A5015748466- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Cardiac Imaging and Diagnostics
- Cardiovascular Disease and Adiposity
- Cardiac electrophysiology and arrhythmias
- Ultrasound in Clinical Applications
- Ultrasound and Hyperthermia Applications
- Williams Syndrome Research
- Congenital heart defects research
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Structural Anomalies and Repair
- Mitochondrial Function and Pathology
- Galectins and Cancer Biology
- Infrared Thermography in Medicine
- RNA Research and Splicing
- Sports injuries and prevention
- Coronary Artery Anomalies
- Advanced X-ray and CT Imaging
- Blood Pressure and Hypertension Studies
- Cardiac Arrhythmias and Treatments
- Coronary Interventions and Diagnostics
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
University of Szeged
2017-2025
Azienda Ospedaliero-Universitaria Careggi
2022-2024
University of Florence
2021
Istituto di Fisiologia Clinica
2019
Fatebenefratelli Hospital
2019
Université Claude Bernard Lyon 1
2017
Assistance Publique – Hôpitaux de Paris
2017
Hôpital Bichat-Claude-Bernard
2017
With stress echo (SE) 2020 study, a new standard of practice in imaging was developed and disseminated: the ABCDE protocol for functional testing within beyond CAD. fruit SE 2020, is seed 2030, which articulated 12 projects: 1-SE coronary artery disease (SECAD); 2-SE diastolic heart failure (SEDIA); 3-SE hypertrophic cardiomyopathy (SEHCA); 4-SE post-chest radiotherapy chemotherapy (SERA); 5-Artificial intelligence evaluation (AI-SEE); 6-Environmental echocardiography air pollution (ESTER);...
Abstract Background The left ventricular (LV) hypercontractile phenotype (HP) plays a critical role in hypertrophic cardiomyopathy (HCM) and is usually identified with the outflow tract gradient (LVOTG). Purpose To assess systemic coronary hemodynamic profile associated HP increased LV elastance (also known as force) at rest patients HCM. Methods We enrolled 1248 HCM (age 50 ± 15 years, 798 males, 64%) ejection fraction (EF) ≥50%, referred for transthoracic echocardiography (TTE) 14...
Genetic counselling and genetic testing in hypertrophic cardiomyopathy (HCM) represent an integral part of the diagnostic algorithm to confirm diagnosis, distinguish it from phenocopies, suggest tailored therapeutic intervention strategies. Additionally, they enable cascade family. With implementation Next Generation Sequencing technologies (NGS), interpretation data has become more complex. In this regard, cardiologists play a central role, aiding geneticists correctly evaluate...
Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium most commonly caused by mutations in sarcomeric genes. We aimed to perform nationwide large-scale genetic analysis previously unreported, representative HCM cohort Hungary. A total 242 consecutive index patients (127 men, 44 ± 11 years) were studied with next generation sequencing using custom-designed gene-panel comprising 98 cardiomyopathy-related 90 (37%) carried pathogenic/likely pathogenic (P/LP) variants. The...
Background: Nonalcoholic fatty pancreas and liver disease (NAFPD NAFLD) pericardial adipose tissue (PAT) are often associated with type 2 diabetes mellitus (T2DM). Our aim was to evaluate the incidence rate of NAFLD NAFPD, PAT size, effect metformin treatment on NAFLD, in new-onset T2DM (NODM). Methods: Seventeen patients NODM 10 subjects used as a control group were involved study. Computed tomography (CT) laboratory tests performed before beginning therapy 4 months afterward. amount fat...
We aimed to assess feasibility and functional correlates of left atrial volume index (LAVI) changes during exercise stress echocardiography (ESE).ESE on a bike or treadmill was performed in 363 patients with heart failure preserved ejection fraction (HFpEF, n = 173), reduced (HFrEF, 59), hypertrophic cardiomyopathy (HCM, 131). The LAVI stress-rest increase ≥6.8 ml/m2 defined as dilation.LAVI measurements were feasible 100%. did not change HFrEF being at rest 32 (25-45) vs 36 (24-54) ml/m2, P...
B-lines detected by lung ultrasound (LUS) during exercise stress echocardiography (ESE), indicating pulmonary congestion, have not been systematically evaluated in patients with hypertrophic cardiomyopathy (HCM).To assess the clinical, anatomical and functional correlates of congestion elicited HCM.We enrolled 128 HCM (age 52 ± 15 years, 72 males) consecutively referred for ESE (treadmill 46, bicycle 82 patients) 10 quality-controlled centers from 7 countries (Belgium, Brazil, Bulgaria,...
Background: Sympathetic dysfunction can be evaluated by heart rate reserve (HRR) with exercise test. Objectives: To determine the value of HRR in predicting outcome patients hypertrophic cardiomyopathy (HCM). Methods: We enrolled 917 HCM (age = 49 ± 15 years, 516 men) assessed stress echocardiography (ESE) 11 centres. ESE modality was semi-supine bicycle 51 (6%), upright 476 (52%), and treadmill 390 (42%). During ESE, we left ventricular outflow tract obstruction (LVOTO), stress-induced new...
Abstract Background The left ventricular (LV) force, also known as elastance, serves a load-independent indicator of contractility and can be noninvasively assessed through echocardiography. In hypertrophic cardiomyopathy (HCM), the heightened presence active state myosin heads results in an increased LV force. Purpose To assess prognostic value elastance at rest patients with HCM. Methods We enrolled 1420 HCM (age 50±16 years, 907 males, 64%) ejection fraction (EF) ≥50%, referred for...
Atrial cardiomyopathy is closely associated with atrial fibrillation (AF), and some patients exhibit no dysfunction at rest but demonstrate evident changes in left (LA) function LA volume during exercise. This study aimed to identify distinguishing signs exercise stress echocardiography (ESE) among sinus rhythm (SR), without history of paroxysmal/persistent AF (PAF). A prospective cohort 1055 SR was enrolled across 12 centers. The main divided into two groups: the modeling group (n = 513)...
Abstract Background Heart rate reserve (HRR) during exercise evaluates chronotropic incompetence and is a prognostically important marker of cardiac autonomic dysfunction, additive to regional wall motion abnormalities (RWMA) in patients with coronary artery disease. Objectives To assess determinants prognostic value HRR hypertrophic cardiomyopathy (HCM). Methods From 1998 2019, we enrolled 774 HCM (age = 48.8±15.9 years, 410 men) stress echocardiography (ESE) 10 certified centres the...
Stress echo (SE) 2030 study is an international, prospective, multicenter cohort that will include >10,000 patients from ≥20 centers ≥10 countries. It represents the logical and chronological continuation of SE 2020 study, which developed, validated, disseminated “ABCDE protocol” SE, more suitable than conventional to describe complex vulnerabilities contemporary patient within beyond coronary artery disease. SE2030 was started with a recruitment plan 2021 2025 (and follow-up 2030) 12...
Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiovascular disorder worldwide which exhibits considerable heterogeneity. Widespread utilization of next-generation sequencing (NGS) in HCM has uncovered substantial variation and highlighted importance a standardized approach to variant interpretation. According this, accurate consistent interpretation sequence variants essential for effective clinical care individuals their families with HCM. With this regard, 2015 guidelines...
The use of echocardiography, a straightforward and widely available technique, allows for comprehensive assessment the patient with hypertrophic cardiomyopathy (HCM) under both resting stress conditions. true prevalence HCM has been redefined over time by this imaging approach, which also made it feasible to pinpoint parameters that clinicians may stratify patients at risk adverse cardiovascular events. current emerging prognostic predictors in HCM, assessed transthoracic echocardiography...
Abstract Background Reduced coronary flow velocity reserve (CFVR) in the left anterior descending artery (LAD) during vasodilator stress echocardiography (VSE) is a marker of poor outcome and associated with higher baseline (CFV) hypertrophic cardiomyopathy (HCM). However, whether resting CFV has additive predictive value to CFVR VSE HCM unknown. Aim To assess prognostic HCM. Methods 325 adult patients (age=52+15 years, 147 [45%] females) preserved ventricular function no known disease who...
Abstract Background Coronary flow velocity reserve (CFVR) can be assessed with transthoracic echocardiography (TTE) as the stress/rest ratio of coronary (CFV). Reduced CFVR during vasodilator stress (adenosine or dipyridamole) is a powerful predictor adverse outcomes in hypertrophic cardiomyopathy (HCM). However, feasibility and correlates more physiological - recommended exercise (ESE) unresolved. Aim To assess functional HCM. Methods We studied 56 HCM patients (age=49±13 years, 33 [59%]...
In 2022, the Hungarian Cardiovascular Imaging community contributed to several scientifi c papers that were published in international journals. Clinical research activities employed novel echocardiographic methods including two- and three-dimensional, strain tissue Doppler imaging of all cardiac chambers. These modalities applied diff erent patient populations such as patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or post-SARS-CoV-2 aff ected individuals,...