A5103099830- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Cardiac electrophysiology and arrhythmias
- Heart Failure Treatment and Management
- Cardiac pacing and defibrillation studies
- Ion channel regulation and function
- Cardiac Imaging and Diagnostics
- Sport and Mega-Event Impacts
- Cardiac Arrhythmias and Treatments
- Cardiac Fibrosis and Remodeling
- Hungarian Social, Economic and Educational Studies
- Cardiac Structural Anomalies and Repair
- Redox biology and oxidative stress
- Electrolyte and hormonal disorders
- Nitric Oxide and Endothelin Effects
- Cardiovascular Disease and Adiposity
- Congenital Heart Disease Studies
- Cardiac Valve Diseases and Treatments
- Cardiovascular Health and Disease Prevention
- Diet and metabolism studies
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Effects of Exercise
- SARS-CoV-2 and COVID-19 Research
- Blood Pressure and Hypertension Studies
- Long-Term Effects of COVID-19
University of Debrecen
2015-2025
Hospital de São João
2011
Universidade do Porto
2011
Universidade Metodista de São Paulo
2010
Amsterdam UMC Location Vrije Universiteit Amsterdam
2005-2010
Vrije Universiteit Amsterdam
2008
OLVG
2007
Maastricht University
2007
GGD Amsterdam
2006
Vanderbilt University Medical Center
2005
Diastolic heart failure (DHF) currently accounts for more than 50% of all patients. DHF is also referred to as with normal left ventricular (LV) ejection fraction (HFNEF) indicate that HFNEF could be a precursor reduced LVEF. Because improved cardiac imaging and because widespread clinical use plasma levels natriuretic peptides, diagnostic criteria needed updated. The diagnosis requires the following conditions satisfied: (i) signs or symptoms failure; (ii) mildly abnormal systolic LV...
Excessive diastolic left ventricular stiffness is an important contributor to heart failure in patients with diabetes mellitus. Diabetes presumed increase through myocardial deposition of collagen and advanced glycation end products (AGEs). Cardiomyocyte resting tension also elevates stiffness, especially normal ejection fraction (LVEF). The contribution fibrosis, AGEs, cardiomyocyte was assessed diabetic or reduced LVEF.Left endomyocardial biopsy samples were procured 28 LVEF 36 LVEF, all...
To support the clinical distinction between systolic heart failure (SHF) and diastolic (DHF), left ventricular (LV) myocardial structure function were compared in LV endomyocardial biopsy samples of patients with failure.Patients hospitalized for worsening classified as having SHF (n=22; ejection fraction (EF) 34+/-2%) or DHF LVEF 62+/-2%). No patient had coronary artery disease evidence infiltrative inflammatory disease. More a history arterial hypertension obese. Biopsy analyzed...
Heart failure with preserved left ventricular (LV) ejection fraction (EF) is increasingly recognized and usually referred to as diastolic heart (DHF). Its pathogenetic mechanism remains unclear, partly because of a lack myocardial biopsy material. Endomyocardial samples obtained from DHF patients were therefore analyzed for collagen volume (CVF) sarcomeric protein composition compared control samples. Single cardiomyocytes isolated these assess cellular contractile performance.DHF (n=12) had...
High diastolic stiffness of failing myocardium results from interstitial fibrosis and elevated resting tension (F(passive)) cardiomyocytes. A shift in titin isoform expression N2BA to N2B isoform, lower overall phosphorylation titin, a can raise F(passive) In left ventricular biopsies heart failure (HF) patients, aortic stenosis (AS) controls (CON), we therefore related isolated cardiomyocytes isoforms isoforms. Biopsies were procured by transvascular technique (44 HF, 3 CON),...
Background: The use of urinary sodium to guide diuretics in acute heart failure is recommended by experts and the most recent European Society Cardiology guidelines. However, there are limited data support this recommendation. ENACT-HF study (Efficacy a Standardized Diuretic Protocol Acute Heart Failure) investigated feasibility efficacy standardized natriuresis-guided diuretic protocol patients with signs volume overload. Methods: was an international, multicenter, open-label, pragmatic,...
Background— Aortic stenosis (AS) and diabetes mellitus (DM) are frequent comorbidities in aging populations. In heart failure, DM worsens diastolic left ventricular (LV) dysfunction, thereby adversely affecting symptoms prognosis. Effects of on LV function were therefore assessed aortic stenosis, underlying myocardial mechanisms identified. Methods Results— Patients referred for valve replacement subdivided into patients with AS no (AS; n=46) (AS-DM; n=16). Preoperative Doppler...
It was shown recently that angiotensin-converting enzyme activity is limited by endogenous inhibition in vivo, highlighting the importance of angiotensin II (ACE2) elimination. The potential contribution ACE2 to cardiovascular disease progression addressed. Serum activities were measured different clinical states (healthy, n=45; hypertensive, n=239; heart failure (HF) with reduced ejection fraction (HFrEF) n=141 and HF preserved (HFpEF) n=47). significantly higher hypertensive patients...
Severe cases of COVID-19 are characterized by an inflammatory burst, which is accompanied multiorgan failure. The elderly population has higher risk for severe or fatal outcome COVID-19. Inflammatory mediators facilitate the immune system to combat viral infection producing antibodies against antigens. Several studies reported that pro-inflammatory state and tissue damage in also promotes autoimmunity autoantibody generation. We hypothesized a subset these autoantibodies targets cardiac Here...
Abstract Aims Classifying patients as responders or non‐responders to cardiac resynchronization therapy (CRT) has been recently challenged, suggesting that preventing heart failure (HF) progression may also provide survival benefits. We assessed a novel classification based on echocardiographic left ventricular (LV) reverse remodelling and the occurrence of acute HF hospitalization (HHF) sustained arrhythmia (VA) within 1‐year post‐CRT. Methods results Patients implanted with CRT...
A szívelégtelenség (SzE) napjaink egyik legjelentősebb népegészségügyi problémája. megőrzött ejekciós frakciójú SzE (HFpEF) egy igen heterogén kórkép, amelyet normális vagy közel bal kamrai frakció, diasztolés diszfunkció és emelkedett töltőnyomás jellemez. HFpEF prognózisa hasonló a csökkent SzE-hez (HFrEF), azonban kezelése személyre szabott megközelítést igényel. Ezen összefoglaló közlemény célja, hogy áttekintse HFpEF-fel kapcsolatos legújabb ismereteket: különböző fenotípusokat,...
Peroxynitrite-mediated myocardial protein nitration has been associated with a depressed cardiac pump function. In the present study, an attempt was made to elucidate molecular background of peroxynitrite-evoked alterations in human myocardium.Isometric force generation measured permeabilized ventricular myocytes and biochemical methods were employed identify proteins affected by peroxynitrite-induced nitrotyrosine formation.The maximal Ca(2+)-activated isometric (pCa=4.75) decreased zero...
Objective: In human heart failure β-adrenergic-mediated protein kinase A (PKA) activity is down-regulated, while C (PKC) up-regulated. PKC-mediated myofilament phosphorylation might be detrimental for contractile function in cardiomyopathy. This study was designed to reveal the effects of PKC on myocardium under basal conditions and upon modulation by PKA phosphatases.
Left ventricular (LV) myocardial structure and function differ in heart failure (HF) with normal (N) reduced (R) LV ejection fraction (EF). This difference could underlie an unequal outcome of trials β-blockers LVEF (HFNEF) (HFREF) mixed results observed HFNEF positive HFREF. To investigate whether have distinct effects HFREF, structure, cardiomyocyte function, protein composition were compared HFREF patients without or β-blockers. Patients, free coronary artery disease, divided into β−HFNEF...
Although acute heart failure (AHF) with volume overload is treated loop diuretics, their dosing and type of administration are mainly based upon expert opinion. A recent position paper from the Heart Failure Association (HFA) proposed a step-wise pharmacologic diuretic strategy to increase response achieve rapid decongestion. However, no study has evaluated this protocol prospectively.
Activation of the β-adrenergic receptor (βAR) pathway is main mechanism heart to increase cardiac output via protein kinase A (PKA)-mediated phosphorylation cellular target proteins, and perturbations therein may contribute dysfunction in failure. In present study a comprehensive analysis was made mediators βAR pathway, myofilament properties structure patients with idiopathic (IDCM; n = 13) ischemic (ISHD; 10) cardiomyopathy comparison non-failing hearts (donor; for following parameters:...
Abstract Aims The aim of the study was to assess incidence and predictive factors development heart failure with improved ejection fraction (HFimpEF) category during a 1 year follow‐up period in reduced (HFrEF) patient population managed outpatient clinic. Methods results evaluated data from patients enrolled Hungarian Heart Failure Registry (HHFR). HFimpEF after were assessed group who had HFrEF at baseline. We predictors relation time since diagnosis diagnosed within 3 months, between...
This study sought to characterize the relation between oxidation of protein sulfhydryl (SH) groups and Ca2+-activated force production in human myocardium. Triton-permeabilized left ventricular cardiomyocytes from donor hearts were exposed an oxidative (2,2'-dithiodipyridine, DTDP) agent vitro, changes isometric force, its Ca2+ sensitivity, cross-bridge-sensitive rate constant redevelopment at saturating [Ca2+] (k(tr,max)), SH monitored. DTDP (0.1-10 mM for 2 min) oxidized myocardial...
Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium most commonly caused by mutations in sarcomeric genes. We aimed to perform nationwide large-scale genetic analysis previously unreported, representative HCM cohort Hungary. A total 242 consecutive index patients (127 men, 44 ± 11 years) were studied with next generation sequencing using custom-designed gene-panel comprising 98 cardiomyopathy-related 90 (37%) carried pathogenic/likely pathogenic (P/LP) variants. The...
Abstract: We characterized the Ca 2+ -sensitizing and phosphodiesterase (PDE)-inhibitory potentials of levosimendan enoximone to assess their contributions positive inotropic effects these drugs. In guinea pig hearts perfused in working-heart mode, maximal increase cardiac output (55%, P < 0.05) was attained at 50 nM levosimendan. The corresponding value for (36%) significantly smaller ( observed a higher concentration (500 nM). permeabilized myocyte-sized preparations evoked 55.8 ± 8%...
The increase in Ca(2+) sensitivity of isometric force development along with sarcomere length (SL) is considered as the basis Frank-Starling law heart, possibly involving regulation cross-bridge turnover kinetics. Therefore, dependencies production and cross-bridge-sensitive rate constant redevelopment (k(tr)) were determined at different SLs (1.9 2.3 mum) isolated human, murine, porcine permeabilized cardiomyocytes. k(tr) was also presence 10 mM inorganic phosphate (P(i)), which interfered...