Related Diseases
- Rheumatoid Arthritis Research and Therapies
- Immunodeficiency and Autoimmune Disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Asthma and respiratory diseases
- Urticaria and Related Conditions
- Abdominal Trauma and Injuries
- Microscopic Colitis
- Diabetes and associated disorders
- Inflammatory Bowel Disease
- Cytokine Signaling Pathways and Interactions
- Allergic Rhinitis and Sensitization
- Adenosine and Purinergic Signaling
- Eosinophilic Esophagitis
- Protein Kinase Regulation and GTPase Signaling
- Pediatric health and respiratory diseases
- Digestive system and related health
University of Debrecen
2015-2024
Hungarian Academy of Sciences
2006-2009
Semmelweis University
2009
University of Kentucky
2006-2007
Université de Montréal
1995
<b>Objective</b> To evaluate the feasibility and diagnostic accuracy of screening for coeliac disease by rapid detection IgA antibodies to tissue transglutaminase performed in primary care. <b>Design </b>District nurses screened 6 year old children using antibody testing finger prick blood. They also collected capillary blood samples laboratory determination IgG endomysium transglutaminase. Children with positive test results were directly sent biopsy small intestine. <b>Setting </b>Primary...
BACKGROUND Antibodies to Saccharomyces cerevisiae (S. cerevisiae) (ASCA) and porin protein-C of Escherichia coli (anti-OmpC) are associated with disease phenotype may be diagnostic importance in inflammatory bowel diseases (IBD). Our aim was determine whether a panel new antibodies against bacterial proteins carbohydrates could help differentiate among the various forms IBD, they were particular clinical manifestations Hungarian cohort IBD patients. METHODS Six hundred fifty-two...
Objective. Studies indicate that ankylosing spondylitis (AS), as well rheumatoid arthritis, may be associated with accelerated atherosclerosis and vascular disease. We assessed endothelial dysfunction, carotid atherosclerosis, aortic stiffness in AS context clinical laboratory measurements. Methods. Forty-three patients 40 matched healthy controls were studied. common intima-media thickness (ccIMT), flow-mediated vasodilation (FMD), pulse-wave velocity (PWV) association age, disease...
The aim of the present study was to describe subsets cells with regulatory properties in primary Sjögren's syndrome (pSS), and correlate these cell populations clinical symptoms. Among 32 investigated patients, 23 had extraglandular manifestations (EGMs), while nine only glandular Twenty healthy individuals served as controls. percentages natural killer (NK), T (NK T), interleukin (IL)-10 producing type 1 (Tr1) CD4(+)CD25(+) (T(reg)) were determined by flow cytometry serum cytokine levels...
Patients with celiac disease, who often carry human leukocyte antigen-DR3;DQ2, are prone to inadequate response hepatitis B immunization. We evaluated vaccine in relation disease activity and whether previous treatment a gluten-free diet influences the achievement of protective antibody titers.We studied 128 children adolescents 113 age-matched control subjects. Twenty-two patients were prospectively immunized after diagnosis during dietary (group 1). A total 106 2) subjects received...
Objectives: The aim of this study was to evaluate a wide spectrum peripheral immune-competent cell types, reflecting overall disturbances in immune homeostasis, characteristic systemic sclerosis (SSc). We also assessed visceral organ involvement and evaluated the relationship between proportions clinical symptoms disease.
Regulatory T cells (Tregs) have an essential role in tolerance and immune regulation. However, few controversial data been published to date on the number of these atopic dermatitis (AD).To investigate CD4+CD25+FOXP3+ Tregs interleukin 10-producing regulatory type 1 (Tr1) patients with AD.Peripheral blood skin biopsy samples from atopy patch test (APT)-positive acute- chronic-phase AD were investigated. Immunohistochemistry was applied identify skin, while flow cytometry used detect...
Severe cases of COVID-19 are characterized by an inflammatory burst, which is accompanied multiorgan failure. The elderly population has higher risk for severe or fatal outcome COVID-19. Inflammatory mediators facilitate the immune system to combat viral infection producing antibodies against antigens. Several studies reported that pro-inflammatory state and tissue damage in also promotes autoimmunity autoantibody generation. We hypothesized a subset these autoantibodies targets cardiac Here...
Abnormalities of regulatory T cells may play an important role in the loss self-tolerance, which is a major characteristic lupus. The objective this study was to determine ratio and number natural CD4+CD25highFoxp3+ inducible CD4+IL-10+ lupus patients search correlation with disease activity. Seventy-two Hungarian were enrolled study. Fourty-one age- sex matched healthy donors served as controls. Flow cytometry used for quantification CD4+CD25high Foxp3+ (nTreg) (iTreg) cells. (3.06 +/-...
Pancreatic autoantibodies (PAB) and goblet cell (GAB) are specific for Crohn's disease (CD) ulcerative colitis (UC), but the sensitivity alone is low. Conventional antibodies carbohydrates (glycans) associated with phenotype may be of diagnostic importance in inflammatory bowel (IBD). Our aim was to determine accuracy PAB GAB as well study relevant phenotype-serotype associations.A Hungarian cohort 1092 subjects, including 689 well-characterized, unrelated IBD patients (CD: 579, m/f ratio:...
To describe how certain peripheral immune parameters reflect the inflammatory alterations in patients with primary APS.Twenty-eight newly diagnosed APS were studied. The control group included 26 stable coronary disease and 38 healthy individuals. Peripheral blood lymphocyte subgroups quantified, intracellular cytokines measured by flow cytometry, soluble auto-antibodies assessed using ELISA. Endothelial dysfunction was evaluated measuring endothelium-dependent (flow-mediated; FMD)...
Coronavirus disease 2019 (COVID-19) has a high mortality in elderly patients with pre-existing cardiovascular diseases. The cellular receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the angiotensin-converting enzyme (ACE2), thereby implicating link between diseases and SARS-CoV-2 susceptibility. Aortic stenosis (AS) represents chronic inflammatory state complications elderly, prime condition for COVID-19 mortality. circulating ACE2 levels were measured 111 AS...
SUMMARY The aim of this study was to evaluate the prevalence IgG, IgA and IgM anti-β2-GPI antibodies in anti-phospholipid syndrome (APS), establish clinical significance type compared with other isotypes. Anti-β2-GPI were measured sera 70 patients by solid-phase enzyme immunoassay γ-irradiated polystyrene plates coated human purified β2-GPI. Thirty-three out classified as having APS: three them had primary, 30 secondary APS related systemic lupus erythematosus (SLE). remaining 37 SLE without...
Journal Article Significant correlation between the CD63 assay and histamine release in chronic urticaria Get access A. Szegedi, Szegedi Department of Dermatology 3rd Internal Medicine, Medical Health Science Centre, University Debrecen, 98 Nagyerdei str., Debrecen 4012, Hungary Andrea Szegedi. E‐mail: aszegedi@jaguar.dote.hu Search for other works by this author on: Oxford Academic Google Scholar B. Irinyi, Irinyi M. Gál, Gál J. Hunyadi, Hunyadi K. Dankó, Dankó E. Kiss, Kiss S. Sipka, Sipka...
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by increased pathologic autoantibody production. A decrease in the number of CD4+CD25highFoxP3+ regulatory T cells can play key role loss tolerance to self antigens. Our aim was determine absolute peripheral 44 patients with SLE, furthermore, measure changes 5 severe SLE treated repeated plasmapheresis for 4–6 days comparison activity (SLEDAI). Percent were measured flow cytometry. The significantly decreased...
Objectives. Circulating IgG antibodies to oxidized low-density lipoprotein (anti-oxLDL) have been implicated in the development of atherosclerotic plaques. In this study, we investigated prognostic value anti-oxLDL patients with acute coronary syndrome (ACS). Methods. total 54 ACS and 41 matched healthy controls were involved prospective study. Serum levels assessed by ELISA. Results. Higher found versus (22.8 ± 23.3 vs. 7.5 5.27 EU/ml, p < 0.0001). concentrations significantly higher...
IL-6 is a pro-inflammatory cytokine which has many well-defined effects. Its synthesis and release from mononuclear cells of drug-sensitized patients was related before to in vitro drug-allergy diagnostics but not yet been studied detail.The specific preformed peripheral blood (PBMC) after 20 minutes incubation with 0.15-0.5 μM pure drugs measured two groups suspected donors (159) respective controls (48). IL-6, TNF-alpha, IL-2, IL-4, IFN-gamma have cell supernatants by ELISA or cytometric...